叶敏 - 北京大学

个人简介

1993/09-1997/07，北京中医药大学，中药学院，学士。 1997/09-2000/07，北京中医药大学，中药学院，硕士。 2000/09-2003/07，北京大学，药学院天然药物学系，博士。 2003/07-2005/05，北京大学，药学院天然药物学系，博士后。 2005/05-2006/01，美国Louisiana State University，生物学系，博士后。 2006/01-2007/12，美国Yale University，医学院药理学系，博士后。 2007/12-2012/07，北京大学，药学院天然药物学系，副教授。 2012/08至今，北京大学，药学院天然药物学系，教授

研究领域

1. 活性天然产物的生物合成与生物催化 2. 中药药效成分发现与中药分析

近期论文

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1. Jun-Bin He#, Peng Zhao#, Zhi-Min Hu, Shuang Liu, Yi Kuang, Meng Zhang, Bin Li, Cai-Hong Yun*, Xue Qiao*, Min Ye*. Molecular characterization and structural basis of a promiscuous C -glycosyltransferase from Trollius chinensis . Angew. Chem. Int. Ed. 2019, 58, 11513-11520. 2. Kuan Chen, Zhimin Hu, Wei Song, Zi-long Wang, Jun-bin He, Xiao-meng Shi, Qing-hua Cui, Xue Qiao*, Min Ye*. Diversity of O -glycosyltransferases contributes to the biosynthesis of flavonoid and triterpenoid glycosides in Glycyrrhiza uralensis . ACS Synth. Biol. 2019, DOI: 10.1021/acssynbio.9b00171. 3. Zilong Wang#, Shuang Wang#, Zheng Xu#, Mingwei Li, Kuan Chen, Yaqun Zhang, Zhimin Hu, Meng Zhang, Zhiyong Zhang*, Xue Qiao*, Min Ye*.Highly promiscuous flavonoid 3？ O ？glycosyltransferase from Scutellaria baicalensis . Org. Lett. 2019, 21, 2241？2245. 4. Xue Qiao#, Qi Wang#, Shuang Wang, Yi Kuang, Kai Li, Wei Song, Min Ye*. A 42-markers pharmacokinetic study reveals interactions of berberine and glycyrrhizic acid in the anti-diabetic Chinese medicine formula Gegen-Qinlian Decoction. Front. Pharmacol. 2018, 9, 622. 5. Junbin He#, Kuan Chen#, Zhi-min Hu, Kai Li, Wei Song, Li-yan Yu, Chung-Hang Leung, Dik-Lung Ma, Xue Qiao*, Min Ye*. UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis , catalyzes the regiospecific glycosylation of pentacyclic triterpenoids. Chem. Commun. 2018, 54(62), 8594-8597. 6. Wei Song#, Xue Qiao#, Kuan Chen, Ying Wang, Shuai Ji, Jin Feng, Kai Li, Yan Lin, Min Ye*. Biosynthesis-based quantitative analysis of 151 secondary metabolites of licorice to differentiate medicinal Glycyrrhiza species and their hybrids. Anal. Chem. 2017, 89(5), 3146-3153. 7. Kai Li, Jin Feng, Yi Kuang, Wei Song, Meng Zhang, Shuai Ji, Xue Qiao, Min Ye*. Enzymatic synthesis of bufadienolide O -glycosides as potent antitumor agents using a microbial glycosyltransferase. Adv. Synth. Catal. 2017, 359(21), 3765-3772. 8. Xue Qiao, Xiong-hao Lin, Shuai Ji, Zheng-xiang Zhang, Tao Bo, De-an Guo, Min Ye*. Global profiling and novel structure discovery using multiple neutral loss/precursor ion scanning combined with substructure recognition and statistical analysis (MNPSS): Characterization of terpene-conjugated curcuminoids in Curcuma longa as a case study. Anal. Chem. 2016, 88(1), 703-710. 9. Shuai Ji, Ziwei Li, Wei Song, Yongrui Wang, Wenfei Liang, Kai Li, Shunan Tang, Qi Wang, Xue Qiao, Demin Zhou, Siwang Yu*, Min Ye*. Bioactive constituents of Glycyrrhiza uralensis (licorice): Discovery of the effective components of a traditional herbal medicine. J. Nat. Prod . 2016, 79(2), 281-292. 10. Xue Qiao#, Qi Wang#, Wei Song, Yi Qian, Yao Xiao, Rong An, De-an Guo, Min Ye*. A chemical profiling solution for Chinese medicine formulas using comprehensive and loop-based multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J. Chromatogr. A 2016, 1438, 198-204.