个人简介

长期致力于中药ADMET/Act.的研究。国家十二五科技支撑计划“基于生物、化学、信息等多学科技术集成的中药现代化发展关键技术研究2012BAI29B02”项目首席科学家。主要社会兼职：国家药典委员会委员，世界中医药学会联合会中药化学专业委员会副会长，世界中医药学会联合会中药分析专业委员会常务理事，中华中医药学会理事等；J. Asian Nat. Prod. Res.、《中国中药杂志》、《药物分析杂志》等16 刊杂志编委。

研究领域

主要研究领域包括天然药物化学、天然药物化学成分及其生物转化与创新药物发现、中药复杂体系科学问题研究和药物的ADMET/Act.研究平台建设。

主要研究领域包括天然药物化学、天然药物化学成分及其生物转化与创新药物发现、中药复杂体系科学问题研究和药物的ADMET/Act.研究平台建设。

近期论文

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1.Ma Li-Yuan, Zhang You-Bo, Zhou Qi-Le, Yang Yan-Fang, Yang Xiu-Wei*. Simultaneousdetermination of eight ginsenosides in rat plasma by liquidchromatography–electrospray ionization tandem mass spectrometry: Application totheir pharmacokinetics. Molecules, 2015, 20(12):21597–21608. 2014-IF2.416 2.Ma Li-Yuan, Zhou Qi-Le, Yang Xiu-Wei*. New SIRT1 activator from alkalinehydrolysate of total saponins in the stems-leaves of Panax ginseng. Bioorganic& Medicinal Chemistry Letters, 2015, 25(22):5321–5325. 2014-IF2.42 3.Wu Shuai, Xu Wei, Wang Fu-Rong, Yang Xiu-Wei*. Study of the biotransformation ofTongmai Formula by human intestinal flora and its intestinal permeability acrossthe Caco-2 cell monolayer. Molecules, 2015, 20(10):18704-18716. 2014-IF2.416 4.Ma Li-Yuan, Yang Xiu-Wei*. Six new dammarane-type triterpenes from acidichydrolysate of the stems-leaves of Panax ginseng and their inhibitory–activitiesagainst three human cancer cell lines. Phytochemistry Letters, 2015,13:406-412. 2014-IF 1.45 5.Wei Wei, Rena Kasimu, Yang Xiu-Wei*. New salicin derivatives from the leaves ofPopulus euphratica. Journal of Asian Natural Products Research, 2015,17(5):491-496. 2014-IF 0.913 6.Zhou Qi-Le, Yang Xiu-Wei*. Four new ginsenosides from red ginseng withinhibitory activity on melanogenesis in melanoma cells. Bioorganic &Medicinal Chemistry Letters, 2015, 25:3112–3116. 2014-IF2.42 7.Yang Yan-Fang, Xu Wei, Song Wei, Ye Min, Yang Xiu-Wei*. Transport of twelvecoumarins from Angelicae Pubescentis Radix across a MDCK-pHaMDR cellmonolayer—An in vitro model for blood-brain barrier permeability. Molecules,2015, 20(7):11719-11732 2014-IF 2.416 8.Li Fei, Yang Xiu-Wei*, Krausz Kristopher, Nichols Robert, Xu Wei, PattersonAndrew, Gonzalez Frank J.*. Modulation of colon cancer by nutmeg. Journal ofProteome Research (J. Proteome Res.), 2015, 14 (4):1937-1946. 2014-IF4.245 9.Deng Gai-Gai, Wei Wei, Yang Xiu-Wei*, ZhangYou-Bo, Xu Wei, Gong Ning-Bo, LüYang, Wang Feng-Feng. New coumarins from the roots of Angelica dahurica var.formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activatedRAW264.7 cells. Fitoterapia, 2015, 101:194-200. 2014-IF2.345 10.Cao Gui-Yun, Xu Wei, Yang Xiu-Wei*, Gonzalez FJ, Li Fei. New neolignans from theseeds of Myristica fragrans that inhibit nitric oxide production. FoodChemistry, 2015, 173:231–237. 2014-IF 3.391