梁建辉 - 北京大学

个人简介

梁建辉(出生: 1962-10-04): 医学博士/药学博士后，精神科医师，北京大学药学院分子与细胞药理学系研究员，博士生导师。1978年9月至1983年7月在南华大学医学院医疗系医疗专业学习，获医学学士。1995年7月毕业于北京大学精神卫生研究所，获医学博士。1995年9月至1998年2月在军事医学科学院毒物药物研究所（药学博士后）从事新型抗抑郁剂研究工作。曾任日本国立富山医科药科大学客座研究员和澳大利亚Melbourne大学Howard Florey 研究所访问学者（Visiting Scientist）。目前主要学术任职：亚太地区酒精与成瘾研究学会（Asian Pacific Society for Alcohol and Addiction Research, APSAAR）发起人（Founder）/理事（Regular member），中国药理学会神经精神药理学专业委员会秘书长，北京药理学会神经精神药理学专业委员会副主任委员,《Metabolic Brain Disease》副主编。主持修订我国《麻醉药品品种目录（2013年版）》和《精神药品品种目录（2013年版）》，获得国家自然科学面上基金、科技部国家重点基础研究发展规划项目（973）、十二五国家科技支撑计划、新药创制重大专项等多项基金支持。主要学术贡献：（1）率先在国内开展“行为敏化（behavioral sensitization）”系列研究工作，包括学术名词的翻译，实验范式的建立，戒毒治疗药物的评价以及神经生物学分子机制的研究。在中文药理学教材中，首次引进了“药物敏化(drug sensitization)”的概念及相关内容；（2）引进和繁殖了我国第一个先天嗜酒大鼠模型(‘酒鬼’大鼠)。以FH大鼠嗜酒行为特点为基础，初步建立了戒酒治疗药物筛选和评价技术平台，对相关化合物和中药有效部位的戒酒药理活性进行评价和筛选；（3）在国际上，首先提出“分子伴侣介导阿片成瘾（Chaperone-mediated opioid addiction）”的理论，认为“作为慢性脑病，阿片类药物成瘾可能与相关蛋白质折叠和组装的易化过程（facilitation）有关”；（4）新的抑郁和焦虑共患动物模型的建立及应用。

研究领域

(1) 药物相关行为可塑性（behavioral plasticity）神经生物学机制. (2) 中药组分及其单体戒酒药理活性的筛选和评价. (3) 抑郁和焦虑共患新动物模型的应用及其机制研究

近期论文

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Qin WJ, Wang YT, Li PM, Wang XX, Li JX, Noori HR, Bernardi RE, Liang JH*, Zhang XL*. Context- and time-dependent neurobiological and behavioral sensitization induced by a single morphine exposure in mice. Psychopharmacology (Berl). 2016 Apr; 233(7):1147-55.doi: 10.1007/s00213- 015-4197-2. Wen RT, Feng WY, Liang JH*, Zhang HT*. Role of phosphodiesterase 4-mediated cyclic AMP signaling in pharmacotherapy for substance dependence. Curr Pharm Des. 2015;21(3):355-64. Gao JL, Tu SA, Liu J, Zhang JM, Huang Y, Han M, Liang JH*. An-jun-ning, a traditional herbal formula, attenuates spontaneous withdrawal symptoms via modulation of the dopamine system in morphine-dependent rats.BMC Complement Altern Med. 2014 Aug 19;14:308. doi: 10.1186/1472-6882-14-308. Yu-ling LI, Qing LIU, Qi GONG, Jun-xu LI, Shou-peng WEI, Yan-ting WANG, Hui LIANG, Min ZHANG, Li JING, Zheng YONG, Andrew J. LAWRENCEand Jian-hui LIANG*, The glycine receptor antagonist brucine decreases ethanol intake and preference in alcohol-preferring Fawn-Hooded rats. Acta Pharmacol Sin. 2014 Jul;35(7):853-61. doi: 10.1038/aps.2014.28. Epub 2014 Jun 9. Jing L, Zhang M, Li JX, Huang P, Liu Q, Li YL, Liang H, Liang JH*. Comparison of single versus repeated methamphetamine injection induced behavioral sensitization in mice. Neurosci Lett. 2014 Feb 7;560:103-6. doi: 10.1016/j.neulet.2013.12.024. Epub 2013 Dec 19. Yan-Ting Wang, Wang-Jun Qin, Qing Liu, Yu-Ling Li, Hui Liang, Feng Chen, Andrew J. Lawrence and Jian-Hui Liang*. Chaperone heat shock protein 70 in nucleus accumbens core: a novel biological target of behavioural sensitization to morphine in rats. Int J Neuropsychopharmacol. 2014. 17(3): p. 469-84. doi:10.1017/S1461145713001429 . Qin WJ, Wang YT, Zhang M, Wen RT, Liu Q, Li YL, Chen F, Lawrence AJ, Liang JH*. Molecular chaperone heat shock protein 70 participates in the labile phase of the development of behavioural sensitization induced by a single morphine exposure in mice. Int J Neuropsychopharmacol. 2013(16):647-659. Epub 2012 May 30:1-13. doi:10.1017/S1461145712000557 [Epub ahead of print] . Wen RT, Zhang M, Qin WJ, Liu Q, Wang WP, Lawrence AJ, Zhang HT, Liang JH*. The Phosphodiesterase-4 (PDE4) Inhibitor Rolipram Decreases Ethanol Seeking and Consumption in Alcohol-Preferring Fawn-Hooded Rats. Alcohol Clin Exp Res. 2012 Dec;36(12):2157-67. doi: 10.1111/j.1530-0277.2012.01845.x. Epub 2012 Jun 4. Zhang M, Jing L, Liu Q, Wen RT, Li JX, Li YL, Gong Q, Liang JH*. Tramadol induces conditioned place preference in rats: Interactions with morphine and buprenorphine. Neurosci Lett. 2012 Jun 27;520(1):87-91. Epub 2012 May 22. Qing Liu, Min Zhang, Wang-Jun Qin, Yan-Ting Wang, Yu-Ling Li1, Li Jing, Jun-Xu Li, Andrew J. Lawrence, Jian-Hui Liang* Septal Nuclei Critically Mediate the Development of Behavioral Sensitization to a Single Morphine Injection in Rats.Brain Res. 2012 May 15;1454:90-9. Qing Liu, Wang-Jun Qin, Min Zhang, Yan-Ting Wang, Li Jing, Jun-Xu Li,Jian-Hui Liang*. Morphine attenuates frustration-like behavior induced by sucrose reward deprivation in rats.Neural Regen Res. 2011;6(28):2211-2216. Jing L, Luo J, Zhang M, Qin WJ, Li YL, Liu Q, Wang YT, Lawrence AJ,Liang JH*. Effect of the histone deacetylase inhibitors on behavioural sensitization to a single morphine exposure in mice. Neurosci Lett. 2011 Mar 22. 494 (2011) 169–173 [Epub ahead of print] PMID: 21396430. DOI:10.1016/j.neulet.2011.03.005. Qing Liu, Andrew J. Lawrence, Jian-hui Liang*. Traditional Chinese medicine for treatment of alcoholism: from ancient to modern. Am J Chin Med. 2011;39(1):1-13. DOI: 10.1142/S0192415X11008609. Luo J, Jing L, Qin WJ, Zhang M, Lawrence AJ, Chen F, Liang JH*. Transcription and protein synthesis inhibitors reduce the induction of behavioural sensitization to a single morphine exposure and regulate Hsp70 expression in the mouse nucleus accumbens. Int J Neuropsychopharmacol. 2011 Feb;14(1):107-21. Epub 2010 Jun 2. doi:10.1017/S146114571000057X PMID: 20519062 [PubMed - in process]. Sun YP, Liu Q, Luo J, Guo P, Chen F, Lawrence AJ, Liang JH*. Systemic Administration of Arecoline Reduces Ethanol-Induced Sleeping Through Activation of Central Muscarinic Receptor in Mice. Alcohol Clin Exp Res. 2010 (January), 34(1): 150 – 157; Published Online: Oct 23 2009 4:25PM, DOI: 10.1111/j.1530-0277.2009.01076.x Jian-Hui Liang,Feng Chen, Michael S. Cowen, Fiona Y. Carroll, Duncan Crawford, Philip M. Beart, Andrew J. Lawrence*. The GABAB receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats. Neuropharmacology. 2006 Apr; 50(5):632-9. Jian-Hui Liang*,Keng Wang, Hong-Lei Sun, and Rong Han. Potentiating effect of tramadol on methamphetamine-induced behavioral sensitization in mice. Psychopharmacology (Berl). 2006 Mar; 185(1):1-10. Li JX, Han R, Deng YP, Chen SQ, Liang JH* Different effects of valproate on methamphetamine- and cocaine-induced behavioral sensitization in mice. Behav Brain Res. 2005 Jun 3;161(1):125-32. Wen-Li Zhao, Ze-Hui Gong,Jian-Hui Liang*. A new buprenorphine analogy, thenorphine, inhibits morphine-induced behavioral sensitization in mice.Acta Pharmacol Sin. 2004, November; 25 (11): 1413-1418. Li JX, Zhao WL,Liang JH*. Effects of carbamazepine on morphine-induced behavioral sensitization in mice. Brain Res. 2004 Sep 3; 1019(1-2):77-83. Li JX, Zhang Q, Liang JH*. Valproate prevents the induction, but not the expression of morphine sensitization in mice. Behav Brain Res. 2004 Jul 9; 152(2):251-7. Liang JH*,Li JX, Wang XH, Chen B, Lu Y, Zhang P, Han R, Ye XF. L-type calcium channel blockers enhance 5-HTP-induced antinociception in mice. Acta Pharmacol Sin. 2004 May; 25(5):644-50. Zhou JL, Liang JH*, Zheng JW, Li CL. Nerve growth factor protects R2 cells against neurotoxicity induced by methamphetamine. Toxicol Lett. 2004 Apr 21;150(2):221-7. Ye XF, Lu Y, Zhang P, Liang JH*. Calmodulin inhibitor trifluoperazine attenuates the development and expression of morphine-induced conditioned place preference in rats. Eur J Pharmacol. 2004 Feb 23;486(3):265-71. Zhang Q, Li JX, Zheng JW, Liu RK, Liang JH*. L-type Ca (2+) channel blockers inhibit the development but not the expression of sensitization to morphine in mice. Eur J Pharmacol. 2003 Apr 25;467(1-3):145-50. Liang JH*, Wang XH, Liu RK, Sun HL, Ye XF, Zheng JW. Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in mice. Psychopharmacology (Berl). 2003 Mar;166(3):276-83. Sun HL, Zheng JW, Wang K, Liu RK, Liang JH*. Tramadol reduces the 5-HTP-induced head-twitch response in mice via the activation of mu and kappa opioid receptors. Life Sci. 2003 Jan 31;72(11):1221-30.