个人简介
刘合力，北京大学医学部药学院研究员，博士生导师，国家自然基金优秀青年基金获得者（2013），国家海外高层次人才计划“青年项目”获得者（2012），北京大学优秀青年人才“百人计划”入选者（2011）；美国西北大学Feinberg医学院分子药理学与生物化学系，博士后、Research associate (2006~2011）；中国科学院生物物理研究所，生物化学与分子生物学博士(2005）；Elsevier 期刊Current Research in Pharmacology and Drug Discovery和《中国药学》英文版的编委会成员。长期致力于细胞表面受体的信号转导结构机制和靶向药物研究。以第一作者或者通讯作者身份在Cell、Nature Communications、PNAS、EMBO. J、J Autoimmun.、JBC、FEBS letters等期刊发表了多篇研究论文；受邀在Current Opinion in Structural Biology上发表综述1篇；申请蛋白质类候选药物的国家发明专利2项（其中一项已经获得授权；另一项为选择性识别致癌突变KIT ITD的靶向单克隆抗体）；获得了国家海外高层次人才计划、国家自然基金优秀青年基金、3个国家自然基金面上项目和1个北京市自然基金面上项目等资助。
研究领域
细胞表面受体是全球60%药物的作用靶标，且蕴藏着癌症、神经精神类疾病等诸多重大疾病的药物靶标而亟待发现和确证。探讨潜在药物靶标的结构与功能关系，是精准调控它们功能的基础，是药物靶标确证不可或缺的重要步骤。本课题组将结构生物学技术与传统的药理学研究方法相结合，力图形成有自己特色的研究方向，即“细胞表面受体的分子和结构药理学研究”，旨在探讨细胞表面受体跨膜信号转导的结构机制、基于结构机制发现调节受体功能的分子工具（小分子化合物、单抗、蛋白质）、为癌症或自闭症等神经精神类疾病确证新的药物靶标，以此助力于原创性（first-in-class）“精准药物”的发现。
近期论文
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1. Liu H*. Synaptic organizers: synaptic adhesion-like molecules (SALMs). Current Opinion in Structural Biology. 2019 Feb 8; 54:59-67.
2. Liang W#, Zhang J#, Saint-Martin M#, Xu F, Noraz N, Liu J, Honnorat J*, Liu H*. Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition.J Autoimmun. 2019 Jan; 96:168-177 (#equal contribution)
3. Liu J, Zhang J, Xu F, Lin Z, Li Z, Liu H*. Structural characterizations of human periostin dimerization and cysteinylation. FEBS Lett. 2018 Jun; 592(11):1789-1803 (FEBS Letters Highlights 2018)
4. Lin Z, Liu J, Ding H, Xu F, Liu H*. Structural basis of SALM5-induced PTPδ dimerization for synaptic differentiation. Nature Commun. 2018 Jan 18; 9(1):268
5. Bu Q, Li Z, Zhang J, Xu F, Liu J, Liu H*. The crystal structure of full-length Sizzled from Xenopus laevis yields insights into Wnt-antagonistic function of secreted Frizzled-related proteins. J Biol Chem. 2017 Sep 29; 292(39):16055-16069
6. Jiang X*, Fischer D, Chen X, McKenna SD, Liu H, Sriraman V, Yu HN, Goutopoulos A, Arkinstall S, He X. Evidence for follicle-stimulating hormone receptor as a functional trimer. J Biol Chem. 2014 May 16;289(20):14273-82
7. Jiang X*, Liu H, Chen X, Chen PH, Fischer D, Sriraman V, Yu HN, Arkinstall S, He X. Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12491-6
8. Liu H, Leo C, Chen X, Wong BR, Williams LT, Lin H, He X*. The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1. Biochim Biophys Acta. 2012 Jul; 1824(7):938-45
9. Liu H, Focia PJ, He X*. Homophilic adhesion mechanism of neurofascin, a member of the L1 family of neural cell adhesion molecules, Journal of Biological Chemistry, 2011.1.7, 286(1): 797-805
10. Liu H, Juo ZS, Shim AH, Focia PJ, Chen X, Garcia KC, He X*. Structural basis of Semaphorin-Plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1. Cell. 2010 Sep 3; 142(5):749-61 (Commented by F1000)
11. Shim AH#, Liu H#, Chen X, Lin PC, He X*. Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25): 11307-12 (#equal contribution)
12. Liu H, Shim AH, He X*. Structural characterization of the ectodomain of a disintegrin and metalloproteinase-22 (ADAM22), a neural adhesion receptor instead of metalloproteinase: INSIGHTS ON ADAM FUNCTION, Journal of Biological Chemistry, 2009.10.16, 284(42): 29077-29086 (selected as Papers of the Week)
13. Chen X, Liu H, Focia PJ, Shim AH, He X. Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases.Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18267-72
14. Chen X,Liu H, Shim AH, Focia PJ, He X.Chen X, et al. Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions. Nature Struct Mol Biol. 2008 Jan;15(1):50-6.
15. Liu H#, Chen X#, Focia PJ, He X*. Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases, The EMBO Journal, 2007.2.7, 26(3): 891-901 (#equal contribution)
16. 刘合力、黄国龙等，一种提高白介素IL-34热力学稳定性的方法，中国发明专利授权号ZL2016102555350.1
17. 刘合力、丁焕弟等, 一种选择性识别KIT ITD致癌性突变的单克隆抗体及其应用，中国发明专利申请号201810588853.X
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