董甦伟 - 北京大学

个人简介

Awards and Honors 2018 CPA-Servier Young Investigator Award, Chinese Pharmaceutical Association (CPA) 2017 Excellent Youth Experts of Beijing 2016 14th Chinese International Peptide Symposium (CPS2016) Young Peptide Scientist Award 2013 The Recruitment Program of Youth Experts, Peking University 2010 Lichtin Award for Excellence in Research, Boston University Education 2005-2010 Ph.D., Department of Chemistry, Boston University, Boston, MA, USA (Thesis Advisor: Professor John A. Porco, Jr.) 2001-2005 B.S., College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. Fundings and Supports 2019-2021 National Science Fund for Excellent Young Scholars, NSFC 2018-2022 National Key Research and Development Program, MOST 2017-2020 General Program of National Science Fund, NSFC 2016-2018 National Science Fund for Young Scholars, NSFC Professional Career 2020.2-present : Associate Professor (with tenure), School of Pharmaceutical Sciences, Peking University 2013.10-2020.1: Assistant Professor, School of Pharmaceutical Sciences, Peking University 2010-2013 Post-doc Research Scholar, Memorial Sloan-Kettering Cancer Center (Advisor: Professor Samuel J. Danishefsky)

研究领域

(1) Study and develop new methodologies and strategies for the synthesis of glycopeptides and glycoproteins; (2) Study glycan functions through homogeneous glycoproteins obtained via chemical synthesis; (3) Study the self-assembly of glycopeptides by regulating the molecular structure and changing the external environment .

近期论文

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Enhancing luciferase activity and stability through generative modeling of natural enzyme sequences PNAS 120, e2312848120 (2023).Wenjun Xie,Dangliang Liu, Xiaoya Wang, Aoxuan Zhang, Qijia Wei, Ashim Nandi, Suwei Dong, and and Arieh Warshel Facile Preparation of Carbohydrate-Containing Adjuvants Based on Self-Assembling Glycopeptide Conjugates Biao Wang, Sijin Liu, Haoting Li, Weidong Dong, Haiyun Liu, Jun Zhang, Chao Tian, Suwei Dong Discovery of Itaconate-Mediated Lysine Acylation jacs.3c02332 Dongyang Liu, Weidi Xiao, Haoting Li, Yanling Zhang, Shouli Yuan, Chengxi Li, Suwei Dong*, and Chu Wang* An efficient metal-free desulfurization strategy promoted by Togni-II reagent Chem. Commun., 2023,59, 6513-6516 Jun Zhang, Haiyun Liu,Shuang Teng,Zhiwen Laiao, Lingkui Meng, Qian Wan, and Suwei Dong* Fine Tuning the Properties of Stapled Peptides by Stereogenic α-Amino Acid Bridges chemistry-europechem.202203624 Qian Wang, Fengzhang Wang, Rui Li, Pushu Wang, Ruixin Yuan, Dangliang Liu, Yuan Liu, Prof. Yi Luan, Prof. Chu Wang*, Prof. Suwei Dong* N-Glycan Engineering: Constructing the N-GlcNAc Stump ChemBioChem. e202200388 Qifan Wu, Prof. Dr. Suwei Dong*, Prof. Dr. Weimin Xuan* PDTAC: Targeted Photodegradation of GPX4 Triggers Ferroptosis and Potent Antitumor Immunity J. Med. Chem. 2022, 65, 18, 12176–12187 Sijin Liu, Xi Zhao, Sufang Shui, Biao Wang, Yingxian Cui, Suwei Dong, Tairan Yuwen, and Guoquan Liu* Exploiting Complex-Type N-Glycan to Improve the in Vivo Stability of Bioactive Peptides CCS.Chem.022.202202122 Qijia Wei†, Jun Zhang†, Yuankun Dao, Mengliang Ye, Dangliang Liu, Weidong Dong, Ning Yuan, Hongxing Li, Chunli Song, Mo Li, Xiaomeng Shi* and Suwei Dong* Vascular Endothelial Growth Factor Mimetic Peptide and Parathyroid Hormone (1-34) Delivered via a Blue-Light-Curable Hydrogel Synergistically Accelerate Bone Regeneration ACS Appl. Mater. Interfaces 2022, 14, 31, 35319–35332 Guiyan Wang, Ning Yuan, Ningyu Li, Qijia Wei, Yuping Qian, Jun Zhang, Man Qin, Yuguang Wang*, and Suwei Dong* Synthesis of PNGase-resistant N-glycopeptide containing an α-anomeric glycosidic linkage J Carbohydr Chem 40:7-9, 518-534 Yuankun Dao, Weidong Dong, Jun Zhang & Suwei Dong* O-GlcNAcylation modulates liquid–liquid phase separation of SynGAP/PSD-95 Nat. Chem. (2022) Pinou Lv, Yifei Du, Changdong He, Luxin Peng, Xinyue Zhou, Yi Wan, Menglong Zeng, Wen Zhou, Peng Zou, Chenjian Li, Mingjie Zhang, Suwei Dong and Xing Chen* Site-Specific Protein Modification with Reducing Carbohydrates Angew. Chem. Int. Ed.2022, e202116545 Qifan Wu,Weidong Dong,Hui Miao,Qian Wang,Suwei Dong,Weimin Xuan* Rational Design of Self-Assembled Mitochondria-Targeting Lytic Peptide Conjugates with Enhanced Tumor Selectivity Chem. Eur. J. 2022, 28, e202103517. Sijin Liu, Biao Wang, Yina Sheng, Dr. Suwei Dong* ,Dr. Guoquan Liu* A novel amphiphilic motif at the C-terminus of FtsZ1 facilitates chloroplast division The Plant Cell 2022: 34: 419–432 Xiaomin Liu, Jinjie An, Lulu Wang, Qingqing Sun, Chuanjing An, Bibo Wu, Conghao Hong, Xiaoya Wang, Suwei Dong, Junhua Guo, Yue Feng, Hongbo Gao* O-Glycosylation Induces Amyloid-β To Form New Fibril Polymorphs Vulnerable for Degradation J. Am. Chem. Soc. 2021, 143, 48, 20216–20223 Dangliang Liu, Qijia Wei, Wencheng Xia, Changdong He, Qikai Zhang, Lu Huang, Xiaoya Wang, Yunpeng Sun, Yeyang Ma, Xiaohui Zhang, Yuan Wang, Xiaomeng Shi, Cong Liu*, and Suwei Dong* Functional Characterization and Crystal Structure of the Bifunctional Thioesterase Catalyzing Epimerization and Cyclization in Skyllamycin Biosynthesis ACS Catal. 2021, 11, 18, 11733–11741 Jiahui Yu, Juan Song, Changbiao Chi, Tan Liu, Tongtong Geng, Zonghui Cai, Weidong Dong, Cheng Shi, Xueyang Ma, Zhongyi Zhang, Xiaojie Ma, Baiying Xing, Hongwei Jin, Liangren Zhang, Suwei Dong, Donghui Yang, and Ming Ma* Facile Generation of Strained Peptidyl Thiolactones from Hydrazides and Its Application in Assembling MUC-1 VNTR Oligomers Chin. J. Chem., 39: 2509-2516 Yuankun Dao,Biao Wang,Weidong Dong,Jun Zhang,Chao Zhong,Zhili Zhang,Suwei Dong* Synthesis and biological evaluation of a lipopeptide-based methamphetamine vaccine Chin. Chem. Lett. Volume 32, Issue 4,2021 Liao Fan,Hanxuan Wang,Yuankun Dao,Kai Yuan,Jiazhen Lu,Jie Shi,Ying Han,Suwei Dong,Lin Lu Probing N-Glycan Functions in Human Interleukin-17A Based on Chemically Synthesized Homogeneous Glycoforms J. Am. Chem. Soc. 2021, 143, 7, 2846–2856 Hongxing Li, Jun Zhang, Chuanjing An, and Suwei Dong* Glycopeptide Self-Assembly Modulated by Glycan Stereochemistry through Glycan−Aromatic Interactions J. Am. Chem. Soc. 2020, 142, 40, 17015–17023 Changdong He, Shuang Wu, Dangliang Liu, Changbiao Chi, Weilin Zhang, Ming Ma, Luhua Lai, and Suwei Dong* Self‐Assembling Glycopeptide Conjugate as a Versatile Platform for Mimicking Complex Polysaccharides Adv. Sci. 2020, 2001264 Hanxuan Wang, Zhichao Liu, Chuanjing An, Haoting Li, Fanlei Hu, Suwei Dong* Chemical Syntheses and Biological Evaluation of CXCL14 and Its Site-Selectively Modified Methionine Sulfoxide-Containing Derivatives J. Org. Chem. 2020, 85, 1740–1747 Zonghui Cai, Qijia Wei, Xiujuan Li, Yi Luan*, and Suwei Dong* α-Selective Lysine Ligation and Application in Chemical Synthesis of Interferon Gamma Org. Lett. 2019, 21, 3265–3270 Yuankun Dao, Lin Han, Hanxuan Wang, and Suwei Dong* β-Glucan as an immune activator and a carrier in the construction of a synthetic MUC1 vaccine Chem. Commun. 2019, 55, 253. Hanxuan Wang, Bing Yang, Yinglu Wang, Fen Liu, Alberto Ferna ´ndez-Tejada * and Suwei Dong * Cypemycin Decarboxylase CypD Is Not Responsible for Aminovinyl–Cysteine (AviCys) Ring Formation Org. Lett. 2018, 20, 7670. Wei Ding, Ning Yuan, Dhanaraju Mandalapu, Tianlu Mo, Suwei Dong*, and Qi Zhang*