杨晓改 - 北京大学

个人简介

1987.9-1992.7 北京医科大学药学院，获理学学士学位 1992.9-1995.7 北京医科大学药学院，获理学硕士学位 1995.8-1999.7 北京医科大学药学院任助教、讲师 1999.9-2002.7 北京大学药学院，获理学博士学位 2002.8-2010.8 北京大学药学院任讲师、副教授 2004.9-2005.8 荷兰莱顿大学药物研究中心，访问学者 2010.8-今北京大学药学院任化学生物学系教授

研究领域

细胞无机化学及无机药物药理和毒理学，主要研究内源性或外源性的无机物种生物效应的化学以及细胞生物学基础，包括金属离子及其配合物对细胞生命过程的干预调节以及与细胞应答的关系。

近期论文

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Xiao-Gai Yang*, Kui Wang, Focusing on the link between diabetes, Alzheimer's disease and cancer for the discovery of new medicines, Curr Top Med Chem,2016,.16(7):675-676 Yi Li, Jing-Cheng Liu, You Yu, Wei-Xia Bian, Xia Hu, Xiao-Gai Yang*, Role of vanadyl acetylacetonate-inducedelevation of reactive oxygen species in the regulation of lipolysis and glucose metabolism in3T3L1 adipocytes, J Chin Pharm Sci,2015,24 (11): 726-733 Min Feng, Yun-Zhou Fan, Xiao-Jie Ma, Jin-Xia Li, Xiao-Gai Yang*, The gadolinium-based contrast agent Omniscan？ promotes in vitro fibroblast survival through in situ precipitation, Metallomics, 2015, 7:1103-1110 Jing-Cheng Liu, You Yu, Gang Wang, Kui Wang, Xiao-Gai Yang*, Bis(acetylacetonato)-oxovanadium(IV), bis(maltolato)-oxovanadium(IV) and sodium metavanadate induce antilipolytic effects by regulating hormone-sensitive lipase and perilipin via activation of Akt, Metallomics, 2013(5):813-820 Cong-cong Hou, Gang Wang, Xiao-Gai Yang*, Mitochondria as the main source of vanadyl acetylacetonateinduced reactive oxygen species generation in renal epithelial cell lines, J Chin Pharm Sci,2013(22): 63-66 Cong-Cong Hou, Min Feng, Kui Wang*, Xiao-Gai Yang*, Lanthanides inhibit adipogenesis with promotion of cell proliferation in 3T3-L1 preadipocytes, Metallomics, 2013(5):715-722 Jin-Xia Li, Li-Juan Fu, Xiao-Gai Yang*, Kui Wang*, Integrin-mediated signaling contributes to gadolinium-containing particles-promoted cell survival and G1 to S phase cell cycle transition by enhancing focal adhesion formation,J. Biol Inorg Chem, 2012, 17(3): 375-385. Tong-Tong Liu, Yan-Jun Liu, Qin Wang, Xiao-Gai Yang*, Kui Wang, Reactive-oxygen-species-mediated Cdc25Cdegradation results in differential antiproliferative activities of vanadate, tungstate, and molybdate in the PC-3 human prostate cancer cell line, J. Biol Inorg Chem, 2012, 17(2): 311-320. Qin Wang, Tong-Tong Liu, Ying Fu, Kui Wang, Xiao-Gai Yang*，Vanadium compounds discriminate hepatoma and normal hepatic cells by differential regulation of reactive oxygen species，J. Biol Inorg Chem, 2010(15):1087–1097. Jin-Xia Li, Jing-Cheng Liu, Kui Wang, Xiao-Gai Yang*，Gadolinium-containing bioparticles as an active entity to promote cell cycle progression in mouse embryo fibroblast NIH3T3 cells, J. Biol Inorg Chem, 2010(15):547–557. Lan Yuan, Ping Du, Kui Wang, Xiao-Gai Yang*，Uptake of Diterbium Transferrin, a Potential Multi-photon Excited Microscopy Probe, into Human Leukemia K562 Cells via Transferrin Receptor-mediated Process，J. Biol Inorg Chem2009(14):1243-1251. Li-Juan Fu, Jin-Xia Li,Xiao-Gai Yang*, Kui Wang*, Gadolinium Promoted Cell Cycle Progression with Enhanced S-phase Entry via Activation of Both ERK and PI3K Signaling Pathways in NIH 3T3 cells, J Biol Inorg Chem2009,14(2):219-227. Ying Fu, Qin Wang, Xiao-Gai Yang*,Xiao-Da Yang, Kui Wang., Vanadyl bisacetylacetonate induced G1/S cell cycle arrest via high intensity ERK phosphorylation in HepG2 cells,J Biol Inorg Chem2008(13): 1001–1009. Xiao-Gai Yang,Xiao-Da Yang, Lan Yuan, Kui Wang, DC Crans, The permeability and cytotoxicity of insulin-mimetic vanadium compounds, Pharm. Res. 2004, 21(6), 1026-1033. Xiaogai Yang,Kui Wang, Jingfen Lu, DC Crans, Membrane transport of vanadium compounds and the interaction with the erythrocyte membrane, Coord. Chem. Rev 2003, 237, 103-111.