张亮仁 - 北京大学

个人简介

北京大学教授、博士生导师、北京大学药物化学系主任。兼任中国药学会药物化学专业委员会委员，Heterocycles、Drug Discov. Ther.、Molecules、《药学学报》、《中国药物化学杂志》、《中国药学（英文版）》、《中国药学杂志》等期刊的编委或顾问编委。主要从事核苷、核苷酸及寡核苷酸药物的设计合成、构效关系研究，以及以结构为基础的药物设计与合成。先后主持包括国家自然科学基金、教育部博士点基金、新药创制重大专项等在内的多项科研项目。在国内外学术杂志发表研究论文170 余篇，曾获2002 年教育部自然科学奖二等奖(第2 完成人)、 2004 年国家自然科学二等奖(第2 完成人)。

研究领域

1.核苷、核苷酸及寡核苷酸药物的设计与合成 2.以结构为基础的药物设计与合成以及构效关系研究 3.有机小分子对细胞信号传导系统的调控研究

近期论文

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J Xia, EL Tilahun, EH Kebede, TE Reid, LR Zhang*, XS Wang*, Comparative Modeling and Benchmarking Data Sets for Human Histone Deacetylases and Sirtuin Families. J. Chem. Inf. Model., 2015, 55(2), 374-388. (IF：3.738) F Pei, HW Jin, X Zhou, J Xia, LD Sun, ZM Liu, LR Zhang*, Enrichment Assessment of Multiple Virtual Screening Strategies for Toll-Like Receptor 8 Agonists Based on a Maximal Unbiased Benchmarking Data Set. Chem. Biol. Drug. Design, 2015, 86(5), 185-198. (IF：2.485) LX Zeng, MX Guan, HW Jin, ZM Liu* and LR Zhang*, Integrating Pharmacophore into Membrane Molecular Dynamics Simulations to Improve Homology Modeling of G Protein-coupled Receptors with Ligand Selectivity: A2A Adenosine Receptor as an Example. Chem. Biol. Drug. Design, 2015, 86(6), 1438-1450. (IF：2.485) S Zhang, XW Xue, LR Zhang*, LH Zhang and ZM Liu*, Comparative Analysis of Pharmacophore Features and Quantitative Structure–Activity Relationships for CD38 Covalent and Non-covalent Inhibitors. Chem. Biol. Drug. Design, 2015, 86(6), 1411-1424. (IF：2.485) LR Zhang, JB Yue, LH Zhang. Cyclic Adenosine 5 '-Diphosphoribose (cADPR) Mimics Used as Molecular Probes in Cell Signaling. Chem. Records, 2015, 15(2), 511-523. (IF：5.492) JS Tang, BX Xie, XL Bian, Y Xue, NN Wei, JH Zhou, YC Hao, G Li, LR Zhang*, Ke-wei Wang*. Identification and in vitro pharmacological characterization of a novel and selective alpha 7 nicotinic acetylcholine receptor agonist, Br-IQ17B. Acta Pharmacol. Sin., 2015, 36, 800-812. (IF: 2.825) WJ Wei, YY Lu, BX Hao, KH Zhang, Q Wang, A Miller, LR Zhang, Lihe Zhang, JB Yue*, CD38 is required for neural differetiation of mouse embryonic stem cells by modulating reactive oxygen species (ROS). Stem Cells, 2015, 33, 1664-2673. (IF: 6.523) J Xia, LR Zhang*, XS Wang*, Benchmarking Methods and Data Sets for Ligand Enrichment Assessment in Virtual Screening. Methods, 2015, 71, 146-157. (IF: 3.645) LD Sun, HW Jin, XY Zhao, ZM Liu, YF Guan, ZJ Yang, LR Zhang*, LH Zhang. Search for unfolding and conformational variations of thrombin-binding DNA aptamer: synthesis, circular Dichroism and molecular dynamics simulation. ChemMedChem, 2014, 9, 993-1001. (IF: 3.046) J Xia, HW Jin, ZM Liu, LR Zhang*, XS Wang*. A versatile protocol to build GPCR-specific Benchmarking Set (GBS) for Ligand Based Virtual Screening. J. Chem. Inf. Model., 2014, 54, 1433-1450. (IF: 3.738) SJ Wang, WJ Zhu, X Wang, JG Li, KH Zhang, LR Zhang*, YJ Zhao, HC Lee, LH Zhang. Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase. Molecules, 2014, 19, 15754-15767. (IF: 1.988) WL Huang, T Zuo, HW Jin, ZM Liu, ZJ Yang, XH Yu, LR Zhang*, LH Zhang, Design, synthesis and biological evaluation of indolizine derivatives as HIV-1 VIF-ElonginC interaction inhibitors. Mol. Div., 2013, 17, 221-243. (IF: 2.861) LD Sun, F Tian, BS Feng, ZM Liu, LR Zhang *, JF Pei*, Computational Identification of a New Binding Site in Influenza Virus Hemagglutinin for Membrane Fusion Inhibitors. Chem. Biol. Drug Des., 2013, 82, 267-274. (IF: 2.469) WL Huang, T Zuo, HW Jin, ZM Liu, ZJ Yang, XH Yu, LR Zhang*, LH Zhang, Indolizine Derivatives as HIV-1 VIF-ElonginC Interaction Inhibitors. Chem. Biol. Drug Des., 2013, 81, 730-741. (IF: 2.469) YK Duan, HW Jin, H Yu, ZL Wang, LR Zhang*, JX Huo, Computational investigation of interactions between Cdc37 and celastrol. Mol. Simul., 2013, 39, 270-278. (IF: 1.056) Z Liu, RM Graeff, HW Jin, LR Zhang, LH Zhang*, Studies on CD38 Inhibitors and Their Application to cADPR-Mediated Ca2+ Signaling. Messenger, 2013, 2, 1-14. H Yu, HW Jin, LD Sun, LR Zhang, G Sun, ZL Wang*, YC Yu, Toll-like receptor 7 agonists: chemical feature based pharmacophore identification and molecular docking studies. PLoS ONE, 2013, 8, e56514. (IF: 3.73)