个人简介
1980-1985年7月,本科毕业于北京医科大学药学院药物化学专业,获理学学士学位;1989年12月研究生毕业于北京医科大学药学院药物化学专业,获理学博士学位,留校任教;1990年任北京医科大学药学院药物化学系讲师;1993-1994年赴日本德岛大学药学部访学;1994年任北京医科大学药学院药物化学系副教授,硕士生导师;1995-1996年赴美国加利福尼亚大学旧金山分校访学;1997年任北京医科大学药学院药物化学系副主任;2002年任北京大学药学院药物化学系教授,博士生导师;2009年12月任北京大学药学院副院长;2010年6月任北京大学药学院党委书记。
研究领域
蛋白酶抑制剂类抗老年痴呆药物和抗肿瘤药物研究;激酶抑制剂类抗病毒药物和抗肿瘤药物研究;药物设计、药物合成及构效关系研究;拟肽类和肽核酸类组合合成方法学研究。
近期论文
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Gang Fu, Robert J. Doerksen*, Ping Xu*. Assignment of absolute configuration of sulfinyl dilactones: Optical rotations and 1H NMR experiment and DFT calculations. Journal of Molecular Structure . 2011, 987: 166-173.
Yan Niu, Yuehua Wang, Xiaomin Zou, Xiaoming Yang, Chao Ma, Yang Lü, Bo Zhou, Yue Yuan, Guanhua Du and Ping Xu*. Synthesis and preliminary evaluation of peptidomimetic inhibitors of human β-secretase. European Journal of Medicinal Chemistry. 2010, 45(5): 2089-2094.
Yue Yuan, Xiao-Min Zou, Yan Niu, Feng-Rong Xu, Ke Mou, Bo Zhou, Chao Wang, Yong-Jian Li, Guan-Yu Yang and Ping Xu*. Synthesis of acyclic analogs of Syringolin A as potential 20S proteasome inhibitors. Journal of Chinese Pharmaceutical Sciences. 2010, 19(6): 423-435.
Wenjing Chen, Ke Mou, Bo Xu, Xiaomei Ling*, Jingrong Cui, Ping Xu*. Capillary electrophoresis for screening of 20S proteasome inhibitors. Analytical Biochemistry . 2009, 394 (1): 62–67.
Ke Mou, Bo Xu, Chao Ma, Xiaoming Yang, Xiaomin Zou, Yang Lü, Ping Xu*. Novel CADD-based Peptidyl Vinyl Ester Derivatives as Potential Proteasome Inhibitors. Bioorganic & Medicinal Chemistry Letters . 2008, 18(8): 2198-2202.
Yiqiu Fu, Bo Xu, Xiaomin Zou, Chao Ma, Xiaoming Yang, Ke Mou, Gang Fu, Yang Lü, Ping Xu*. Design and Synthesis of A Novel Class of Furan-based Molecules as Potential 20S Proteasome Inhibitors. Bioorganic & Medicinal Chemistry Letters . 2007, 17(4): 1102-1106.
Xiaoming Yang, Xiaomin Zou, Yiqiu Fu, Ke Mou, Gang Fu, Chao Ma and Ping Xu*. Synthesis of β-Secretase Inhibitors Containing a Hydroxyethylene Dipeptide Isostere. Synthetic Communications . 2007, 37(1): 9-24.
Xin Zhang, Xiaomin Zou and Ping Xu*.TEMPLATE SYNTHESIS OF PEPTIDOMIMETICS COMPOSED OF ASPARTIC ACID MOIETY BY UGI FOUR-COMPONENT CONDENSATION REACTION. Synthetic Communications . 2005; 35(14): 1881-1888.
Wen Hao WANG, Xiao Min ZOU, Xin ZHANG, Yi Qiu FU, Ping XU*. Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction. Chinese Chemical Letters . 2005; 16(5): 585-588.
Ping Xu,* Ting Zhang, Wenhao Wang, Xiaomin Zou, Xin Zhang, Yiqiu Fu. Synthesis of PNA Monomers and Dimers by Ugi Reaction. Synthesis (Stuttgart) . 2003;June(8):1171-1176.
Ping Xu*, Wenwei Lin, Xiaomin Zou. Synthesis of a Peptidomimetic HCMV Protease Inhibitor Library. Synthesis (Stuttgart) . 2002;June(8):1017-1026.