研究领域
bio-organic chemistry
amino acids
medicinal chemistry
heterocycles
peptide mimicry
The Lubell laboratory performs research in medicinal chemistry and peptide science, with particular interest in the development of novel effective methods for the synthesis of heterocycles, amino acids, peptides and peptide mimics.
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Luo, J.; Pardin, C.; Lubell, W. D.; Zhu, X. X. “Poly(vinyl alcohol)-graft-poly(ethylene glycol) resins and their use in solid-phase synthesis and supported TEMPO catalysis”, Chem. Commun., 2007, 21, 2136-2138.Lien - Article - Link
Dorr, A.; Lubell, W. D. “Synthesis of a new p-deficient phenylalanine derivative from a common 1,4-diketone intermediate and study of the influence of aromatic density on prolyl amide isomer population”, Biopolymers, 2007, 88(2), 290-299. Lien - Article - Link
Boeglin, D.; Hamdan, F. F.; Melendez, R. E.; Cluzeau, J.; Laperriere, A.; Heroux, M.; Bouvier, M.; Lubell, W. D. “Calcitonin gene-related peptide analogues with aza and indolizidinone amino acid residues reveal conformational requirements for antagonist activity at the human calcitonin gene-related peptide 1 receptor”, J. Med. Chem., 2007, 50(6), 1401-1408. Lien - Article - Link
Rao, Mallem H. V. R.; Pinyol, E.; Lubell, W. D. “Rigid dipeptide mimics: synthesis of enantiopure C6-functionalized pyrrolizidinone amino acids”, J. Org. Chem., 2007, 72(3), 736-743. Lien - Article - Link
Jolicoeur, B.; Lubell, W. D. “4-Alkoxy- and 4-amino-2,2'-bipyrrole synthesis”, Org. Lett., 2006, 8(26), 6107-6110. Lien - Article - Link
Jolicoeur, B.; Chapman, E. E.; Thompson, A.; Lubell, W. D. “Pyrrole protection”, Tetrahedron, 2006, 62(50), 11531-11563. Lien - Article - Link
Iden, H. S.; Lubell, W. D. “1,4-Diazepinone and Pyrrolodiazepinone Syntheses via Homoallylic Ketones from Cascade Addition of Vinyl Grignard Reagent to a-Aminoacyl-b-amino Esters”, Org. Lett., 2006, 8(16), 3425-3428. Lien - Article - Link
Surprenant, S.; Lubell, William D. “From Macrocycle Dipeptide Lactams To Azabicyclo[X.Y.0]alkanone Amino Acids: A Transannular Cyclization Route for Peptide Mimic Synthesis”, Org. Lett., 2006, 8(13), 2851-2854. Lien - Article - Link
Surprenant, S.; Lubell, W. D. "9-(4-Bromophenyl)-9-fluorenyl as a Safety-Catch Nitrogen Protecting Group" J. Org. Chem. 2006, 71(2), 848-851.Lien - Article - Link
Brouillette, Y.; Rombouts, F. J. R.; Lubell, W. D. "Solid-Phase Synthesis of 3-Aminopyrrole-2,5-dicarboxylate Analogs" J. Comb. Chem. 2006, 8(1), 117-126. Lien - Article - Link
Lubell, W.D., Blankenship, J.W., Fridkin, G., Kaul, R. (2005) Peptides. Science of Synthesis 21.11, Chemistry of Amides. Thieme, Stuttgart, 713-809.
Hansford, K. A.; Guarin, S. A. P., Skene, W. G.; Lubell, W. D. "Bis(pyrrol-2-yl)arylenes from the Tandem Bi-directional Addition of Vinyl Grignard Reagents to Aryldiesters" J. Org. Chem. 2005, 70, 7996-8000. Lien - Article - Link
Boeglin, D.; Lubell, W. D. "Aza-Amino Acid Scanning of Secondary Structure Suited for Solid-Phase Peptide Synthesis with Fmoc Chemistry and Aza-Amino Acids with Heteroatomic Side-Chains" J. Comb. Chem. 2005, 7(6), 864-878. Lien - Article - Link
Fridkin, G.; Lubell, W. D. "Deazapurine solid-phase synthesis: combinatorial synthesis of a library of N3, N5, C6 trisubstituted pyrrolo[3,2-d]pyrimidine d erivatives on cross-linked polystyrene bearing a cysteamine linker" J. Comb. Chem. 2005, 7(6), 977-986. Lien - Article - Link
Rombouts, F. J. R.; Fridkin, G.; Lubell, W. D. "Deazapurine solid-phase synthesis: construction of 3-substituted pyrrolo[3,2-d]pyrimidine-6-carboxylates on cross-linked polystyrene bearing a cysteamine linker" J. Comb. Chem. 2005, 7(4), 589-598. Lien - Article - Link
Kaul, R.; Surprenant, S. Lubell, W. D. "Systematic Study of the Synthesis of Macrocyclic Dipeptide β-Turn Mimics Possessing 8-, 9- and 10- Membered Rings by Ring Closing Metathesis" J. Org. Chem. 2005, 70, 3838-3844 and addition/correction 2005, 70(12), 4901-4902. Lien - Article - Link and/et Lien - Correction - Link
Galaud, F.; Lubell, W. D. "Homoserine-Derived Cyclic Sulfamidate as Chiral Educt for The Diversity Oriented Synthesis of Lactam-Bridged Dipeptides" Biopolymers (Peptide Science) 2005, 80, 665-674. Lien - Article - Link
Sajjadi, Z.; Lubell, W. D. "Amino Acid-Azetidine Chimeras: Synthesis of Enantiopure 3-Substituted Azetidine-2-carboxylic Acids" J. Peptide Res. 2005, 65(2), 298-310. Lien - Article - Link
Dettwiler, J. E.; Lubell, W. D. "Synthesis and Application of L-N-Boc-N-methyl-β-hydroxyvaline in the Preparation of a Depsipeptide" Can. J. Chem. 2005, 83, 793-800. Lien - Article - Link
Bélec, L.; Blankenship, J.W.; Lubell, W.D. "Examination of Structural Characteristics of the Potent Oxytocin Antagonists [dPen1,Pen6]-OT and [dPen1,Pen6,5-tBuPro7]-OT by NMR, Raman, CD Spectroscopy and Molecular Modeling." J. Peptide Sci. 2005, 11, 365-378. Lien - Article - Link