研究领域

biophysical chemistry spectroscopy self-assembled structures lipids

Professor Lafleur’s research is aimed at characterizing the organization of biomolecular self-assembly, defining the physical and chemical laws involved, identifying relationships between structure and function of these biological materials and exploiting their properties for various biotechnology applications.

近期论文

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N. Cottenye, G. Carbajala, Z.-K. Cui, P. Dauphin Ducharme, J. Mauzeroll, M. Lafleur, “Formation, stability, and pH sensitivity of stable, free-floating, giant unilamellar vesicles using palmitic acid - cholesterol mixtures”, Soft Matter, accepted june 2014. Z.-K. Cui, K. Edwards, A. Nieto Orellana, G. Bastiat, J.-P. Benoit, M. Lafleur, "Impact of interfacial cholesterol-anchored polyethylene glycol on sterol-rich non-phospholipid liposomes", J Colloids Interface Sci., 428, 111-120, 2014. Z.-K. Cui, M. Lafleur, "Lamellar self-assemblies of monoalkylated amphiphiles and sterols and their derived liposomes: distinct compositions and distinct properties", Colloids Surf. B, 114, 177-185, 2014. M. Leroy, M. Lafleur, M. Auger, G. Laroche, R. Pouliot, "Characterization of the structure of human skin substitutes by infrared microspectroscopy", Anal. Bioanal. Chem., 405, 8709-8718, 2013. N. Cottenye, Z.-K. Cui, K.J. Wilkinson, J. Barbeau, M. Lafleur, "Interactions between non phospholipid liposomes containing cetylpyridinium chloride and Streptococcus mutans biofilms: modulation of the adhesion and of the biodistribution", Biofouling 29, 817-827, 2013. G. Carbajal, Z.-C. Cui, M. Lafleur, "Non-phospholipid liposomes with high sterol content display a very limited permeability", Science – China, Chemistry, 56, 40-47, 2013 (invited paper). A. Therrien, P. Manjunath, M. Lafleur, "Chemical and Physical Requirements for Lipid Extraction by Bovine Binder of Sperm BSP1", Biochim. Biophys. Acta, 1828, 543-551, 2013. Z.-K. Cui, A. Bouisse, N. Cottenye, M. Lafleur, "Formation of pH-sensitive cationic liposomes with monoalkylated primary amine and cholesterol", Langmuir, 28, 13668-13674, 2012. S. Kwak, E. Brief, D. Langlais, N. Kitson, M. Lafleur, J. Thewalt, "Ethanol perturbs lipid organiation in model stratum corneum membranes: an investigation combining differential scanning calorimetry, infrared and 2H NMR spectroscopy", Biochim. Biophys. Acta 1818, 1410-1419, 2012. M.-F. Lusignan, A. Bergeron, M. Lafleur, P. Manjunath, "The major proteins of bovine seminal plasma interact with caseins and whey proteins of milk extender", Biol. Reprod. 85, 457-464, 2011. M.-A. Gagnon, M. Lafleur, "Comparison between nuclear magnetic resonance profiling and the source/sink approach for characterizing drug diffusion in hydrogel matrices", Pharm. Dev. Techn., 16, 651-656, 2011. M.-A. Gagnon, M. Lafleur, "Comparison of the Structure and the Transport Properties of Low-Set and High-Set Curdlan Hydrogels", J. Colloids Interface Sci. 357, 419-429, 2011. M.-F. Lusignan, M. Puttaswamy, M. Lafleur, "Thermodynamics of the interaction between bovine binder of sperm BSP1 and low-density lipoproteins from hen's egg yolk", Therm. Acta, 516, 88-90, 2011. M. Lafleur, L. Courtemanche, G. Karlsson, K. Edwards, J.-L. Schwartz, P. Manjunath, "Bovine binder-of-sperm protein BSP1 promotes protrusion and nanotube formation from liposomes", Biochem. Biophys. Res. Comm. 399, 406-411, 2010. T. Phoeung, P. Aubron, G. Rydzek, M. Lafleur, "pH-triggered release from non-phospholipid liposomes modulated by the pKa of fatty acid", Langmuir 26, 12769-12776, 2010. Z.-K. Cui, G. Bastiat, C. Jin, A. Keyvanloo, M. Lafleur, "Formation of Fluid Lamellar Phase and Large Unilamellar Vesicles with Octadecyl Methyl Sulfoxide/Cholesterol Mixtures", Langmuir 26, 12733-12739, 2010. Z.-K. Cui, G. Bastiat, C. Jin, A. Keyvanloo, M. Lafleur, "Influence of the Nature of the Sterol on the Behavior of Palmitic Acid/Sterol Mixtures and Their Derived Liposomes", Biochim. Biophys. Acta 1798, 1144-1152, 2010. S. Kwak, M. Lafleur, " Effect of Dimethyl Sulfoxide on the Phase Behavior of Model Stratum Corneum Lipid Mixtures", Chem. Phys. Lipids 161, 11-21, 2009 M.-A. Gagnon, M. Lafleur, " Self and Mutual Diffusion of Small Molecules in High-Set Curdlan Hydrogels Studied by 31P NMR", J. Phys. Chem. B 113, 9084-9091, 2009. E. Brief, S. Kwak, J.T. Cheng, N. Kitson, J. Thewalt, M. Lafleur, "The phase behaviour of an equimolar mixture of N-palmitoyl D-erythro-sphingosine, cholesterol and palmitic acid, a mixture with optimized hydrophobic matching", Langmuir 25, 7523-7532, 2009.