Handa, Hitesh - The University of Georgia - School of Chemical, Materials, and Biomedical Engineering

个人简介

Ph.D., Material Science and Engineering, Wayne State University, 2008 M.S., Material Science and Engineering, Wayne State University, 2007 B.S., Polymer Science and Chemical Technology, Delhi College of Engineering, India, 2002

研究领域

Translational Research Biomaterials for Medical Device Applications Nitric Oxide Releasing Materials Blood-Material Interactions Hemocompatible Materials Antibacterial Coatings Microfluidics Wound Healing Materials Tissue Engineering Animal Models

近期论文

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Brisbois EJ, Wu J, Bayliss J, Wang S, Xi W, Bartlett RH, Meyerhoff ME, Handa H. Optimized polymeric film-based nitric oxide delivery inhibits bacterial growth in a mouse burn wound model. Acta Biomaterilia 2014; 10(10), 4136-4142. Major TC, Handa H, Bartlett RH. Rabbit Thrombogenicity Model: An effective and affordable in vivo assay for polymer hemocompatibility. Journal of Biomaterials Application 2014; 29(4), 479-501. Major TC, Brisbois EJ, Jones A, Annich GM, Bartlett RH, Handa H. The effect of a polyurethane coating incorporating both a thrombin inhibitor and nitric oxide on hemocompatibility in extracorporeal circulation. Biomaterials 2014; 35, 7271-7285. Suchyta DJ, Handa H, Meyerhoff M. A novel nitric oxide releasing heparin conjugate: Preparation and characterization of an agent with combined antiplatelet/anticoagulant activities. Molecular Pharmaceutics 2014; 11(2), 645-650. Handa H, Major TC, Brisbois EJ, Amoako KA, Meyerhoff ME Bartlett RH. Hemocompatibility comparison of biomedical grade polymers using a rabbit thrombogenicity model for preparing nitric oxide releasing nonthrombogenic surfaces. Journal of Materials Chemistry B 2014; 2, 1059-1067. Major TC, Handa H, Brisbois EJ, Annich GM, Reynolds MM, Meyerhoff ME, Bartlett RH. The mediation of platelet quiescence by NO-releasing polymers via cGMP-induced serine 239 phosphorylation of vasodilator-stimulated phosphoprotein. Biomaterials 2013, 34(33):8086-96. Handa H, Brisbois EJ, Major TC, Refahiyat L, Amoako KA, Brant DO, Annich GM, Meyerhoff ME, Bartlett RH. In vitro and in vivo study of sustained nitric oxide release coating using diazeniumdiolate-doped poly(vinyl chloride) matrix with poly(lactic-co-glycolic acid) additive. Journal of Materials Chemistry B 2013; 1, 3578-3587. Brisbois EJ, Handa H, Major TC, Bartlett RH, Meyerhoff ME. Long-term nitric oxide release and elevated temperature stability with S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As polymer. Biomaterials 2013; 34, 6957-6966. Amoako KA, Montoya PJ, Major TC, Handa H, Brant DO, Meyerhoff ME, Bartlett RH, Cook KE. Fabrication and in vivo thrombogenicity testing of nitric oxide generating artificial lungs. Journal of Biomedical Materials Research Part A, 2013; DOI: 10.1002/JBM34655. Amoako KA, Archangeli C, Handa H, Major TC, Meyerhoff ME, Annich GM, Bartlett RH. Thromboresistance characterization of extruded nitric oxide-releasing silicone catheters. American Society for Artificial Internal Organs 2012; 58(3), 238-246. Major TC, Brant DO, Burney PC, Amoako KA, Annich GM, Meyerhoff MH, Handa H, Bartlett RH. The hemocompatibility of a nitric oxide generating polymer that catalyzes S-nitrosothiol decomposition in an extracorporeal circulation model. Biomaterials 2011; 32 (26), 5957-5969. Major TC, Brant DO, Reynolds MM, Bartlett RH, Meyerhoff MH, Handa H, Annich GM. The attenuation of platelet and monocyte activation in a rabbit model of extracorporeal circulation by a nitric oxide releasing polymer. Biomaterials 2010; 31(10), 2736-2745. Handa H, Gurczynski S, Jackson MP, Mao G. Immobilization and molecular interactions between bacteriophage and lipopolysaccharide bilayers. Langmuir 2010; 26 (14), 12095–12103. Blacklock J, Torsten S, Handa H, You Y-z, Oupicky D, Mao G, Mohwald H. Cross-linked bioreducible layer-by-layer films for increased cell adhesion and transgene expression. Journal of Physical Chemistry B 2010; 114, 5283-5291. Khdair A, Handa H, Mao G, Panyam J. Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance in vitro. European Journal of Pharmaceutics and Biopharmaceutics 2009; 71(2), 214-222. Kakade S, Manickam DS, Handa H, Mao G, Oupický D. Transfection activity of layer-by-layer plasmid DNA/poly(ethylenimine) films deposited on PLGA microparticles. International Journal of Pharmaceutics 2009; 365, 44-52. Salakhutdinov I, VandeVord P, Palyvoda O, Matthew H, Tatagiri G, Handa H, Mao G, Auner GW, Newaz G. Fibronectin adsorption to nanopatterned silicon surfaces. Journal of Nanomaterials 2008; DOI: 10.1155/2008/543170. Handa H, Gurczynski S, Jackson MP, Auner G, Walker J, Mao G. Recognition of salmonella typhimurium by immobilized phage P22 monolayers. Surface Science 2008; 602, 1392-1400. Khdair A, Gerard B, Handa H, Mao G, Shekhar MPV, Panyam J. Surfactant-polymer nanoparticles enhance the effectiveness of anticancer photodynamic therapy. Molecular Pharmaceutics 2008; 5(5), 795-807. Blacklock J, Handa H, Manickam DS, Mao G, Mukhopadhyay A, Oupicky D. Disassembly of layer-by-layer films of plasmid DNA and reducible TAT polypeptide. Biomaterials 2007; 28, 117-124. Chavanpatil MD, Handa H, Mao G, Panyam. J. Incorporation of phospholipids enhances cellular uptake and retention of surfactant-polymer nanoparticles. Journal of Biomedical Nanotechnology 2007; 3, 291-296. Chen D, Handa H, Wan L, Mao G. Surface morphological evolution of ultrathin P4VP films and generation of ordered pattern on graphite. Macromolecular Rapid Communication 2007; 28, 1619-1623. Shahani K, Jonnalagadda S, Handa H, Mao G, Panyam J. Phospholipid nanoparticles: process optimization using fractional factorial design and atomic force microscopy. Journal of Biomedical Nanotechnology 2007; 3(4), 394-400. Chavanpatil MD, Khdair A, Patil Y, Handa H, Mao G, Panyam J. Polymer-surfactant nanoparticles for sustained release of water-soluble drugs. Journal of Pharmaceutical Sciences 2007; 96, 3379-3389. Mao G, Chen D, Handa H, Dong W, Kurth DG, Möhwald H. The deposition and aggregation of aspirin molecules on a phospholipid bilayer pattern. Langmuir 2005; 21, 578-585.