个人简介

1960 Ph.D Ohio State University (with Prof. M.L. Wolfrom) 1961-68 Parke Davis & Co., Ann Arbor Michigan 1969-70 Université de Montréal, Associate professor 1970-79 Université de Montréal, Professor 1979-2003 McConnell Professor of Chemistry 1973-present Invited visiting professorships, Paris, Rochester, MIT, Strasbourg, Lyon, Rome 1990-1995 NSERCC - Chair in Medicinal Chemistry 2003- 2006 Isis Pharmaceuticals Research Chair 2005-present Achaogen Research Chair 2006-present Professor, Departments of Chemistry, Pharmaceutical Sciences, and Pharmacology at the University of California, Irvine 2006-present Director of the Medicinal Chemistry and Pharmacology (MCP) Graduate Program at the University of California, Irvine 2006-present Professor, Departments of Chemistry and Pharmaceutical Sciences, University of California, Irvine 2008-present Isis Pharmaceuticals Research Chair Major Awards: 1974 Merck Sharpe & Dohme Award (Chemical Institute of Canada) 1982 Hudson Award (American Chemical Society) 1987 Urgel-Archambault Award, Quebec Association for the Advancement of Science 1988 CIC Palladium Medal (Chemical Institute of Canada) 1988 Alfred Bader Award in Organic Chemistry (Canadian Society for Chemistry) 1988 Fellow, Royal Society of Canada 1989-1990 Fellow, Killam Foundation 1990 NSERCC - Chair in Medicinal Chemistry 1991 Bell Canada-Forum Award 1992 E. Smissman Medal, University of Kansas 1993 M.L. Wolfrom Award (American Chemical Society) 1996 A.C. Cope Scholar Award (American Chemical Society) 1996 Canada Gold Medal for Science and Engineering 1996 Prix Marie-Victorin, Quebec Science Prize 1996 Science Personality of the Year (La Presse) 1997 Killam Memorial Prize (Natural Sciences) 1997 Compagnon Lavoisier (Quebec Order of Chemists) 1998 Officer of the Order of Canada 2001 Doctorate Honoris Causa, University of Siena, Italy 2001 Bernard Belleau Award in Medicinal Chemistry (CSC) 2001 Doctorate Honoris Causa, University of Moncton, NB, Canada 2002 Queen Elisabeth Golden Jubilee Medal 2003 Isis Pharmaceuticals Research Chair 2006 Doctorate Honoris Causa, University of Urbino, Italy 2008 Isis Pharmaceuticals Research Chair 2008 Elected Foreign Member, National Academy of Sciences, Republic of Armenia

研究领域

organic chemistry natural products medicinal chemistry aminoglycosides

Professor Hanessian’s group conducts research into the total synthesis of natural products of biological importance, the design and synthesis of therapeutic products and the development of new methods of asymmetric synthesis.

近期论文

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D. Archard, S. Grisoni, S. Hanessian, C. Moutonnier, J.F. Peyronel, M. Tabart et A. Truchon, Nouveaux dérivés de perhydroisoindole, leur préparation, Eur. Pat., 92401330.3 (1993). D. Archard, S. Grisoni, S. Hanessian, C. Moutonnier, J.F. Peyronel, M. Tabart et A. Truchon, Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent, Eur. Pat., 92401329.5 (1993). S. Hanessian, Amino-cyclodextrins and related structures, Can. Patent, (filed. July 19, 1993). S. Hanessian, Synthesis of Prototypes for Renin Inhibitors, PCT WO95/29150, International (filed April 12, 1995). S. Hanessian, Amino-cyclodextrin syntheses, U.S Patent filed Jan.16, (1996). S. Hanessian and Micheal Rozema, Isomerization process for obtaining 4(S)-Methoxycyclohexane Intermediate in Trinem Synthesis, PCT WO 97/06174 (1997). S. Hanessian, Stereocontrolled Solution and Solid Phase Glycosidation, U.S Patent, 5,767,256 (1998). S. Hanessian and Rozema, Micheal, Isomerization process, Eur. Pat., 871635 (1998). S. Hanessian, A. Ghanem, G. Tucker, D.-H. Caignard and P. Renard, Nouveaux dérivés d’acide hydroxamique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent, Dépôt Initial France, 99402016.2 (filed August 9, 1999). S. Hanessian, J. Wang, et al. Neuramidase Inhibitors, PCT WO 01/29021 A1, April 26, 2001. S. Hanessian, J. Wang, et al. 1-cyclohexene-1-carboxylic acid and 1-cyclohexene-1-carboxylates as Neuraminidase Inhibitors, PCT WO 01/28981 A1, April 26, 2001. S. Hanessian, M. Bayrakdarian, X. Luo, et al. Inhibitors of Neuraminidases, PCT WO 01/28996 A2, April 26, 2001. S. Hanessian, N. Moitessier, C. Gauchet, J. Hickman, G. Tucker, D.H. Caignard, and P.Renard, Nouveaux dériviés d’acide hydroxamique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent, Dépôt Initial France 0100313, (filed November 1, 2001). S. Hanessian, N. Moitessier, B. Mackay, J. Hickman, G. Tucker, D.-H. Caignard and P. Renard, Nouveaux dérivés d’acide hydroxamique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent, Dépôt Initial France, 0100312, (filed November 1, 2001). S. Hanessian, R. Machaalani, S. Marcotte, “Process to prepare malayamycin derivatives as antifungal”, British Patent WO2004069842 A1 (2004). S. Hanessian, S. Marcotte, G. Huang, P. Crowley, P. Jelf, O. Loiseleur, “Preparation of novel 2,7-dioxo-bicyclo[4.3.0]non-5-yl-urea derivatives as plant fungicides”, British Patent WO2004069842 A1, (2004). S. Hanessian, E. Therrien, M. Bayrakdarian, D. Simard, “Preparation of pyridinones useful as thrombin inhibitors”, Swedish pat. WO2005075424 (2005). S. Hanessian, E. Therrien, W. van Otterlo, “New 5,6-dihydropyridine-2-one compounds useful as inhibitors of thrombin”, Swedish pat. WO 2005058826 (2005). S. Hanessian, S. Adhikari, J. Szychowski, E. Swayze “Substituted Antibacterial 4,6-substituted Aminoglycoside Analogs”, US patents 60/753,306 (2005). S. Hanessian, S. Adhikari, J. Szychowski, E. Swayze “Antibacterial 4,5-substituted Aminoglycoside Analogs Having Multiple Substituents”, US patents 60/742,051 (2005).