研究领域

bioanalytical chemistry mass spectrometry molecular imaging tissue analysis proteomics

Professor Chaurand and his group are developing methodologies for analyzing the molecular content of thin tissue sections by mass spectrometry in a region-specific manner. A systematic analysis makes it possible to reconstruct molecular images (proteins, peptides, lipids, metabolites, etc.) that can be directly correlated to the histologies present within the sections and the health of biopsies.

近期论文

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Imaging Mass Spectrometry of Thin Tissue Sections: A Decade of Collective Efforts. P. CHAURAND. Journal of Proteomics, Vol. 75, 4883-4892 (2012). Activity-Based Probes linked with Laser-Cleavable Reporter Tags for Signal Amplification in Imaging Mass Spectrometry: Analysis of Serine Hydrolase Enzymes in Mammalian Tissue. J. YANG, P. CHAURAND, J.L. NORRIS, N.A. PORTER and R.M. CAPRIOLI. Analytical Chemistry, Vol. 84, 3689-3695 (2012). Sublimation of New Matrix Candidates for High Spatial Resolution Imaging Mass Spectrometry of Lipids: Enhanced Information in Both Positive and Negative Polarities After 1,5-diaminonapthalene Deposition. A. THOMAS, J. LAVEAUX CHARBONNEAU, E. FOURNAISE and P. CHAURAND. Analytical Chemistry, Vol. 84, 2048-2054 (2012). MALDI Imaging Mass Spectrometry: A Promising Technique in Reproductive Research. M. LAGARRIGUE, R. LAVIGNE, B. GUEVEL, E. COM, P. CHAURAND and C. PINEAU. Biology of Reproduction. Vol. 86(3)74, 1-11 (2011). Properties of Ionic Liquids on Au Surfaces: Non-conventional Anion Exchange Reactions with Carbonate. M. RATEL, M. BRANCA, J. BREAULT-TURCOT, S.S. ZHAO, P. CHAURAND, A.R. SHMITZER and J-F. MASSON. Chemical Communications, Vol. 47, 10644-10646 (2011). Mass Spectrometry for the Evaluation of Cardiovascular Diseases Based on Proteomics and Lipidomics. A. THOMAS, S. LENGLET, P. CHAURAND, J. DEGLON, P. MANGIN, F. MACH, S. STEFFENS, J-L. WOLFENDER and C. STAUB. Thrombosis & Haemostasis, Vol. 106, 20-33 (2011). Advances in Proteomics Strategies Towards the Early Detection of Lung Cancer. M. HASSANEIN, S.M.J. RAHMAN, P. CHAURAND and P.P. MASSION. Proceedings of the American Thoracic Society, Vol. 8, 183-188 (2011). Perspective: From Whole-Body Sections Down to Cellular Level, Multiscale Imaging of Phospholipids by MALDI Mass Spectrometry. P. CHAURAND, D.S. CORNETT, P.M. ANGEL and R.M. CAPRIOLI. Molecular & Cellular Proteomics, Vol. 10, O110.004259 (2011). Liquid Chromatography-Tandem and MALDI Imaging Mass Spectrometry Analyses of RCL2/CS100-Fixed Paraffin Embedded Tissues: Proteomics Evaluation of an Alternate Fixative for Biomarker Discovery. A. MANGE, P. CHAURAND, H. PERROCHIA, P. ROGER, R.M. CAPRIOLI and J. SOLASSOL. Journal of Proteome Research, Vol. 8, 5619-5628 (2009). Variations in the Expressed Antimicrobial Peptide Repertoire of Northern Leopard Frog (Rana pipiens) Populations Suggest Intraspecies Differences in Resistance to Pathogens. J.A. TENNESSEN, D.C. WOODDHAMS, P. CHAURAND, L.K. REINERT, D. BILLHEIMER, Y. SHYR, R.M. CAPRIOLI, M.S. BLOUIN and L.A. ROLLINS-SMITH. Developmental & Comparative Immunology, Vol. 33, 1247-1257 (2009). MALDI Imaging Mass Spectrometry of Integral Membrane Proteins from Ocular Lens and Retinal Tissue. A.C. GREY, P. CHAURAND, R.M. CAPRIOLI and K.L. SCHEY. Journal of Proteome Research, Vol. 8, 3278-3283 (2009). Mass Spectrometry-Based Proteomic Profiling of Lung Cancer. S. OCAK, P. CHAURAND and P.P. MASSION. Proceedings of the American Thoracic Society, Vol. 6, 159-170 (2009). High-Throughput Proteomic Analysis of Formalin-fixed Paraffin-Embedded Tissue Microarrays Using MALDI Imaging Mass Spectrometry. M.R. GROSECLOSE, P.P. MASSION, P. CHAURAND and R.M. CAPRIOLI. Proteomics, Vol. 8, 3715-3724 (2008). Imaging Mass Spectrometry of Intact Proteins from Alcohol Preserved Tissue Specimens: Bypassing Formalin Fixation. P. CHAURAND, J.C. LATHAM, K.B. LANE, J.A. MOBLEY, V.V. POLOSUKHIN, P.S. WIRTH, L.B. NANNEY and R.M. CAPRIOLI. Journal of Proteome Research, Vol. 7, 3543-3555 (2008). Enhancement of Protein Sensitivity for MALDI Imaging Mass Spectrometry After Chemical Treatment of Tissue Sections. E.H. SEELEY, S.R. OPPENHEIMER, D. MI, P. CHAURAND and R.M. CAPRIOLI. Journal of the American Society for Mass Spectrometry, Vol. 19, 1069-1077 (2008). Monitoring Mouse Prostate Development by Profiling and Imaging Mass Spectrometry. P. CHAURAND, M.A. RAHMAN, T. HUNT, J.A. MOBLEY, G. GU, J.C. LATHAM, R.M. CAPRIOLI and S. KASPER. Molecular & Cellular Proteomics, Vol. 7, 411-423 (2008). MALDI Imaging Mass Spectrometry: Molecular Snapshots of Biochemical Systems. D.S. CORNETT, M.L. REYZER, P. CHAURAND and R.M. CAPRIOLI. Nature Methods, Vol. 4, 828-833 (2007).