研究领域

organic chemistry stereoselective synthesis continuous flow chemistry green chemistry catalysis cyclopropanation chirality amino acids C–H functionalization enantiomers heterocycles organozinc chemistry peptide synthesis novel soluble supports

Professor Charette’s research aims at developing new catalytic methods for the stereoselective synthesis of bioactive organic compounds, which are more powerful than existing methods and compatible with sustainable chemistry. His research is contributing to the development of new molecules with applications in pharmaceuticals, agrochemistry, biology, and food and materials science.

近期论文

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PONS, A.; BEUCHER, H.; IVASHKIN, P.; LEMONNIER, G.; POISSON, T.; CHARETTE, A. B.; JUBAULT, P.; PANNECOUCKE, X. Rhodium-Catalyzed Cyclopropanation of Fluorinated Olefins: A Straightforward Route to Highly Functionalized Fluorocyclopropanes Org. Lett. 2015, 17, ASAP. BECHARA, W. S.; KHAZHIEVA, I. S.; RODRIGUEZ, E.; CHARETTE, A. B. One-Pot Synthesis of 2,4,5,-Trisubstituted 1,2,4-Triazoles via the Addition of Hydrazides to Activated Secondary Amides Org. Lett. 2015, 17, 1184-1187. SUSTAC ROMAN, D.; POIRET, V.; PELLETIER, G.; CHARETTE, A. B. Directed Arylation of Imidazo[1,5-a]azines Through Ruthenium and Palladium Catalysis Eur. J. Org. Chem. 2015, 2015, 67-71. PELLETIER, G.; CONSTANTINEAU-FORGET, L.; CHARETTE, A. B. Directed Functionalization of 1,2-Dihydropyridines: Stereoselective Synthesis of 2,6-Disubstituted Piperidines Chem. Commun. 2014, 50, 6883-6885. CYR, P.; CHARETTE, A. B. Continuous-Flow Hydroxylation of Aryl Iodides Promoted by Copper Tubing Synlett 2014, 1409-1412. LÉVESQUE, É.; GOUDREAU, S. R.; CHARETTE, A. B. Improved Zinc-Catalyzed Simmons-Smith Reaction: Access to Various 1,2,3-Trisubstituted Cyclopropanes Org. Lett. 2014, 16, 1490-1493. SUSTAC ROMAN, D.; CHARETTE, A. B. C-H Functionalization of Cyclopropanes: A Practical Approach Employing a Picolinamide Auxiliary Org. Lett. 2013, 15, 4394-4397. BEAULIEU, L.-P. B.; SCHNEIDER, J. F.; CHARETTE, A. B. Highly Enantioselective Simmons-Smith Fluorocyclopropanation of Allylic Alcohols via the Halogen Scrambling Strategy of Zinc Carbenoids J. Am. Chem. Soc. 2013, 135, 7819-7822. PELLETIER, G.; CHARETTE, A. B. Triflic Anhydride Mediated Synthesis of Imidazo[1,5-a]azines Org. Lett. 2013, 15, 2290-2293. LADD, C.; SUSTAC ROMAN, D.; CHARETTE, A. B. Palladium-Catalyzed Ring-Opening of Cyclopropyl Benzamides: Synthesis of Benzo[c]azepine-1-ones via C(sp3)-H Functionalization Tetrahedron 2013, 69, 4479-4487. LADD, C.; SUSTAC ROMAN, D.; CHARETTE, A. B. Silver-Promoted, Palladium-Catalyzed Direct Arylation of Cyclopropanes: Facile Access to Spiro 3,3'-Cyclopropyl Oxindoles Org. Lett. 2013, 15, 1350-1353. MOUSSEAU, J. J.; CHARETTE, A. B. Direct Functionalization Processes: A Journey from Palladium to Copper to Iron to Nickel to Metal-Free Coupling Reactions Acc. Chem. Res. 2013, 46, 412-424. LINDSAY, V. N. G.; FISET, D.; GRITSCH, P. J.; AZZI, S; CHARETTE, A. B. Stereoselective Rh2(S-IBAZ)4-Catalyzed Cyclopropanation of Alkenes, Alkynes and Allenes: Asymmetric Synthesis of Diacceptor Cyclopropylphosphonates and Alkylidenecyclo-propanes J. Am. Chem. Soc. 2013, 135, 1463-1470. BEAULIEU, L.-P. B.; ZIMMER, L. E.; GAGNON, A.; CHARETTE, A. B. Highly Enantioselective Synthesis of 1,2,3-Substituted Cyclopropanes by Using α-Iodo- and α-Chloromethylzinc Carbenoids Chem. Eur. J. 2012, 18, 14784-14791. PELLETIER, G.; LIE, S.; MOUSSEAU, J. J.; CHARETTE, A. B. One-Pot Synthesis of 1-Iodoalkynes and Trisubstituted Alkenes from Benzylic and Allylic Bromides Org. Lett. 2012, 14, 5464-5467. BEAULIEU, L.-P. B.; SUSTAC ROMAN, D.; VALLÉE, F.; CHARETTE, A. B. Nickel(0)/NaHMDS Adduct-Mediated Intramolecular Alkylation of Unactivated Arenes Via a Homolytic Aromatic Substitution Mechanism Chem. Commun. 2012, 48, 8249-8251. LEMONNIER, G.; CHARETTE, A. B. Grob Fragmentation of 2-Azabicyclo[2.2.2]oct-7-ene: Tool for the Stereoselective Synthesis of Polysubstituted Piperidines J. Org. Chem. 2012, 77, 5832-5837. FISET, D.; CHARETTE, A. B. Microwave-Assisted Hydrolysis: Efficient Synthesis of α-Substituted Cysteines on Multi-gram Scale RSC Adv. 2012, 2, 5502-5505. LINDSAY, V. N. G.; CHARETTE, A. B. Design and Synthesis of Chiral Heteroleptic Rh(II)-Carboxylate Catalysts. Experimental Investigations of the Halogen Bond Rigidification Effects in Asymmetric Cyclopropanation Reactions ACS Catal. 2012, 2, 1221-1225. BULL, J. A.; MOUSSEAU, J. J.; PELLETIER, G.; CHARETTE, A. B. Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition to N-Activated Pyridines Chem. Rev. 2012, 112, 2642-2713.