个人简介
华中科技大学同济医学院附属协和医院药剂科副主任，西院药剂科主任，美国佛罗里达大学访问学者。
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Wang N, Zhu C, Zhang X, et al. Food–drug interactions involving multiple mechanisms: A case study with effect of Capsaicin on the pharmacokinetics of Irinotecan and its main metabolites in rat[J]. Journal of Functional Foods, 2018, 40:292-298. Qin Y, Wang N, Zhang X, et al. IDO and TDO as a potential therapeutic target in different types of depression[J]. Metabolic Brain Disease, 2018:1-14. Darbalaei S, Zhang X, Wang N, et al. Effects of aprepitant on the pharmacokinetics of imatinib and its main metabolite in rats.[J]. Die Pharmazie, 2018, 73(6):329. 秦琰杰, 汪难喜, 张新林,等. 药物代谢酶和转运体介导的辣椒素-药物相互作用研究进展[J]. 中国药学杂志, 2018, 53(1):1-5. 汪难喜, 张新林, 翟学佳,等. 超滤法测定辣椒素对辛伐他汀血浆蛋白结合率的影响[J]. 中国药学杂志, 2017, 52(22):2018-2022. Development of LC-MS/MS Method for Simultaneous Determination of Irinotecan and Its Main Metabolites in Rat Plasma, and Its Application in Pharmacokinetic Studies[J]. Chromatographia,2017,80(1):77-85. Capsaicin induces metabolism of simvasatin in rat: involvement of upregulating expression of Ugt1a1 [J]. Die Pharmazie.2016,71(5)：269-273. LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model .Journal of Ethnopharmacology 169(2015), 363-369 A simple LC-MS/MS method for quantitative analysis of underivatized neurotransmitters in rats urine: assay development, validation and application in the CUMS rat model. Biomedical Chromatography 2015 A simple LC-MS/MS method for the determination of cortisol, cortisone and tetrahydro-metabolites in human urine: assay development, validation and application in depression patients. Journal of Pharmaceutical and Biomedical Analysis 107(2015), 450-455 Capsaicin pretreatment increased the bioavailability of cyclosporin in rats: Involvement of P-glycoprotein and CYP 3A inhibition. Food Chem Toxicol. 62, pp 323-328, 2013. Comparative Bioavailability and Tolerability of a Single 2-mg Dose of 2 Repaglinide Tablet Formulations in Fasting, Healthy Chinese Male Volunteers: An Open-Label, Randomized-Sequence, 2-Period Crossover Study. Curr Ther Res. 75, pp 48-52, 2013. Comparative Bioavailability and Tolerability of Single and Multiple Doses of 2 Diclofenac Sodium Sustained-Release Tablet Formulations in Fasting, Healthy Chinese Male Volunteers. Curr Ther Res. 75, pp 53-58, 2013. Development and validation of a simple LC method for the determination of phenacetin, coumarin, tolbutamide, chlorzoxazone, testosterone and their metabolites as markers of cytochromes 1A2, 2A6, 2C11, 2E1 and 3A2 in rat microsomal medium. Pharmazie 68: 19–26 (2013) Food - drug interactions: Effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats. Food Chem Toxicol. 2013 Mar; 53:168-73 Pharmacokinetic and pharmacodynamic interactions of ethanol and propofol in rabbits. Chromatographia.2010.72.981-985 Mechanism of St. John's wort extract (STW3-VI) during chronic restraint stress is mediated by the interrelationship of the immune, oxidative defense, and neuroendocrine system. Neuropharmacology. 2010 Mar-Apr;58(4-5):767-73. Food–drug interactions: efect of capsaicin on the pharmacokinetics of galantamine in rats. Xenobiotica, 1366-5928,2012.5
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