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个人简介

童擎一,博士,副教授,博士生导师。2014年6月毕业于四川大学生物治疗国家重点实验室,获医学博士学位。2014年7月到华中科技大学同济医学院药学院做博士后,2018年5月留校任讲师,2019年11月至今任副教授。承担本科生《药理学》,研究生《药学生物技术》、《应用药理学》等课程的理论和实验教学,参与的《药理学》分别获2022年国家级和2021年省级一流本科课程认定。已在Cell Discovery, Nucleic Acids Research,Angewandte Chemie-International Edition, Frontiers in Immunology,Organic Letters和Chinese Chemical Letters等学术期刊上发表SCI论文50余篇,其中一作和通讯(含共同)论文26篇,总引用近1200,H因子22。主持国自然面上和青年等基金项目9项,申请专利多项。作为参与人获2021年度湖北省科学技术奖一等奖1项。任中国药理学会会员、抗炎免疫药理专业青委会委员,湖北省毒理学会、药理学会理事,中国免疫学会会员、中医药免疫分会委员。Current Medical Science、医药导报、中国药师等杂志编委、审稿人。

研究领域

1.新药发现及前期研究:从病理出发,构建肿瘤、器官损伤、炎症等疾病模型,从新颖天然产物及其衍生物中筛选出活性分子,或从头设计并筛选出具有相关活性的小分子、嵌合分子(PROTAC、ADC)等,并系统研究它们的作用和机制 2.活性天然产物的作用靶点研究:采用化学生物学、蛋白组学等技术在分子和细胞水平上研究活性天然产物的作用靶点,并在体外和体内疾病模型上对靶点进行确证

近期论文

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Jie Yin, Ziming Zhao, Jianzheng Huang, Yang Xiao, Mewlude Rehmutulla, Biqiong Zhang, Zijun Zhang, Ming Xiang,Qingyi Tong*, Yonghui Zhang*.Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure.Cell Discovery9, 77 (2023). https://doi.org/10.1038/s41421-023-00578-4(IF=33.5, Q1) Qingyi Tong#, Huijuan You#, Xintao Chen, Kongchao Wang, Weiguang Sun, Yufeng Pei, Xiaodan Zhao, Ming Yuan, Hucheng Zhu, Zengwei Luo*, Yonghui Zhang*, ZYH005, a novel DNA intercalator, overcomes all-trans retinoic acidresistance in acute promyelocytic leukemia. Nucleic Acids Research, 2018,46(7):3284–3297.(IF=14.9, Q1) Hucheng Zhu#, Chunmei Chen#,Qingyi Tong#, Jing Yang, Guangzheng Wei, Yongbo Xue, Jianping Wang, Zengwei Luo, and Yonghui Zhang*, Asperflavipine A, an unprecedented cytochalasan heterotetramer uniquely defined by a highly complicated tetradecacyclic ring system from Aspergillus flavipes QCS12, Angewandte Chemie-International Edition, 2017,56(19):5242–5246.(IF=16.6,Q1) Yu Liang#, Biqiong Zhang#, Dongyan Li#, Xuanni Chen, Qiwei Wang, Benlong Shu, Qin Li,Qingyi Tong*, Chunmei Chen*, Hucheng Zhu*, Yonghui Zhang*, Griseofulvin analogues from the fungus Penicillium griseofulvum and their anti-inflammatory activity, Bioorganic Chemistry 139(1):106736.(IF=5.1, Q1) Nan Qiao#, Zhaohong An#, Zeyu Fu, Xingyu Chen,Qingyi Tong*, Yonghui Zhang*, Hong Ren*. Kinsenoside alleviates oxidative stress-induced blood-brain barrier dysfunction via promoting Nrf2/HO-1 pathway in ischemic stroke. European Journal of Pharmacology, 949 (2023), 175717. (IF 5.0) Ping Hu#, Linzhen Hu#, Yizhan Chen#, Fuqian Wang, Yang Xiao, Zhou Tong, Hua Li, Ming Xiang,Qingyi Tong*, Yonghui Zhang*. Chaetocochin J exhibits anti-hepatocellular carcinoma effect independent of hypoxia. Bioorganic Chemistry, 2023, 139, 106701.(IF=5.1, Q1) Yi Kong#, Jian Jiang#, Yuqiong Huang, Xin Liu, Zilin Jin, Li Li, Fen Wei, Xinxin Liu, Jie Yin, Yonghui Zhang*,Qingyi Tong* and Hongxiang Chen*, Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis. Frontiers in Immunology, 13:1094375.(IF=7.3, Q1) Yi Kong, Jian Jiang, Yuqiong Huang, Li Li, Xin Liu, Zilin Jin, Fen Wei, Xinxin Liu, Song Zhang, Xiaoru Duan, Yonghui Zhang*,Qingyi Tong*, Hongxiang Chen*,Endoplasmic reticulum stress in melanoma pathogenesis and resistance.Biomedicine & Pharmacotherapy.2022,155:113741.(IF=7.5, Q1) Shuang Lin#, Jianzheng Huang#, Hanxiao Zeng,Qingyi Tong*, Xueke Zhang, Beiye Yang, Ying Ye, Jianping Wang, Zhengxi Hu*, Yonghui Zhang*.Distachydrimanes A–F, phenylspirodrimane dimers and hybrids with cytotoxic activity from the coral-derived fungus Stachybotrys chartarum. Chinese Chemical Letters. 2022 (33) 4587–4594(IF=9.1,Q1) Xiaotian Zhang#, Zhaodi Wu#,Alan Bao, Ziming Zhao, Yu Chen, Huimin Zhao, Jianping Wang, Chunmei Chen,Qingyi Tong*, Hucheng Zhu*, Yonghui Zhang*. Asperflavipines C–E and aspermichalasine A: three cytochalasan heterotetramers and an unusual cytochalasan monomer from Aspergillus micronesiensis. Organic Chemistry Frontier, 2022,9, 2585-2592(IF=5.5,Q1) Yulin Duan#, PingHu#, YiGuo, Pengfei Bu, Zhengyi Shi,Yunfang Cao, Yeting Zhang, Hong Hu,Qingyi Tong*, Changxing Qi*, Yonghui Zhang*. Kiiacylphnols A−H, eight undescribed polycyclic polyprenylated acylphloroglucinols with anticancer activities from Hypericum przewalskii Maxim. Phytochemistry. 2022 (199) 113166.(IF=4.0,Q1) Si Yao, Jie Yin, Wen Liu, Yang Li, Jianzheng Huang, Changxing Qi, Zhengxi Hu,Qingyi Tong*, Lianghu Gu*, Yonghui Zhang*. A novel Gboxin analog induces OXPHOS inhibition and mitochondrial dysfunction-mediated apoptosis in diffuse large B-cell lymphoma. Bioorganic Chemistry, 2022, 127, 106019.(IF=5.1, Q1) Beiye Yang#,Jianzheng Huang#,Shuang Lin,Qingyi Tong*, Zeyu Yao, Fengli Li, Ying Ye, Zhengxi Hu *, Yonghui Zhang*, Hyperbeanone A, a 5,6-seco-spirocyclic polycyclic polyprenylated acylphloroglucinol derivative with an unprecedented skeleton from Hypericum beanie. Organic Chemistry Frontiers, 2021,8, 6411-6418(IF=5.5, Q1) Mengsha Wei#, Peng Zhou#, Liping Huang, Jie Yin, Qin Li, Chong Dai, Jianping Wang, Lianghu Gu*,Qingyi Tong*, Hucheng Zhu*,Yonghui Zhang*,Spectanoids A-H: Eight undescribed sesterterpenoids from Aspergillus spectabilis, Phytochemistry, 2021, 191 112910. (IF=4.0,Q1) Jiaxiong Ming, Qianqian Xu, Limin Gao, Yanfang Deng, Jie Yin, Qun Zhou*,Qingyi Tong*, Yonghui Zhang*.Kinsenoside Alleviates 17α-Ethinylestradiol-Induced Cholestatic Liver Injury in Rats by Inhibiting Inflammatory Responses and Regulating FXR-Mediated Bile Acid Homeostasis.Pharmaceuticals, 2021,14(5):452.(IF=5.8,Q1) Song Hu#, Jie Yin#, Shan Yan, Ping Hu, Jianzheng Huang, Geng Zhang, Fuqian Wang*,Qingyi Tong*, Yonghui Zhang*, Chaetocochin J, an epipolythiodioxopiperazine alkaloid, induces apoptosis and autophagy in colorectal cancer via AMPK and PI3K/AKT/mTOR pathways. Bioorganic Chemistry, 2021, 109, 104693.(IF=5.1, Q1) Zhaodi Wu#; Xiaotian Zhang#, Chunmei Chen#, Peng Zhou, Mi Zhang, Lianghu Gu, Zengwei Luo, Jianping Wang,Qingyi Tong*, Hucheng Zhu*, Yonghui Zhang*, Dimericchalasine A and Amichalasines D and E: Unexpected Cytochalasan Homodimer and Heterotrimers from Aspergillus micronesiensis PG-1. Organic Letters, 2020,22(6), 2162-2166.(IF=6.1, Q1) Zhaodi Wu#,Qingyi Tong#, Xiaotian Zhang, Peng Zhou, Chong Dai, Jianping Wang, Chunmei Chen*, Hucheng Zhu*, and Yonghui Zhang*,Amichalasines A–C: Three Cytochalasan Heterotrimers from Aspergillus micronesiensis PG-1. Organic Letters 2019, 21 (4), 1026–1030.(IF=6.1, Q1) Yi Guo#,Qingyi Tong#,Na Zhang, Xueyan Duan, Yunfang Cao, Hucheng Zhu, Shuangshuang Xie, Jing Yang, Jinwen Zhang, Yanfei Liu, Yongbo Xue* and Yonghui Zhang*, Highly-functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols fromHypericum perforatuminduce leukemia cell apoptosis. Organic Chemistry Frontiers, 2019,6, 817-824.(IF=5.5, Q1) Guangzheng Wei#, Chunmei Chen#,Qingyi Tong#, Jinfeng Huang, Wenjing Wang, Zhaodi Wu, Jing Yang, Junjun Liu, Yongbo Xue, Zengwei Luo, Jianping Wang, Hucheng Zhu*, and Yonghui Zhang*,Aspergilasines A–D: four merocytochalasans with new carbon skeletons from Aspergillus flavipes QCS12, Organic Letters, 2017, 19, 4399−4402.(IF=6.1, Q1) Qingyi Tong#, Yong Qing#, Dan Shu, Yang He, Yinglan Zhao, Yi Li, Zhengling Wang, Shiyuan Zhang, Zhihua Xing, Cheng Xu, Yuquan Wei, Wen Huang*, Xiaohua Wu*.Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and anti-angiogenesis.Cellular Physiology and Biochemistry, 2011, 27, 233–242. Qingyi Tong,Yong Qing*, Yang Wu, Xiaojuan Hu, Lei Jiang, Xiaohua Wu*, Dioscin inhibits colon tumor growth and angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways.Toxicology and Applied Pharmacology, 2014, 281, 166–173. Qingyi Tong, QingbingZhao, Yong Qing, Xiaojuan Hu, Lei Jiang, Xiaohua Wu*.Deltonin inhibits angiogenesis by regulating VEGFR2 and subsequent signaling pathways in endothelial cells.Steroids, 2015, 96, 30–36. Qingyi Tong#, YangHe#, Qingbing Zhao, Yong Qing*, Wen Huang*, Xiaohua Wu* Cytotoxicity and apoptosis-inducing effect of steroidal saponins from dioscorea zingiberensis wright against cancer cells. Steroids, 2012,77, 1219–1227. Chunmei Chen#,Qingyi Tong#, Hucheng Zhu, Dongdong Tan, Jinwen Zhang, Yongbo Xue, Guangmin Yao, Zengwei Luo, Wang Jianping*, Wang Yanyan*, Zhang Yonghui*. Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales). Scientific Reports, 2016, 6:18711. Weiguang Sun#, Xintao Chen#,Qingyi Tong#, Hucheng Zhu#, Yan He, Liang Lei, Yongbo Xue,Guangmin Yao, Zengwei Luo, Jianping Wang, Hua Li ,Yonghui Zhang.Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune. Scientific Reports, 2016, 6:26418.

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