卢丽丽 - 华中科技大学

个人简介

2019.11至今，华中科技大学药学院，教授，博士生导师 2016.12至2019.10，华中科技大学药学院，副教授，博士生导师 2013.7~2014.10，美国韦恩州立大学化学系，访问学者 2010.12~2016.11，山东大学国家糖工程技术研究中心，副教授，硕士生导师 2007.10~2009.12，山东大学药学院，药学博士后 2007.7~2010.11，山东大学国家糖工程技术研究中心，讲师 2002.7~2007.6，山东大学微生物技术国家重点实验室，微生物学博士 1998.9~2002.6，湖北师范大学，生物科学学士

研究领域

生物技术制药及糖生物化学：重点以生物酶或构建含糖链加工相关生物酶的细胞工厂，进行食品、药物及疾病相关的糖链合成研究，包括功能性低聚糖、寡糖抗感染药物、肿瘤糖链相关抗原、GPI锚定蛋白等糖缀合物；此外还涉及天然产物及药物分子的糖基化修饰及药理活性研究等。

近期论文

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Lili Lu*, Longcheng Guo, Ke wang, Yan Liu, Min Xiao. β-Galactosidases: A great tool for synthesizing galactose-containing carbohydrates.Biotechnol Adv.2020, 39, 107465. Yali Tuo, Zijun Zhang, Cheng Tian, Qinyu Hu, Rui Xie, Jian Yang, Hong Zhou,Lili Lu*, Ming Xiang*. Anti-inflammatory and metabolic reprogramming effects of MENK produce antitumor response in CT26 tumor-bearing mice.J Leukoc Biol.2020, 108(1):215-228. Ke wang, Tingting Qi, Longcheng Guo, Zhongxuan Ma, Guofeng, Gu, Min Xiao*,Lili Lu*. Enzymatic glucosylation of salidroside from starch by α-amylase.J Agric Food Chem. 2019, 67(7):2012-2019. Longcheng Guo, Zhongxuan Ma,Lili Lu*, Min Xiao*. Progress in catalytic mechanism of sialidases and their functions in oligosaccharide hydrolysis and synthesis.Prog Biochem Biophys.2019,46(2):181~192. Longcheng Guo, Xiaodi Chen, Li Xu, Min Xiao*,Lili Lu*. Enzymatic synthesis of 6'-Sialyllactose, a dominant sialylated human milk oligosaccharide, by a novel exo-α-sialidase fromBacteroides fragilisNCTC9343.Appl Environ Microbiol.2018, 84(13): pii: e00071-18. Tingting Qi, Guofeng Gu, Li Xu, Min Xiao*,Lili Lu*.Efficient synthesis of tyrosol galactosides by the β-galactosidase fromEnterobacter cloacaeB5.Appl Microbiol Biotechnol.2017, 101(12):4995-5003. Xiaodi Chen, Li Xu, Lan Jin, Bin Sun, Guofeng Gu,Lili Lu*, Min Xiao*. Efficient and regioselective synthesis ofβ-GalNAc/GlcNAc-lactose by a bifunctional transglycosylatingβ-N-acetylhexosaminidase fromBifidobacterium bifidum.Appl Environ Microbiol. 2016, 82(18):5642-5652. Wei Gong,Li Xu,Guofeng Gu,Lili Lu*,Min Xiao*. Efficient and regioselective synthesis of globotriose by a novel α-galactosidase fromBacteroides fragilis.Appl Microbiol Biotechnol.2016, 100(15):6693-6702. Lijuan Xu, Tingting Qi, Li Xu,Lili Lu*, Min Xiao*.Recent progress in the enzymatic glycosylation of phenolic compounds.J Carbohyd Chem.2016, 35(1):1-23. Jie Zhang#,Lili Lu#, Li Lu, Yang Zhao, Liping Kang, Xu Pang, Jingyuan Liu, Tengchuan Jiang, Min Xiao*, Baiping Ma*.Galactosylation of steroidal saponins by β-galactosidase from Lactobacillus bulgaricusL3.Glycoconj J.2016, 33(1):53-62. Lili Lu, Yuchuan Guo, Lijuan Xu, Tingting Qi, Lan Jin, Li Xu, Min Xiao. Galactosylation of caffeic acid by an engineered β-galactosidase.Drug Discoveries & Therapeutics. 2015, 9(2):123-128. Lili Lu#, Jian Gao#, Zhongwu Guo*. Labeling cell surface GPIs and GPI-anchored proteins through metabolic engineering with artificial inositol derivatives.Angew Chem Int Ed. 2015, 54(33): 9679-9682. Lili Lu#, Qian Liu#, Lan Jan, Zhenghao Yin, Li Xu, Min Xiao*.Enzymatic synthesis of rhamnose containing chemicals by reverse hydrolysis.PLoS One. 2015, 10(10):e0140531. Lili Lu,Lijuan Xu, Yuchuan Guo, Dayu Zhang, Tingting Qi, Lan Jin, Guofeng Gu, Li Xu, and Min Xiao*. Glycosylation of phenolic compounds by the site-mutated β-galactosidase fromLactobacillus bulgaricusL3.PLoS One.2015, 10(3):e0121445. Lili Zhang#,Lili Lu#Shuquan Fan#, Lan Jin, Guofeng Gu, Li Xu, and Min Xiao*. One-step synthesis of α-Gal epitope and globotriose derivatives by an engineered α-galactosidase,RSC Adv. 2015, 5, 22361-22364. Lili Lu, Feng Fu, Renfei Zhao, Lan Jin, Chunjuan He, Min Xiao*. A recombinant levansucrase fromBacillus licheniformis8-37-0-1 catalyzes versatile transfructosylation reactions.Process Biochem.2014, 49: 1503-1510. Lili Lu, Jian Wu, Deyong Song, Han Zhao, Yuchuan Guo, Guofeng Gu, Nan Jin, Min Xiao*. Purification of fructooligosaccharides by immobilized yeast cells and identification of a novel glycoside formed during the process.Bioresour Technol. 2013, 132: 365-369. Lili Lu, Shuze Xu, Renfei Zhao, Dayu Zhang, Zhengyi Li, Yumei Li, Min Xiao*. Synthesis of galactooligosaccharides by CBD fusion β-galactosidase immobilized on cellulose. Bioresource Technol. 2012, 116:327-333. Lili Lu, Shuze Xu, Lan Jin, Dayu Zhang, Yumei Li, Min Xiao*. Synthesis of galactosyl sucralose by β-galactosidase fromLactobacillus bulgaricusL3.Food Chem. 2012, 134(1): 269-275. Qian Liu#,Lili Lu#, Min Xiao*.Cell surface engineering of α-L-rhamnosidase for naringin hydrolysis. Bioresource Technol. 2012, 123: 144–149.