游慧娟 - 华中科技大学

个人简介

教育经历 2008.10 ~ 2012.11 大阪大学 - Department of Biotechnology, Graduate School of Engineering - 工学博士学位 - 研究生(博士)毕业 2006.10 ~ 2008.9 大阪大学 - Department of Biotechnology, Graduate School of Engineering - 工学硕士学位 - 研究生(硕士)毕业 2001.9 ~ 2006.7 北京大学 - Biological Science - 理学学士学位 - 本科(学士) 工作经历 2011.10-2013.3 东京大学 - 工学院应用化学专业 - Project Academic Support Specialist 2013.6-2016.12 新加坡国立大学 - 力学生物学研究所 - Research Fellow

研究领域

靶向核酸的小分子药物的单分子研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Zhang Y, Cheng Y, Chen J, Zheng K*, You H*.Mechanical diversity and folding intermediates of parallel-stranded G-quadruplexes with a bulge.Nucleic Acids Research.2021.DOI: 10.1093/nar/gkab531.. Cheng Y, Zhang Y, You H*.Characterization of G-Quadruplexes Folding/Unfolding Dynamics and Interactions with Proteins from Single-Molecule Force Spectroscopy.Biomolecules.2021.doi: 10.3390/biom11111579.. Li X, Pei Y, Zhang Y, Liu Y, Fu W, Li J, You H*, Huang J*.Single-Molecule Mechanical Unfolding of AT-Rich Chromosomal Fragile Site DNA Hairpins: Resolving the Thermodynamic and Kinetic Effects of a Single G-T Mismatch.The journal of physical chemistry.B.2020.DOI: 10.1021/acs.jpcb.0c06954.. Cheng, Y., Zhang, Y., Gong, Z., Zhang, X., Li, Y., Shi, X., Yufeng Pei, and You, H*. High Mechanical Stability and Slow Unfolding Rates Are Prevalent in Parallel-Stranded DNA G-Quadruplexes. The Journal of Physical Chemistry Letters, 2020, DOI: 10.1021/acs.jpclett.0c02229.. Cheng, Y., Tang, Q., Li, Y., Zhang, Y., Zhao, C., Yan, J., You, H*. Folding/unfolding kinetics of G-quadruplexes upstream of the P1 promoter of the human BCL-2 oncogene. Journal of Biological Chemistry. 2019 294 (15), 5890-5895.. Pei, Y., Liu, Y., Xie, C., Zhang, X., You.You, H*.Pei, Y., Liu, Y., Xie, C., Zhang, X., You, H*.Detecting the Formation Kinetics of Doxorubicin-DNA Interstrand Cross-link at the Single-Molecule Level and Clinically Relevant Concentrations of Doxorubicin. Analytical Chemistry. 2020, 92 (6), 4504-4511..2020, Tong, Q(#)., You, H(#)., Chen, X., Wang, K., Sun, W., Pei, Y., Zhao, X., Yuan, M., Zhu, H., Luo, Z(*)., Zhang, Y(*). ZYH005, a novel DNA intercalator, overcomes all-trans retinoic acid resistance in acute promyelocytic leukemia. Nucleic Acids Research. 2018, gky202, https://doi.org/10.1093/nar/gky202. You, H(#)., Guo, S(#)., Le, S., Tang, Q., Yao, M., Zhao, X., & Yan, J(*). Two-State Folding Energy Determination Based on Transition Points in Non-Equilibrium Single-Molecule Experiments. The journal of physical chemistry letters. 2018, 9 (4), pp 811–816. Iino, R(#)(*)., Iida, T., Nakamura, A., You, H(*)., Saita, E., Sako, Y (*) . Single-molecule imaging and manipulation of biomolecular machines and systems. Biochimica et Biophysica Acta (BBA) - General Subjects, 2018.2.1, 1862(2): 241~252. You, H(#)(*)., Le, S(#)., Chen, H., Qin, L., & Yan, J(*). Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers. Journal of visualized experiments: JoVE, 2017 (127). You H(#)., Lattmann S(#)., Rhodes, D(*)., Yan J(*). RHAU helicase stabilizes G4 in its nucleotide-free state and destabilizes G4 upon ATP hydrolysis. Nucleic Acids Research, 2017, 45(1): 206-214.. You, H(#)., Wu, J., Shao, F., & Yan, J(*). Stability and kinetics of c-MYC promoter G-quadruplexes studied by single-molecule manipulation. Journal of the American Chemical Society, 2015, 137 (7), 2424-2427.. Watanabe R(#), Koyasu K(#), You H, Tanigawara M, Noji H(*). Torque transmission mechanism via DELSEED loop of F1-ATPase. Biophysical Journal 2015, 108 (5), 1144-1152.. You H(#), Zeng X, Xu Y, Lim C.J, Efremov A, Phan A.T, Yan J(*). Dynamics and stability of polymorphic human telomeric G-quadruplex under tension. Nucleic Acids Research 2014, 42 (13), 8789-8795.. You H(#), Iino R, Watanabe R, Noji H(*). Winding single-molecule double-stranded DNA on a nanometer-sized reel. Nucleic Acids Research 2012 40 (19): e151. doi: 10.1093/nar/gks651.