向明 - 华中科技大学

个人简介

2010 年赴美国佐治亚医学院从事抗炎免疫抑制剂药理作用研究。 2004 年至2005年赴德国海德堡大学从事抗HCV感染基因疫苗及树突状细胞分化及功能研究。 1997 年至 1999 年赴意大利 CATANIA 大学从事自身免疫病发病和细胞因子抗体的作用及机制研究。

研究领域

抗炎免疫药理学，主要包括：研究基于天然免疫与获得性免疫相关联的自身免疫性疾病（T1D，RA，AIH等）及慢性炎症（胰腺炎、糖尿病肾病和胰岛素抵抗）发病机制；研究基于表观遗传和细胞代谢的免疫细胞功能转化机制；研究抗肿瘤免疫治疗的方式及机制；研究化学及中药新型免疫抑制剂的作用及机制。

近期论文

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Tuo Y, Xiang M*. mTOR: A double-edged sword for diabetes. J Leukoc Biol. 2018 Mar 26. doi: 10.1002/JLB.3MR0317-095RR. (*corresponding author) Cao H, Li S, Xie R, Xu N, Qian Y, Chen H, Hu Q, Quan Y, Yu Z, Liu J, Xiang M*. Exploring the Mechanism of Dangguiliuhuang Decoction Against Hepatic Fibrosis by Network Pharmacology and Experimental Validation. Front Pharmacol. 2018 Mar 5;9:187. doi: 10.3389/fphar.2018.00187. Liu X, Zhou Z, Cheng Q, Wang H, Cao H, Xu Q, Tuo Y, Jiang L, Zou Y, Ren H, Xiang M*. Acceleration of pancreatic tumorigenesis under immunosuppressive microenvironment induced by Reg3g overexpression. Cell Death Dis. 2017 Sep 7;8(9):e3033. doi: 10.1038/cddis.2017.424. Cao H, Tuo L, Tuo Y, Xia Z, Fu R, Liu Y, Quan Y, Liu J, Yu Z, Xiang M*. Immune and Metabolic Regulation Mechanism of Dangguiliuhuang Decoction against Insulin Resistance and Hepatic Steatosis. Front Pharmacol. 2017 Jul 7;8:445. doi: 10.3389/fphar.2017.00445. Xiang M, Liu T, Tan W, Ren H, Li H, Liu J, Cao H, Cheng Q, Liu X, Zhu H, Tuo Y, Wang J, Zhang Y. Effects of kinsenoside, a potential immunosuppressive drug for autoimmune hepatitis, on DCs-CD8+T cells communication. Hepatology. 2016 Dec 64(6):2135-2150. doi: 10.1002/hep.28825. Xia F, Cao H, Du J, Liu X, Liu Y, Xiang M*. Reg3g overexpression promotes β cell regeneration and induces immune tolerance in nonobese-diabetic mouse model. J Leukoc Biol. 2016 Jun; 99(6):1131-40. doi: 10.1189/jlb.3A0815-371RRR. Xu QQ, Fu R, Yin GX, Liu XL, Liu Y, Xiang M*. Microarray-based gene expression proﬁling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells. Gene.2016 Mar 10; 578(2):263-73. doi: 10.1016/j.gene.2015.12.039. 许倩倩，周仲实，向明*。慢性胰腺炎恶性转化的相关信号通路研究进展。药学学报. 2016;51(2):174-81. Liu X, Wang J, Wang H, Yin G, Liu Y, Lei X, Xiang M*. REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A-JAK2/STAT3 positive feedback loop. Cancer Lett. 2015 Jun 28; 362(1): 45-60. doi: 10.1016/j.canlet.2015.03.014. Cao H, Lu J, Du J, Xia F, Wei S, Liu X, Liu T, Liu Y, Xiang M*. TAK1 inhibition prevents the development of autoimmune diabetes in NOD mice. Sci Rep. 2015 Oct 13;5:14593. doi: 10.1038/srep14593. Wang J, Cao H, Wang H, Yin G, Du J, Xia F, Lu J, Xiang M*. Multiple mechanisms involved in diabetes protection by lipopolysaccharide in non-obese diabetic mice. Toxicol Appl Pharmacol. 2015 Jun 15;285 (3):149-58. doi:1016/j.taap. 2015. 04. 006. Liu T, Cao H, Ji Y, Pei Y, Yu Z, Quan Y*, Xiang M*. Interaction of dendritic cells and T lymphocytes for the therapeutic effect of Dangguiliuhuang decoction to autoimmune diabetes. Sci Rep. 2015 Sep 11; 5:13982. doi: 10.1038/srep13982. Cao H, Ji Y, Li W, Liu Y, Fu R, Xiang M*. Protective Effects of the Total Coumarin Fraction of Urtica dentata on Experimental Diabetic Nephropathy In Vitro and In Vivo. Planta Med. 2015 Oct; 81(15):1353-60. doi: 10.1055/s-0035-1557866. Yin G, Du J, Cao H, Liu X, Xu Q, Xiang Ming*. Reg3g Promotes Pancreatic Carcinogenesis in a Murine Model of Chronic Pancreatitis. Digest Dis Sci. 2015 Dec; 60(12):3656-68. doi: 10.1007/s10620-015-3787-5. Wang J, Zhou H, Han Y, Liu X, Wang M, Wang X, Yin G, Li X, Xiang M*. SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer. J Mol Med. 2014 Jul 5; 92(12):1257-69. doi: 10.1007/s00109-014-1184-8. Wang J, Xiang M*.Targeting potassium channels Kv1.3 and KC a 3.1: routes to selective immune modulators in autoimmune disorder treatment? Pharmacotherapy. 2013 May;33(5):515-28. Wang J, Lu J, Lan Y, Zhou H, Li W, Xiang M*. Total coumarins from Urtica dentata Hand prevent murine autoimmune diabetes via suppression of the TLR4-signaling pathways. J Ethnopharmacol. 2013 Mar 7;146(1):379-92. Xiang M, Lu J, Zhang C, Lan Y, Zhou H, Li X, Peng W. Identification and quantification of total coumarins from Urtica dentata Hand and its roles in promoting immune tolerance via TLR4-mediated dendritic cell immaturation. Biosci. Biotechnol. Biochem. 2013 Jun 23;77(6):1200-6.