蔡晓凤 - 华中科技大学

个人简介

蔡晓凤，女，出生于1983年11月，博士，教授，博士生/硕士生导师。现任职于华中科技大学同济医学院药学院。2013年博士毕业于德国波恩大学，师从天然产物合成生物学领域国际知名专家Prof. Dr. Jörn Piel（现任职于苏黎世联邦理工大学，https://micro.biol.ethz.ch/research/piel.html），2014年2月-2018年10月在德国法兰克福大学天然产物合成生物学领域著名专家Prof. Dr. Helge B. Bode教授（现任职于德国马普所陆地微生物所所长https://www.mpi-marburg.mpg.de/962325/Helge-Bode）实验室从事博士后研究。工作经历 2018.10-至今教授，华中科技大学,同济医学院药学院 2014.2－2018.10 博士后，德国法兰克福大学（Prof. Dr. Helge B. Bode）教育背景 2009.11－2013.10博士,德国波恩大学，生物学（Prof. Dr. Jörn Piel） 2006.09－2009.06 硕士，华中师范大学，微生物学（李爱英教授，现就职于山东大学微生物技术国家重点实验室） 2003.09－2006.06 本科，山西大学，化学教育

研究领域

微生物来源天然产物的生物合成及合成生物学研究

近期论文

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Tao,Q., Sang,Y., Han,T., Zhou,H., Zhang,P * and Cai,X.* (2023). 20-nor-Isopimarane and isopimarane diterpenoids produced by Aspergillus sp. WT03. Org. Biomol. Chem. https://doi.org/10.1039/D3OB00005B (*,co-corresponding author,IF:3.890) Cai,X.*,＃ Zhao,L.＃ and Bode,H.B.* (2023). Engineering of specific single-module nonribosomal peptide synthetases of the RXP type for the production of defined peptides. ACS Synth. Biol.12 （1）：203-212 (*,co-corresponding author, #,co-first author,IF:5.249) Cai,X.,＃ Li,C.,＃Ichinose,K.,＃ Yali Jiang,Y., Liu,M., Wang,H., Gong,C., Li,L., Wan,J., Zhao,Y., Yang,Q. and Li, A.* (2021). A single-domain small protein Med-ORF10 regulates the production of antitumour agent medermycin in Streptomyces. Microb. Biotechnol. 14(5):1918-1930. (#,co-first author,IF:6.575) Cai, X., Taguchi, T.,Wang, H., Yuki,M.,Tanaka, M., Gong, K., Xu, J., Zhao, Y.,Ichinose, K.* and Li, A.* (2021). Identification of a C-Glycosyltransferase Involved in Medermycin Biosynthesis. ACS Chem. Biol. 16 (6), 1059–1069 (IF: 5.101) Neubacher, N., Tobias, N. J., Huber, M., Cai, X., Glatter, T., Pidot, S. J., Stinear, T. P., Lütticke, A. L.,Papenfort, K., and Bode, H. B.* （2020）. Symbiosis, virulence and natural-product biosynthesis in entomopathogenic bacteria are regulated by a small RNA. Nat. Microbiol. 5, 1481–1489. (IF:30.964) 陶巧巧, 蔡晓凤* （2020）. 诺卡菌来源活性次级代谢产物. 中国抗生素杂志. 45 (09), 833-849.( *,通讯作者) Cai, X., Zhao, L. and Bode, H. B.* (2019). Reprogramming promiscuous nonribosomal peptide synthetases for production of specific peptides. Org. Lett. 21(7), 2116-2120. (IF: 6.072) Hacker, C.,＃Cai, X.,＃ Kegler, C., Zhao, L., A., Weickhmann, A. K., Wurm, J. P., Bode, H. B.* and Wöhnert, J.* (2018). Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS. Nat. Commun.9, 4366. (#, co-first author, IF: 17.694) Cai, X., Nowak, S., Wesche, F., Bischoff, I., Kaiser, M., Fürst, R., and Bode., H.B.* (2017). Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design. Nat. Chem. 9, 379-386. (IF: 24.274) Cai, X.,＃Shi, Y. M.,＃Pöhlmann, N., Revermann, O., Bahner, I., Pidot, S. J., Wesche, F., Lackner, H., Büchel, C., Kaiser, M., Richter, C., Schwalbe, H., Stinear, T.P., Zeeck, A., and Bode, H.B.* (2017). Structure and biosynthesis of isatropolones, bioactive amine scavenging fluorescent natural products from Streptomyces Gö66. Angew. Chem. Int. Ed. Engl. 56, 4945-4949. (#, co-first author, IF: 16.823) Cai, X., Challinor, V. L., Zhao, L., Reimer, D., Adihou, H., Grün, P., Kaiser, M., and Bode., H. B.* (2017). Biosynthesis of the antibiotic nematophin and its elongated derivatives in entomopathogenic bacteria. Org. Lett. 19, 806-809. (IF: 6.072) Cai, X., Teta, R., Kohlhaas, C., Crüsemann, M., Ueoka, R., Mangoni, A., Freeman, M. F.,* and Piel, J.* (2013). Manipulation of regulatory genes reveals complexity and fidelity in hormaomycin biosynthesis. Chem. Biol. 20, 839-846. (IF: 9.039)