陈家春 - 华中科技大学

个人简介

主要学习和工作经历 1978.10-1982.07湖北中医药大学中药学本科毕业，获学士学位； 1986.09-1989.07湖北中医药大学生药学硕士研究生毕业，获硕士学位； 2000.09-2003.06成都中医药大学中药学博士研究生毕业，获博士学位； 1989.07-2005.10湖北中医药大学历任讲师、副教授、教授； 1995.04-1996.06日本富山医科药科大学和汉药研究所客座研究员； 2004.01-2004.06日本京都大学药学研究科访问研究员； 2005.10至今华中科技大学同济药学院教授。

研究领域

研究方向：中药及天然药物的资源、品质评价与活性物质基础研究；从中药和天然产物中寻找和发现抗糖尿病药物。研究内容：1、中药蛇胆、鄂产特色中药材的资源、品质及物质基础研究。分别采用提取分离技术、HPLC分析技术、DNA指纹图谱技术、体内外药效学评价等手段研究蛇胆、麦冬、獐牙菜等传统药物的功效物质基础，对其资源与品质作出综合评价。 2、麦冬、獐牙菜中抗糖尿病天然产物的发现及其新药研究。建立麦冬类、獐牙菜属等抗糖尿病传统药物的化合物库，分别采用计算机分子对接技术、体内外药理模型筛选、胰岛素信号传导与葡萄糖代谢的分子机制等评价方法发现抗糖尿病的先导化合物，在此基础上进入新药研究程序。

近期论文

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24.Yajun Gong, Jie Zhang, Fei Gao, Jiewen Zhou, Zhinan Xiang, Chenggao Zhou, Luosheng Wan∗, JiachunChen∗. Structure features and in vitro hypoglycemic activities of polysaccharides from different species of Maidong. Carbohydrate Polymers, 2017,173:215–222. 23.Xinle Tan, Fei Gao1 , Hexiu Su, Yajun Gong, Jie Zhang, Mitchel A. Sullivan & Jiachun Chen∗. Genetic and Proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver. Scientific Reports, 2017,7:43556 | DOI: 10.1038/srep43556. 22.Bin Li, Guanghong Cui, GuoanShen, Zhilai Zhan, Luqi Huang, Jiachun Chen∗ & Xiaoquan Qi∗. Targeted mutagenesis in the medicinal plant Salvia miltiorrhiza. Scientific Reports, 2017, 7:43320| DOI: 10.1038/srep43320. 21.Qiuxia Min, Xinpei Cai, Weiguang Sun, Fei gao, Zhimei Li, Qian Zhang, Luo-Sheng Wan, Hua Li & Jiachun Chen∗. Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening. Scientific reports, 2017,7:44681|DOI: 10.1038/srep44681. 20.Jie Zhang, Jiao Peng, Xiaoyong Chen, Yajun Gong, Lesheng Wan, Fei Gao,Suran Gan, Feng Wei, Shuangcheng Ma, Jiachun Chen*, Jing Nie*. Rapid identification of bile acids in snake bile usingultrahigh-performance liquid chromatography with electrosprayionization quadrupole time-of-flight tandem mass spectrometry. Journal of Chromatography B, 2016， 1036:157–169 19.Yao-Dong Yue, Yu-Tang Zhang, Zhao-Xia Liu, Qiu-Xia Min, Luo-ShengWan, Yong-LongWang, Zuo-Qi Xiao,Jia-Chun Chen*.Xanthone Glycosides from Swertia bimaculata withα-Glucosidase Inhibitory Activity.Planta Med2014; 80: 1-7 18.Zhaoxia Liu, Luosheng Wan, Yuedong Yue, Zuoqi Xiao, Yutang Zhang, Yonglong Wang, Cuiping Chen, Qiuxia Min, andJiachun Chen*.Hypoglycemic Activity and Antioxidative Stress of Extracts and Corymbiferin from Swertia bimaculata In Vitro and In Vivo.Evidence-Based Complementary and Alternative Medicine,Volume 2013,Article ID 125416, doi: 10.1155/2013/125416 17.Yong-Long Wang, Zuo-Qi Xiao, Shan Liu, Luo-Sheng Wan, Yao-Dong Yue, Yu-Tang Zhang,Zhao-Xia Liu,Jia-Chun Chen*. Antidiabetic effects of Swertia macrosperma extracts in diabetic rats.Journal of Ethnopharmacology,150 (2013) 536–544 16.Zuo-qi Xiao, Yong-long Wang, Su-ran Gan andJia-chun Chen*.Polysaccharides from Liriopes Radix ameliorates hyperglycemia via various potential mechanisms in diabetic rats.Journal of the Science of Food and Agriculture.Article first published online:10 SEP 2013, DOI: 10.1002/jsfa.6347 15.Zuo-qi Xiao,Yong-long Wang,Yao-dong Yue,Yu-tang Zhang,Cui-ping Chen,Luo-sheng Wan,Bin Deng,Zhao-xia Liu,Jia-chun Chen*.Preventive effects of polysaccharides from Liriope spicata var. prolifera on diabetic nephropathy in rats.InternationalJournal of Biological Macromolecules61 (2013):114–120 14.Luo-Sheng Wan,Ting-Ting Liu,Xiao-Jun Lin,Qiu-Xia MinandJia-Chun Chen*.Two New Chiratane-Type Triterpenoids from Swertia kouitchensis.Molecules,2013,18(7),8518-8523 13.Luo-Sheng Wan, Qiu-Xia Min, Yong-Long Wang, Yao-Dong Yue, andJia-Chun Chen*.Xanthone Glycoside Constituents of Swertia kouitchensis with α-Glucosidase Inhibitory Activity.Journal of Natural Products,2013,76(7)：1248–1253 12.Luo-sheng Wan, Cui-ping Chen, Zuo-qi Xiao, Yong-long Wang, Qiu-xia Min, Yuedong Yue,Jiachun Chen*In vitro and in vivo anti-diabetic activity ofSwertia kouitchensisextract.Journal of Ethnopharmacology147(2013):622–630 11.Yihui Liu, Luosheng Wan, Zuoqi Xiao, JingjingWang, Yonglong Wang, andJiachun Chen*.Antidiabetic Activity of Polysaccharides from Tuberous Root ofLiriope spicatavar. proliferain KKAy Mice.Evidence-Based Complementary and Alternative Medicine.2013, Article, ID 349790, 11 pages 10.JiachunChen, Xianghong Chen,Yihui Liu. Anti-diabetic material foundation of tuberous root of Liriope spicata var. prolifera. 1st International Symposium on Functional Foods in Toyama，Japan. 2010, 01: 22-24 9.L.-Y.Tian, X.Bai, X.-H.Chen, J.-B.Fang, S.-H.Liu,J.-C.Chen*. Anti-diabetic effect of methylswertianin and bellidifolin fromSwertia puniceaHemsl. and its potential mechanism.Phytomedicine(2010), 17：533-539. 8.Xianghong Chen, Yihui Liu, Xue Bai, Li Wen, Jinbo Fang, Mao Ye andJiachun Chen*.Hypoglycemic Polysaccharides from the Tuberous Root ofLiriope spicata. Journal of Natural Products,2009,72(11):1988-1994 7.Luanyuan Tian,Jiachun Chen*,Zhou Qun, Jinbo Fang. Simultaneous Determination of Four Active Components inSwertiaby RP-HPLC .Chin J Nat Med.2008, 6 (6):444-449 6.Xue Bai, Xianghong Chen, , Qun Zhou, Shenghong Liu, Jinbo Fang,Jiachun Chen*.Effects of water extract and crude polysaccharides fromLiriope spicatavar.proliferaon InsR/IRS-1/PI3K pathway and glucose metabolism in mice.Journal of Ethnopharmacology2009,125(3):482–486. 5.Qun Zhou, Jianqiu ZhouJiachun Chen*& Xiaogang Wang. Karyotype analysis of medicinal plantLiriope spicatavar.prolifera(Liliaceae).Biologia, Section Botany2009,64(4):680-683.