王凯平 - 华中科技大学

个人简介

1991年同济医科大学药学院药学本科毕业留校任教至今，期间于1997年获药学硕士学位，2007年获药学博士学位。

研究领域

药物制剂及其生物效应；新药开发及其研制；植物多糖活性物质及其作用机制；植物多糖肝靶向作用及肝靶向载体的可行性研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. A sensitive and rapid radiolabelling method for the in vivo pharmacokinetic study of lentinan. Food Funct., 2018, 9, 3114-3125.（本期封面文章） 2. Functional polysaccharide Lentinan suppresses human breast cancer growth via inducing autophagy and caspase-7-mediated apoptosis. Journal of Functional Foods. June 2018, 75–85 3. Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro. International Journal of Biological Macromolecules .2018 May;111:1133-1139 4. Dendrobium officinale polysaccharide attenuates type 2 diabetes mellitus via the regulation of PI3K/Akt-mediated glycogen synthesis and glucose metabolism. Journal of Functional Foods. January 2018, Pages 261-271 5. Pharmacokinetics, biodistribution and receptor mediated endocytosis of a natural Angelica sinensis polysaccharide. Artificial Cells, Nanomedicine, and Biotechnology. 2018 Jan 1:1-10. 6. Investigation of the transport and absorption of Angelica sinensis polysaccharide through gastrointestinal tract both in vitro and in vivo. Drug Delivery. 2017 Nov;24(1):1360-1371. 7. Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-κB Activation, Oxidative Medicine and Cellular Longevit, Volume 2017,13 pages. 8. Silkworm feces extract improves iron deficiency anemia via suppressing hepcidin expression and promoting iron-regulatory proteins expression. RSC Adv.2017,7,50378–50388 9. A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice，oncotarget. 2017 Jan 3; 8(1): 610–623 10. Protective effects of Angelica sinensis polysaccharide against hyperglycemia and liver injury in multiple low-dose streptozotocininduced type 2 diabetic BALB/c mice, Food &Function. 2016,7, 4889-4897 11. Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice, Sci. Rep. 2016,6:26229 12. Polysaccharide from Lentinus edodes combined with oxaliplatin possesses the synergy and attenuation effect in hepatocellular carcinoma, cancer letters. 2016,377:117-125 13. Structural characterization and in vitro antitumor activity of an acidic polysaccharide from Angelica sinensis (Oliv.) Diels. Carbohydrate Polymers. 2016,147:401-408 14. The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice. Food & Function. 2016,7:1033-1039 15. Angelica sinensis polysaccharide attenuates concanavalin A-induced liver injury in mice. International Immunopharmacology. 2016,31:140-148 16. Induction of apoptosis in S180 tumour bearing mice by polysaccharide from Lentinus edodes via mitochondria apoptotic pathway. Journal of functional foods. 2015,15:151-159. 17. Angelica sinensis polysaccharide regulates glucose and lipid metabolism disorder in prediabetic and streptozotocin-induced diabetic mice through the elevation of glycogen levels and reduction of inflammatory factors. Food & Function. 2015,6:902-909. 18. The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by polysaccharides from Angelica sinensis in rats with iron deﬁciency anemia. Food & Function,2014,5:1381-1388. 19. Structural differences and conformational characterization of five bioactive polysaccharides from Lentinus Edodes. Food Research International, 2014,62:223-232.