个人简介

Ph.D., 2002 University of California, Berkeley

研究领域

Organic, Materials and Biochemistry

Macromolecular Architecture: The primary focus of the group involves control of nanoscale architecture through synthetic chemistry, focusing on tailoring nanomaterials towards application to real world problems. This can be carried out using a number of preparative tools, including traditional organic synthesis, polymer chemistry, dendrimer chemistry, and self-assembly—and most often a combination of two or more. Material Applications: After decades of optimizing “top down” photolithographic patterning of polymer films for production of microelectronic devices, the existing process appears to be reaching fundamental limits. The ability to build structures in a “bottom up” fashion offers an attractive alternative to lithographic approaches but remains largely unexplored. By controlling the assembly of nanoscale materials through mechanisms such as DNA binding, hydrophobic/hydrophilic interactions, and electrostatic attraction, we hope to investigate new methodologies for building defined architectures on the 1-50 nm length scale. Incorporation of functional materials, such as organic conductors, nanocrystals, nanowires, and nantubes represent the long term goal for useful materials. Medical Applications: The ability to control materials' nano-architecture also represents a useful tool for medical applications. For example, recent work has demonstrated that polymer drug conjugates offer selective uptake into cancer tissues offering a powerful passive targeting mechanism to greatly enhance the efficacy of drugs in cancer therapy. Similarly it is expected that the study and optimization of tailored macromolecules will yield useful vectors for a wide variety of medical treatments including gene, vaccine and drug delivery. Through collaborations with the Tulane medical school, nanomaterials will be designed, synthesized, and tested, in order to optimize their structure and probe their biological properties.

近期论文

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Perez, Ricardo A.; Lopez, Juan V.; Hoskins, Jessica N.; Zhang, B.; Grayson, Scott M.; Casas, Maria T.; Puiggali, J.; Muller, Alejandro J. “Nucleation and antinucleation effects of functionalized carbon nanotubes on cyclic and linear poly(-caprolactones)” Macromolecules, 2014, 47, 3553-3566. DOI: 10.1021/ma5005869 (pdf link) Puli, Venkata S.; Elupula, Ravinder, Riggs, Brian C.; Grayson, Scott M.; Katiyar, Ram S.; Chrisey, Doug B. “Surface modified BaTiO3-polystyrene nanocomposites for energy storage.” Int. J. Nanotechnol. 2014, 11, 910-920. DOI: 10.1039/C4CC01372G Liu, L.; Parameswaran, S.; Sharma, A.; Grayson, S. M.; Ashbaugh, H. S.; Rick, S. W. “Molecular dynamics simulations of linear and cyclic amphiphilic polymers in aqueous and organic environments” J. Phys Chem B. 2014, 118, 6491-6497. DOI: 10.1021/jp412184h (pdf link) Sreerama, Subramanya, G.; Elupula, R.; Laurent, Boyd A.; Zhang, B.; Grayson, Scott M. “Use of MALDI-ToF MS to elucidate the structure of oligomeric impurities formed during ‘click’ cyclization of polystyrene” React. Func. Polym. 2014, 80, 83-94 (special issue on cyclic polymers) DOI: 10.1016/j.reactfunctpolym.2014.01.013 (pdf link) Pérez, Richardo A.; Córdova, Miguel E.; López, J.; Hoskins, Jessica N.; Zhang, Boyu; Grayson, Scott M.; Müller, Alejandro J. “Nucleation, crystallization, self-nucleation and thermal fractionation of cyclic and linear poly(-caprolactone)s” React. Func. Polym. 2014, 80, 71-82. (special issue on cyclic polymers) DOI: 10.1016/j.reactfunctpolym.2013.10.013 (pdf link) Ejaz, Muhammad.; Rai, Satish C.; Wang Kai; Zhang, Karen; Zhou, Weilie; Grayson, Scott M. “Surface initiated atom transfer radical polymerization of glycidyl methacrylate and styrene from boron nitride nanotubes.” J. Mater. Chem. C. 2014, 2, 4073-4079. DOI: 10.1039/C3TC32511C (pdf link) Zhang, Boyu; Zhang, Hong; Myers, Brittany M.; Elupula, Ravinder; Jayawickramarajah, Janarthanan; Grayson, Scott M. “Determination of polyethylene glycol end group functionalities by combination of selective reactions and characterization by matrix assisted laser desorption/ionization time of flight mass spectrometry.” Anal. Chim. Acta. 2014, 816, 28-40. DOI: 10.1016/j.aca.2014.01.039 (pdf link) Zhang, Hong; Zhang, Boyu; Zhu, M.; Grayson, Scott M.; Schmehl, R. H.; Jayawickramarajah, Janarthanan. “Water-soluble porphyrin nanospheres: enhanced photo-physical properties via cyclodextrin driven double self-inclusion.” Chem. Commun. 2014, 50, 4853-4855. DOI:10.1039/C4CC01372G (pdf link) Zhang, Boyu; Zhang, Hong; Elupula, Ravinder, Alb, Alina M.; Grayson, Scott M. “Efficient Synthesis of High Purity Homo-arm and Mikto-arm Poly(ethylene Glycol) Stars Using Epoxide and Azide-Alkyne Coupling Chemistry” Macromol. Rapid Commun. 2014, 35, 146-151 DOI: 10.1002/marc.201300623 (pdf link) Grayson, Scott M.; Myers, Brittany K.; Bengtsson, Jonas; Malkoch, Michael “Advantages of Monodisperse and Chemically Robust “SpheriCal” Polyester Dendrimers as a “Universal” MS Calibrant. J. Am. Soc. Mass Spectrom. 2014, 25, 303-309: DOI: 10.1007/s13361-013-0777-8 (pdf link) Myers, Brittany K.; Zhang, Boyu; Lapucha, Joanna E.; Grayson, Scott M. “The Characterization of Dendronized Poly(ethylene Glycol)s and Poly(ethylene Glycol) Multiarm Stars Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry.” Anal. Chim. Acta, 2014, 808, 175-189. DOI: 10.1016/j.aca.2013.09.038 (pdf link) Wang, Yi; Alb, Alina O.; He, Jibao; Grayson, Scott M.”Neutral Amphiphilic Linear Homopolymers Prepared by Atom Transfer Radical Polymerization” Polym. Chem., 2014, 5, 622-629. DOI: 10.1039/C3PY00916E (pdf link) Zhang, B.; Zhang, H.; Li, Y.; Hoskins, J. N.; Grayson, S. M. “Exploring the Effect of Amphiphilic Polymer Architecture: Synthesis, Characterization, and Self-Assembly of Both Cyclic and Linear Poly(ethylene gylcol)-b-polycaprolactone.” ACS Macro Lett. 2013, 2, 845–848. (pdf link) Myers, B. M., Lapucha, J. E.; Grayson, S. M. “Synthesis and MALDI-ToF characterization of dendronized poly(ethylene glycol)s.” Braz. J. Pharm. Sci. 2013, 49, 45-55. Ejaz, M.; Sunkara, B.; Kamboj, L.; He, J.; John, V. T.; Pesika, N. S.; Grayson, S. M. “Facile one-pot method of initiator fixation for surface-initiated atom transfer radical polymerization on carbon hard spheres.” J. Polym. Sci. Part -Polym. Chem. 2013, 51, 3314–3322. (pdf link) Su, H.-H.; Chen, H.-L.; Diaz, A.; Teresa Casas, M.; Puiggali, J.; Hoskins, J. N.; Grayson, S. M.; Perez, R. A.; Mueller, A. J. “New insights on the crystallization and melting of cyclic PCL chains on the basis of a modified Thomson-Gibbs equation.” Polymer 2013, 54, 846–859. (pdf link) Yol, A. M.; Dabney, D. E.; Wang, S.-F.; Laurent, B. A.; Foster, M. D.; Quirk, R. P.; Grayson, S. M.; Wesdemiotis, C. “Differentiation of Linear and Cyclic Polymer Architectures by MALDI Tandem Mass Spectrometry (MALDI-MS2).” J. Am. Soc. Mass Spectrom. 2013, 24, 74–82. (pdf link) Grayson, S. M. “A Simple Visualization of Double Bond Properties: Chemical Reactivity and UV Fluorescence.” J. Chem. Educ. 2012, 89, 925–927. (pdf link) Wang, Y.; Grayson, S. M. “Approaches for the preparation of non-linear amphiphilic polymers and their applications to drug delivery.” Adv. Drug Deliv. Rev. 2012, 64, 852–865. (pdf link) Li, Y.; Zhang, B.; Hoskins, J. N.; Grayson, S. M. “Synthesis, purification, and characterization of ‘perfect’ star polymers via ‘Click’ coupling.” J. Polym. Sci. Part -Polym. Chem. 2012, 50, 1086–1101.