李智涛 - 河南科技大学

个人简介

现任河南科技大学医学院免疫学教研室副主任，副教授、高级工程师，硕士生导师。1988年于河南医科大学获得医学学士，1994年于北京医科大学获得医学硕士。2010年于郑州大学获得医学博士。长期在企业一线从事研发和生产工作，历任研发工程师、研究室副主任和技术总监等，熟悉基因工程制备蛋白和体外诊断试剂的生产和研发，现为河南省医疗器械生产企业现场核查员，获国家国内贸易部科技进步二等奖1项，河南省科技进步二等奖3项，国家发明专利2项，发表论文50余篇，参与9种国家新药的研发和报批工作并获得国家新药证书。目前重要从事免疫学教学科研，

研究领域

研究方向肿瘤免疫和单抗的制备，也进行干细胞的相关研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Guomin Shen,Shuang Li, Weidong Cui, Shixuan Liu, Qian Liu, Yihu Yang, Michael Gross, and Weikai Li*. Stabilization of warfarin-binding pocket of VKORC1 and VKORL1 bya peripheral region determines their different sensitivity to warfarininhibition. Journal of Thrombosis andHaemostasis. 2018, 16(6):1164-1175. CoverStory 2. Guomin Shen,Shuang Li, Weidong Cui, Shixuan Liu, Yihu Yang, Michael Gross, and Weikai Li*. Membraneprotein structure in live cells: Methodology for studying drug interaction bymass spectrometry-based footprinting. Biochemistry.2018,23;57(3):286-294. 3. Shuang Li, Guomin Shen, Weikai Li*.Intramembrane Thiol Oxidoreductases: Evolutionary Convergence and StructuralControversy. Biochemistry. 2018 23;57(3):258-266. 4. Guomin Shen＊, Weidong Cui＊, Hao Zhang, Fengbo Zhou, Wei Huang, YihuYang, Qian Liu, Greg Bowman, Evan Sadler, Michael Gross, Weikai Li. Warfarintraps human vitamin K epoxide reductase in an intermediate state duringelectron transfer. Nature Structural & Molecular Biology,2017 Jan;24(1):69-76. （＊:Co-first author, Featured in News and Views ） 5. Tianzhen Wang, Peng Han, Yan He, Ci Zhao, Guangyu Wang, WeiweiYang, Ming Shan4, Yuanyuan Zhu, Chao Yang, Mingjiao Weng, Di Wu, Lin Gao,Xiaoming Jin, Yunwei Wei, BinBin Cui＃, Guomin Shen＃, Xiaobo Li＃ Lin28A enhanceschemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in alet-7 independent manner. Tumour Biol, 2016, Jun ; 37(6) :7657-65.(＃ Co-corresponding author) 6. GuominShen＃, Ning Ning, Xingsheng Zhao, Xi Liu, Guangyu Wang, Tianzhen Wang,Ran Zhao, Dongmei Wang, Pingyuan Gong, Yan Shen, Yongjian Sun, Xiao Zhao, YinjiJin, Weiwei Yang, Yan He, Lei Zhang, Xiaoming Jin, Xiaobo Li＃. Adiposedifferentiation-related protein (ADRP) is not involved in hypoxia induciblefactor-1(HIF1) induced lipid accumulation under hypoxia. MolecularMedicine Reports. 2015, Dec;12(6):8055-61. (＃ Co-corresponding author) 7.Guomin Shen, Xiaobo Li, Yong-feng Jia, Gary A Piazza,Yaguang Xi. Hypoxia-regulated microRNAs in humancancer. Acta Pharmacol Sin. 2013, Mar;34(3):336-341. 8.Guo-MinShen, Ying-Ze Zhao, Ming-Tai Chen, Feng-Lin Zhang, Xiao-Ling Liu,Yi Wang, Chang-Zheng Liu, Jia Yu, Jun-Wu Zhang. Hypoxia Inducible Facter 1(HIF1) Promotes LDL and VLDL Uptake Through Inducing VLDLR Under Hypoxia. BiochemJ, 2012, Jan; 441(2):675-683. 9. Guo-MinShen, Feng-Lin Zhang, Xiao-Ling Liu, Jun-Wu Zhang.Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogenaccumulation in human MCF-7 cells under hypoxia. FEBS Lett. 2010,584(20):4366-4372. 10.Shixuan Liu, Wei Cheng, Ronald Fowle-Grider, GuominShen, and Weikai Li. Structures of an intramembrane vitamin Kepoxide reductase homolog reveal control mechanisms for electron transfer. NatureCommunication. 2014; 5: 3110. doi: 10.1038/ncomms4110. 11. Feng-Lin Zhang, Guo-MinShen, Xiao-Ling Liu, Fang Wang, Jun-Wu Zhang. Hypoxia-inducible factor 1-mediated human GATA1 induction promoteserythroid differentiation under hypoxic conditions. J Cell Mol Med,2012, Aug; 16(8):1889-1899 . 12. Feng-LinZhang,Guo-Min Shen, Xiao-Ling Liu, FangWang, Hua-Lu Zhao, Jia Yu, Jun-Wu Zhang. HypoxicInduction of Human Erythroid-Specific Delta-Aminolevulinate Synthase Mediatedby Hypoxia-Inducible Factor 1. Biochemistry, 2011, 50 (7): 1194–1202. 13.Ying-Ze Zhao,Xiao-Ling Liu, Guo-Min Shen, Yan-Ni Ma, Feng-Lin Zhang,Ming-Tai Chen, Hua-Lu Zhao, Jia Yu, Jun-Wu Zhang. Hypoxia induces peroxisomeproliferator-activated receptor γ expression via HIF-1-dependent mechanisms inHepG2 cell line. Archives of Biochemistry and Biophysics.2014;543:40-47. 14. Pingyuan Gong,Guomin Shen, She Li, Guoping Zhang, Hongchao Fang, LinLei, Peizhe Zhang, Fuchang Zhang. Genetic Variations in COMT and DRD2 ModulateAttentional Bias for Affective Facial Expressions.PLoSOne. 2013, Dec 2;8(12):e81446. 15.Pingyuan Gong, Shoumin Xi, She Li, Guochang Cao, Peizhe Zhang, GuominShen, Fuchang Zhang, Yan Shen, and Hua Ma. Effect of Val66Metpolymorphism in BDNF on attentional bias in an extroverted Chinese Hanpopulation. Acta Neurobiol Exp (Wars). 2013;73(2):280-8. 16.Pingyuan Gong, Shoumin Xi, Guomin Shen, She Li, PeizheZhang, Guochang Cao, Fuchang Zhang, Yan Shen, Tiantian Feng, Hua Ma. Theeffects of DBH, MAOA, and MAOB on attentional biases for facial expressions. JMol Neurosci. 2013, Mar;49(3):606-131.