谢松强 - 河南大学

个人简介

受教育经历 (Educational Experience)（从大学本科开始，按时间倒排序）：　　2005/09 – 2008/07, 沈阳药科大学博士研究生　　2000/09 – 2003/07, 郑州大学医学院硕士研究生　　1994/09 – 1997/07, 开封医学高等专科学校工作经历(Professional Experience)（按时间倒排序）：　　2012/12 – 河南大学，药学院，教授；　　2008/12 – 2012/12, 河南大学，药学院，副教授；　　2005/11 – 2008/12, 河南大学，药学院，讲师；

研究领域

肿瘤药理学：近年来主要进行多胺与肿瘤发生、发展及转移的分子机制研究，以及针对多胺为靶点的抗肿瘤药物研究。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1）Li M, Li Q, Zhang YH, Tian ZY, Ma HX, Zhao J, Xie S*, Wang CJ*. Antitumor effects and preliminary systemic toxicity of ANISpm in vivo and in vitro. Anticancer Drugs. 2013，24(1):32-42.　　2）Li YK, Yang M, Li MX*, Yu H, Wu HC, Xie S*. Synthesis, crystal structure and biological evaluation of a main group seven-coordinated bismuth(III) complex with 2-acetylpyridine N4-phenylthiosemicarbazone. Bioorg Med Chem Lett. 2013, 23(8):2288-92.　　3) Wang Y, Zhang X, Zhao J, Xie S*, Wang C*. Nonhematotoxic naphthalene diimide modified by polyamine: synthesis and biological evaluation. J Med Chem. 2012, 55(7):3502-12.　　4) Xie S, Zhang Y, Li Q, Xu F, Miao J, Zhao J, Wang C. 3-Nitro-naphthalimide and nitrogen mustard conjugate NNM-25 induces hepatocellular carcinoma apoptosis via PARP-1/p53 pathway. Apoptosis 2012, 17(7):725-34.　　5) Xie S, Zhang Y, Li Q, Wang J, Li J, Zhao J, Wang C. COX-2-independent induction of apoptosis by celecoxib and polyamine naphthalimide conjugate mediated by polyamine depression in colorectal cancer cell lines. Int J Colorectal Dis. 2012, 27(7):861-8.　　6) Xie S, Li Q, Zhang Y, Li Z, Zhao J, Wang C. BND-12, a novel nonhematotoxic naphthalimide derivative, inhibits tumor growth and metastasis of hepatocellular carcinoma. J Pharm Pharmacol. 2012, 64(10):1483-90.　　7) Xie S, Li Q, Zhang Y, Wang J, Mei Z, Zhao J, Wang C. NPC-16, a novel naphthalimide-polyamine conjugate, induced apoptosis and autophagy in human hepatoma HepG2 cells and Bel-7402 cells. Apoptosis 2011, 16: 27-34.　　8) Xie S, Wang J, Zhang Y, Wang C. Antitumor conjugates with polyamine vectors and their molecular mechanisms. Expert Opin Drug Deliv 2010, 7(9):1049-61 (Invited Review).　　9) Xie S, Wang J, Ma H, Cheng P, Zhao J, Wang C. Polyamine transporter recognization and antitumor effects of anthracenymethyl homospermidine. Toxicology, 2009, 263 (2-3): 127-133.　　10) Tian Z, Xie S, Mei Z, Zhao J, Gao W, Wang C. Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway. Org Biomol Chem, 2009, 7(22): 4651-4660 (Highlights in Chemical Biology, Issue 12, 2009).　　11) Tian Z, Xie S, Du Y, Ma Y, Zhao J, Gao W, Wang C. Synthesis, cytotoxicity and apoptosis of naphthalimide polyamine conjugates as antitumor agents. Eur J Med Chem, 2009, 44 (1): 393-399.