王磊 - 河北医科大学

个人简介

本科及硕士毕业于中国药科大学药物化学专业，博士毕业于美国Duquesne University药物化学专业。主讲课程包括药学本科《药物化学》、《有机化学》、《药学导论》及研究生《新药开发与现代化研究》。近五年主持多项科研课题，其中国家自然科学基金1项、教育部科学技术研究重点项目1项，中国博士后基金面上项目及特别资助各1项、教育部及河北省留学回国基金各1项、河北省自然科学基金1项及河北省教育厅科学技术研究重点项目1项，申请新化合物发明专利1篇，发表SCI科技论文10余篇，其中第一作者4篇（JMC，5.589），通讯作者2篇（EJMC，3.902）。2015年入选河北省“三三三人才工程”第三层次人选，2016年被评为河北医科大学“十二五”以来教学先进个人。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Liu, Y.; Li, M.; Zhang, H.; Yuan, J.; Zhang, C.; Zhang, K.; Guo, H.; Zhao, L.; Du, Y.; Wang, L.*; Ren, L.* Design, Synthesis and Biological Evaluation of 6-Substituted Pyrrolo[2,3-d]pyrimidines as Dual Inhibitors of TS and AICARFTase and as Potential Antitumor Agents. European Journal of Medicinal Chemistry, 2016, 115, 245-256. 2. Liu, Y.; Zhang, C.; Zhang, H.; Li, M.; Yuan, J.; Zhang, Y.; Zhou, J.; Guo, H.; Zhao, L.; Du, Y.; Wang, L.*; Ren, L.* Synthesis and Antitumor Activity of 6-Substituted Pyrrolo[2,3-d]pyrimidines as Potential Nonclassical Antifolates Targeting both Thymidylate and Purine Nucleotide Biosynthesis. European Journal of Medicinal Chemistry, 2015, 93, 142-155. 3. Wang, L.; Wallace, A.; Raghavan, S.; Deis, S.M.; Wilson, M.R.; Yang, S.; Polin, L.; White, K.; Kushner, J.; Orr, S.; George, C.; O'Connor, C.; Hou, Z.; Mitchell-Ryan, S.; Dann, C.E. 3rd; Matherly, L.H.*; Gangjee, A.* 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors. Journal of Medicinal Chemistry, 2015, 58, 6938-6959. 4. Wang, L.; Cherian, C; Kugel-Desmoulin, S.; Mitchell-Ryan, S; Hou, Z.; Matherly, L. H. and Gangjee, A. Synthesis and Biological Activity of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Inhibitors of de Novo Purine Biosynthesis with Selectivity for Cellular Uptake by High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier. Journal of Medicinal Chemistry, 2012, 55, 1758-1770. 5. Wang, L.; Kugel-Desmoulin, S.; Cherian, C; Polin, L.; White, K.; Kushner, J.; Fulterer, A.; Chang, M.; Mitchell-Ryan, S.; Stout, M.; Romero, M. F.; Hou, Z.; Matherly, L. H. and Gangjee, A. Synthesis, Biological and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter and Folate Receptor Selectivity over the Reduced Folate Carrier That Inhibits β-Glycinamide Ribonucleotide Formyltransferase. Journal of Medicinal Chemistry, 2011, 54, 7150–7164. 6. Wang, L.; Cherian, C; Kugel-Desmoulin, S.; Polin, L.; Deng, Y.; Wu, J.; Hou, Z.; White, K.; Kushner, J.; Matherly, L. H. and Gangjee, A. Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier for Cellular Entry. Journal of Medicinal Chemistry, 2010, 53, 1306–1318.