刘玉欣 - 河北大学

个人简介

河北大学药学院教授，河北省药品质量控制重点实验室细胞药理分室主任。82年毕业于南开大学生物系。曾先后在大连水产学院；天津农业科学院；大连医药科学研究所，大连理工大学从事教学与研究工作。2000年赴美国NIEHS/NIH、UNC从事细胞与分子神经药理学研究，2008年回国到河北大学药学院从事教学和研究工作。回国后与杨更亮教授一起合作开展3-取代亚甲基硫色满-4-酮类新化合物的抗癌新药研究，现为国家重大新药创制专项课题《3-取代亚甲基硫色满-4-酮类抗肿瘤新药研究》课题负责人。

近期论文

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1.Yanan Yuan，Shiru Liang，Hongyuan Yan，Zhengyue Ma andYuxin Liu. Ionic liquid-molecularly imprinted polymers for pipette tip solid-phase extraction of (Z)-3-(chloromethylene)-6-flourothiochroman-4-one in urine.Journal of Chromatography A, 2015,1408,49-55. 2.Pengpeng Tian, Xuemin Zhang, Yuanyuan Guo, Yanping Wang, Yuemin zhao andYuxin Liu. (Z)-3-(chloromethylene)-6-methylthiochroman-4-one increased proinflammatory factors production in mice macrophages.Journal of Chemical and Pharmaceutical Research，2015.Vol.7(7)570-576 3.Yuemin Zhao, Chunna Li, Haitao Suo, Yanping Wang, Chunliu Yang, Zhengyue Ma andYuxin Liu.Cytotoxic effect of three novel thiochromanone derivatives on tumor cell in vitro and underlying mechanism.Global Advanced Research Journal of Medicine and Medical Science.2014.Vol. 3(9) 240-250 4.Yali Song, Yunfang Dong, Tao Yang, Chaochao Zhang, Limin Su, Xin Huang,Dongnuan Zhang , Gengliang Yang,Yuxin Liu. Synthesis and pharmacological evaluation of novel bisindolylalkanes analogues. Bioorganic & Medicinal Chemistry 21 (2013) 7624–7627 5.LiyaQin,YuxinLiu,Jau-Shyong Hong,Fulton T. Crews.NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration.Glia. 2013 Jun;61(6):855-68 6.TengfeiLiu,NanXiao,YuxinLiu,BlendaWilson,JingLi ,YuanyuanWang,XuCao,ZhiqinLiu.The anti-inflammatory effects of ethyl acetate on Lipopolysaccharide/D-galactosamine challenged mice and Lipopolysaccharide activated RAW264.7 cells.Biochem Biophys Res Commun. 2012, 427: 518-524 7.TengfeiLiu,JingLi,YuxinLiu,NanXiao,HaitaoSuo,KunXie,Chunliu Yang, Chen Wu. Short-Chain Fatty Acids Suppress Lipopolysaccharide-Induced Production of Nitric Oxide and Proinflammatory Cytokines Through Inhibition of NF-κB Pathway in RAW264.7 Cells.Inflammation.2012 35(5)1676-1684 8.黄鑫,刘玉欣,苏立敏,郝德忠,崔世怡,杨更亮;一种新硫色满酮衍生物诱导人乳腺癌MCF-7细胞凋亡;科学通报;2012, 57: 626–633 9.YuxinLiu,Yi-ching Lo,LiQian , Fulton T. Crews,BelindaWilson,Huiling Chen,HungmingWu, SH Chen,KeWei, RB Lu, S Ali, JS Hong.Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation.Neuropharmacology. 2011 Feb-Mar;60(2-3):373-80.Yuxin Liu, Huiling Chen and Gengliang Yang,Extract of Tripterygium wilfordii Hook F Protect Dopaminergic Neurons Against Lipopolysaccharide-Induced Inflammatory Damage. TheAmerican Journal of Chinese Medicin. 2010, 38(4)801-814 10.Yachen Li, Xiaoming Hu,Yuxin Liu, Yongming Bao and Lijia An.Nimodipine protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation.Neuropharmacology. 2009 Mar;56(3):580-589. Yachen Li, Yongming Bao, Bo Jiang, Zhuo Wang,Yuxin Liu, Cen Zhang and Lijia An.Catalpol protects primary cultured astrocytes from in vitro ischemia-induced damage.Int J Dev Neurosci. 2008 May-Jun;26(3-4):309-17. 11.Xiaoming Hu,DanZhang ,haoPang , Caudle WM,YachenLi,HuimingGao,YuxinLiu,LiQian,BelindaWilson, Di Monte DA, Ali SF, Zhang J, Block ML, Hong JS.Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease.J Immunol. 2008 Nov 15;181(10):7194-204. 12.Yuxin Liu,Liya Qin,BelindaWilson,Xuefei Wu, Li Qian,Ann-Charlotte Granholm, Fulton T. Crews , Jau-Shyong Hong.Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits.Neurotoxicology. 2008 Sep;29(5):864-70 13.Yi-ching Lo,Yuxin Liu,Yi-Chin Lin, Yu-Tzu Shih, Chi-Ming Liuand Leo T. Burka,Neuronal effects of 4-t-Butylcatechol: A model for catechol-containing antioxidants.Toxicol Appl Pharmacol.2008,228(2):247-55 14.Liya Qin, Xuefei Wu, Michelle Block,Yuxin Liu, George Breese, Jau-shyong Hong, Darin Knapp and Fulton T. Crews. Systemic LPS Causes Chronic Neuroinflammation and Progressive Neurodegeneration. Glia. 2007 Jan 3;55(5):453-462 15.Jing Liu, Qiao-Jie He, Wei Zou, Hong-Xia Wang, Yong-Ming Bao,Yuxin Liu, Li-Jia An, Catalpol increases hippocampal neuroplasticity and up-regulates PKC and BDNF in the aged rats. Brain Res. 2006 Dec 6;1123(1):68-79. 16.Dan-Qing Li, Yong-Ming Bao, Yang Ll, Cheng-Fang Wang,Yuxin Liuand Li-Jia An.Catalpol modulates the expressions of Bcl-2 and Bax and attenuates apoptosis in gerbils after ischemic injury.Brain Res. 1115(1):179-85. 17.Dan-Qing Li, Yang Li,Yuxin Liu, Yong-Ming Bao, Bo Hu and Li-Jia An. Catalpol prevents the loss of CA1 hippocampal neurons and reduces working errors in gerbils after ischemia-reperfusion injury. Toxicon. 2005 Dec 15;46(8):845-851.