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个人简介

1964年5月生于安徽省望江县九华村。1983年考入武汉大学化学系,并在1987年考上本校研究生。1990年毕业后在云南省化工研究院工作,从事天然香料等半合成研究。1993年考入中科院昆明植物所攻读博士研究生,师承周俊院士,并拜师香港科技大学戴伟民教授及昆明植物所郝小江教授学习手性催化剂的设计与合成。1998年前往美国密西西比州立大学学习工作,并获得Assistant Research Professor,2003年获得中科院“国外杰出人才”。2005年到美国Virginia Tech (弗吉尼亚理工)做高级访问学者。2011年作为高层人才到河北大学工作

研究领域

1. 主讲课程:有机立体化学,天然产物化学,药物化学 2. 研究方向:手性药物分离分析、计算鉴定与手性中心的有机合成控制

近期论文

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1. Li Liu, Qing Yang, He Yu, Jing-Liang Li, Yu-Ning Pei, Hua-Jie Zhu,* Zhen-Qiu Li, Xiao-Ke Wang, “Fitness of Driving Force and Catalytic Space in Chiral Catalyst Design. Application of Axial Biscarboline N-O Chiral Catalysts for Enantioselective Allylation of Allyltrichlorosilane to Bulky Substituted Aldehydes” Tetrahedron. 2015, 71, 3296-3302. 2. H. Yu, W-X Li, J.-C. Wang, Q. Yang, H.-J. Wang, C.-C. Zhang, S.-S. Ding, Y. Li, H.-J Zhu,* “Pestalotiopsin C, Stereochemistry of A New Caryophyllene from a Fungus of Trichoderma sp. and Its Tautomerization Characteristics in Solution”, Tetrahedron. 2015, 71, 3491-3494. 3. D.-B. Hu, W.-X. Li, Z.-Z. Zhao, T. Feng, R.H. Yin, Z.-H. Li, J.-K. Liu, H. J. Zhu*. “Highly unsaturated pyranone derivatives from the basidiomycete Junghuhnianitida” Tetrahedron Lett. 2014, 55, 6530-6533. 4. Jin-Liang Li, Li Liu, Yu-Ning Pei, Hua-Jie Zhu*, “Copper(II)-containing C2-symmetric bistetracarboline amides in enantioselective Henry reactions”. Tetrahedron, 2014, 70, 9077-9083. 5. Yu-NingPei, Yu Deng, Jing-Liang Li, Hua-Jie Zhu* “Chiral Biscarboline N,N'-Dioxide Derivatives Catalyzed Asymmetric Reduction of Ketoimines with Trichlorosilane” Tetrahedron Lett, 2014. 55, 2948-2952. 6. Bing Bai, Xing-Yao Li, Li Liu, Yan Li, Hua-Jie Zhu*, “Syntheses of Novel β-Carboline Derivatives and the Activities against Five Tumor-Cell Lines” . Bioorg. Med. Chem. Lett. 2014, 24, 96–98. 7. Ping He, Xiangfen Wang, Xiujie Guo, Chuanqi Zhou, Shigang Shen, Dongbao Hu, Xiaolong Yang, Duqiang Luo, Rina Dukor, Huajie Zhu* “Vibrational Circular Dichroism Study for Natural Schizandrin from Pyrola rotundifolia L. and Reassignment of Its Absolute Configuration”, Tetrahedron Lett. 2014, 55, 2965–2968. 8. Hua-Jie Zhu,* Wen-Xin Li, Dong-Bao Hu, Meng-Liang Wen, “Discussion of Absolute Configuration for Bioactive Griseusins by Comparing Computed Optical Rotations and Electronic Circular Dichroism with the Experimental Results” Tetrahedron, 2014, 70, 8236-8243. 9. Wei Pan, Dongbao Hu, He Yu, Huajie Zhu*, “Mechanism Investigation of Hydrosilylation of Ketimines with Trichlorosilane Using Asymmetric-Axle-Supported Chiral N-O Amides and Absolute Configuration Discussion for N-Substituted Aniline” ,Tetrahedron 2014, 69, 7253-7257 10. S. Zhang, D.-B. Hu, J.-B. He, K.-Y. Guan, H.-J. Zhu,* “A Novel Tetrahydroquinoline Acid and Two New Benzofuranones from Capparis spinosa L., A Case Study of Absolute Configuration Determination Using Quantum Methods” , Tetrahedron 2014, 70, 869-873 11. Jiang-Bo He, Yan-Nan Ji, Dong-Bao Hu, Shen Zhang, Hui Yan, Xin-Chun Liu, Huai-Rong Luo, Hua-Jie Zhu* “Structure and Absolute Configuration of Penicilliumine, a New Alkaloid from Penicillium commune 366606”, Tetrahedron Lett. 2014. 55, 2684-2686. 12. W. Pan, Y. Deng, J.-B. He, B. Bai, H.-J. Zhu*, “Highly Efficient Asymmetric-Axle-Supported N-O Amides in Enantioselective Hydrosilylation of Ketimines with Trichlorosilane”, Tetrahedron, 2013, 69, 7253-. 13. B.-X. Zhao, Y. Wang, C. Li, G.-C. Wang, X.-J. Huang, C.-L. Fan, Q.-M. Li, H.-J. Zhu*, W.-M. Chen*, W.-C. Ye*, “Flueggedine, a novel axisymmetric indolizidine alkaloid dimer from Flueggea virosa”, Tetrahedron Lett. 2013, 54, 4708-4711. 14. Y. Deng, W. Pan, Y.-N.Pei, J.-L. Li, X.-C. Liu H.-J. Zhu*, “Asymmetric Addition of Aldehydes with Allytrichlorosianes Catalyzed by Axial N-O Secondary Amides” Tetrahedron 2013.69.10431-10437. 15. Q.-M. Li, J. Ren, L. Shen, B. Bai Q.-M. Li, X.-C. Liu and M.-L. Wen, H.-J. Zhu*, “Determining the Absolute Configuration of Benzopyrenomycin from Optical Rotation, Electronic Circular Dichroism and Population Analysis of Different Conformations via DFT Methods”. Tetrahedron 2013,69,3067-3074. 16. J. Ren, G-L Li, L Shen, G-L Zhang, Larance Nafie, H-J Zhu,* “Challenges in the Assignment of Relative and Absolute Configurations of Complex Molecules” Tetrahedron. 2013, 69,10351-10356. 17. B-D. Zhou, J. Ren, X.-C. Liu and H.-J. Zhu* “Theoretical and Experimental Study of the Absolute Configuration of Helical Structure of (2R,3S)-Rubiginone A2 Analog” Tetrahedron. 2013, 69, 1189-1194. 18. B. Bai, H.-J. Zhu,* W. Pan, “Structure Influence of Chiral 1,1′-Biscarboline-N,N′-Dioxide on the Enantioselective Allylation of Aldehydes with Allyltrichlorosilanes” Tetrahedron. 2012. 68, 6829-6836.

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