张吉泉 - 贵州医科大学

个人简介

2015年毕业于中山大学药学院，获理学博士学位。贵州医科大学药物化学学科青年骨干教师，担任贵州省化学合成药物研发利用工程技术研究中心办公室主任，贵阳市天然产物活性成分成药性研究创新团队负责人。

研究领域

1）小分子靶向抗肿瘤药物研究；2）新型抗糖尿病药物研究；3）过渡金属参与的偶联反应研究。

近期论文

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(1) Jun Cao,Zi-Li Chen, Shu-Min Li, Gao-Feng Zhu, Yuan-Yong Yang, Cong Wang, Wen-Zhang Chen, Jian-Ta Wang, Ji-Quan Zhang*, Lei Tang*. Palladium-catalyzed regioselective C-2 arylation of benzofurans with N'-acyl arylhydrazines. European Journal of Organic Chemistry, 2018, 2018(22), 2774-2779. (2) Ji-Quan Zhang, Shu-Min Li, Xiao Ma, Gang Zhong, Rui Chen, Xiao-Shuang Li, Gao-Feng Zhu, Bo Zhou, Bing Guo, Hao-Shu Wu, Lei Tang*. Discovery of novel tetrahydrocarbazoles with potent hypoglycemic and hypolipemic activities. European Journal of Medicinal Chemistry, 2018, 150, 102-112. (3) Ji-Quan Zhang*,#, Jun Cao#, Wei Li, Shu-Min Li, Yong-Kang Li, Jian-Ta Wang, Lei Tang*.Palladium/copper-catalyzed arylation of alkenes withN′-acyl arylhydrazines. New Journal of Chemistry, 2017, 41, 437-441. (4) Ji-Quan Zhang, Yong-Jie Luo, Yan-Shi Xiong, Hui-Xuan Chen, Yu Luo, Zheng-Chao Tu, Jiang Weng, Gui Lu*. Design, synthesis and biological evaluation of substituted pyrimidines as potential PI3K inhibitors. Journal of Medicinal Chemistry, 2016, 59, 7268-7274. (5) Ji-Quan Zhang, Yan-Shi Xiong, Albert S. C. Chan, Gui Lu*. Cu(II)-catalyzed cross-dehydrogenative coupling reaction of N’-acyl arylhydrazines and phosphites. RSC. Advances, 2016, 6, 84587-84591. (6) Ji-Quan Zhang, Gong-Bin Huang, Jiang Weng, Gui Lu*, Albert S. C. Chan. Copper(II)-catalyzed coupling reaction: an efficient and regioselective approach to N’,N’-diaryl acylhydrazines. Organic & Biomolecular Chemistry, 2015, 13, 2055-2063. (7) Ji-Quan Zhang, Jian-Ta Wang, Hao-Shu Wu, Yao-Yao He, Gao-Feng Zhu, Xing Cui, Lei Tang*. Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivative.Bioorganic & Medicinal Chemistry Letters, 2009, 19, 3324-3327.