Yaacov Ben-David - 贵州医科大学

个人简介

ACADEMIC DEGREES 1978 B.Sc, Biology, University of Teaching Training, Tehran, Iran 1982 M.Sc, Molecular Virology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel 1987 Ph.D. Tumor biology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel 1991 Post doctorate fellow, Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada EMPLOYMENT HISTORY 1991- 1998 Assistant professor, Department of Medical Biophysics, University of Toronto 1991- 2006 Scientist, Molecular and Cellular Biology, Sunnybrook Research Institute, Toronto, Ontario, Canada 2006- 2012 Senior Scientist, Molecular and Cellular Biology, Sunnybrook Research Institute, Toronto, Ontario, Canada 1998- 2005 Associate professor, Department of Medical Biophysics, University of Toronto 2005- 2013 Professor, Department of Medical Biophysics, University of Toronto 2013-present Professor, Director of cancer biology platform, The state Key laboratory of Chemistry for Traditional Chinese Medicine of Guizhou and Chinese Academy of Sciences (Guizhou Medical University).

近期论文

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1. Li, Y-J., Zhao XJ, Li, Y., Vecchiarelli-Federico LM., Datti A., Cheng, Y., and Ben-David, Y. (2012). Drug-mediated inhibition of Fli-1 for the treatment of leukemia. Blood Cancer Journal, 2, e54; Epub Jan 27. 2. Li, YJ., Vecchiarelli-Federico, LM., Li, Y-J., Egan, SE., Spaner, D., Hough, MR., and Ben-David, Y. (2012) The miR-17-92 cluster expands multipotent hematopoietic progenitors whereas imbalanced expression of its individual oncogenic miRNAs promotes leukemia in mice. Blood, 119:4486-98. 3. Li, YJ, Liu, G., Li, Y., Vecchiarelli-Federico, LM., Liu, JC., Zacksenhaus, E., Shan, SW., Yang, BB., Dash, R., Fisher, PB., Archer, MC., and Ben-David, Y (2013). mda-7/IL-24 Expression inhibits breast cancer through upregulation of growth arrest-specific gene 3 (gas3) and disruption of β1 integrin function. Mol Cancer Res. 11:593-603. 4. Tomic, J., McCaw, L., Li, Y., Hough, MR., Ben-David, Y., Moffat, J., Spaner, DE. (2013). Resvertrol has anti-leukemic activity associated with decreased O-GLcHAcylated proteins. Exp. Hematol. 41:675-86. 5. Haeri, M., Li, Y., Li, Y., Li, Q., Spaner, DE., Ben-David, Y. (2013). Insertional activation of myb by F-MuLV in SCID mice induces myeloid leukemia. Int J Oncol. 43: 169-76. 6. Xiao X. and Ben-David Y. (2014). Erythropoietin. Encyclopedia of Immunotoxcity. DOI 10.1007/978-3-642-27786-3_466-2, Springer-Verlag Berlin Heidelberg. 7. Li, Y., Luo, H., Liu, T., Zachsenhaus, E., and Ben-David, Y. (2015) The ets transcription factor Fli-1 in development, cancer and disease. Oncogene 35: 2022-031. 8. Li, Y., Shi, Y., McCaw, L., Li,YJ., Zhu, F., Gorczynski, R., Duncan, GS., Yang, B., Ben-David, Y and Spaner, DE (2015) Micronvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A. Blood 126:766-78. 9. Menezes, ME., Shen, XN., Das, SK., Emdad, L., Guo, C., Yuan, F., Li, YJ., Archer, MC., Zacksenhaus, E., Windle, JJ., Subler, MA., Ben-David, Y., Sarkar, D., Wang, XY., Fisher, PB (2015). MDA-7/IL-24 functions as a tumor suppressor gene in vivo in transgenic mouse models of breast cancer. Oncotarget. 6:36928-42. 10. Li, YJ., Liu, G., Xia, L., Xiao, X., Liu, JC., Menezes, ME., Das, SK., Emdad, L., Sarkar, D., Fisher, PB., Archer, MC., Zacksenhaus, E., Ben-David, Y. (2015). Suppression of Her2/Neu mammary tumor development in mda-7/IL-24 transgenic mice. Oncotarget. 2015 6:36943-54. 11. Xia L, Plachynta M, Liu TJJ, Xiao X, Song JL, Li XG, Mu Z, Yao Y, Luo H, Hao XJ and Ben-David Y. (2016). Pro-inflammatory effect of a TCM formula with strong anti-cancer activity in vitro impedes tumor inhibitory potential in vivo. Molecular and Clinical Oncology, 5, 717-23. 12. Lu C, Yan X, Tu Q, Di Y, Yuan C, Fang X, Ben-David Y, Xia L, Gong J, Shen Y, Yang Z, Hao X (2016). Isolation and Asymmetric Total Synthesis of Perforanoid A. Angew Chem Int Ed Engl. 55:14373-77. 13. Dongsong T, Ping Y, Lei X, Yimin F, Wei G, Lie-Jun H, Ben-David Y, Xin X, Ying-tong D, Yuan, Chun-Mao Y, and Hao H-J (2016). Garmultins A-G, Biogenetically Related Polycyclic Acylphloroglucinols from Garcinia multiflora. Organic Letters, 18:5904-07. 14. Tan Y, Xiao X, Yao J, Han F, Lou H, Luo H, Liang G, Ben-David Y, Pan W (2016). Synthesis and Anti-cancer Activity of Glycosylated Derivatives of Diosgenin. Chemical Research in Chinese Universities. 33, 80–86. 15. Liu TJJ, Yao Y, Wang Y, Zhang G, Deng B, Jiang CY, Song JL, Li XG, Han F, Xiao X, Xia L, Li YJ, Plachynta M, Zhang M, Yan C, Mu SZ, Luo H, Zacksenhaus E, Hao XJ and Ben-David Y. (2016). A screen for Fli-1 transcriptional modulators identifies PKC agonists that induce erythroid to megakaryocytic differentiation and suppress leukemogenesis. Oncotarget. 8:16728-43. 16. Zacksenhaus E, Liu JC, Jinag Zhe, Yao Y, Lei X, Shrestha M, Ben-David Y. (2017). Transcription factors in breast cancer-lesson from recent genomic analyses and therapeutic implications. Advanced in Protein Chemistry and structural Biology. 107:223-273. 17. Vecchiarelli-Federico LM, Liu TJJ, Yao Y, Gao Y, Li Y, Li Y-J, Ben-David Y. (2017). Fli-1 overexpression in erythroleukemic cells promotes erythroid de-differentiation while Spi-1/PU.1 exerts the opposite effect. International Journal of Oncology, 2:456-66. 18. Wang S, Liu JC, YoungJun Ju YJ, Voisin V, Wang D-W, Lehal R, Ben-David Y, Bader GD and Zacksenhaus E. (2017). MicroRNA-143/145 loss induces Ras signaling to promote aggressive Pten-deficient basal-like breast cancer JCI Insight: Aug 3;2(15). 19. Xia L, Xiao X, Liu W, Song Y, Liu TJJ, Li Y-J, Zacksenhaus E, Hao H-J, Ben-David Y (2018). Coactosin-like protein CLP/Cotl1 inhibits breast cancer through activation of IL-24/PERP pathway and suppression of non-canonical TGFβ signaling. Oncogene, doi:10.1038/onc.2017.342 (IF 7.5)