Goulian, Mark - The University of Pennsylvania

个人简介

Ph.D., Harvard University, 1990

研究领域

Our lab is broadly interested in the mechanisms that bacteria employ to adapt to changes in their environment. Most of our efforts have focused on the biochemical circuits that enable Escherichia coli and related bacteria to sense and respond to intra- and extracellular signals. We are especially interested in how these circuits evolve and how they interact with other pathways in the cell. Current research interests include antimicrobial peptide resistance, adaptation to changes in oxygen availability, and commensal colonization of the gastrointestinal tract.

近期论文

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Encoding biological recognition in a bicomponent cell-membrane mimic.Rodriguez-Emmenegger C, Xiao Q, Kostina NY, Sherman SE, Rahimi K, Partridge BE, Li S, Sahoo D, Reveron Perez AM, Buzzacchera I, Han H, Kerzner M, Malhotra I, Möller M, Wilson CJ, Good MC, Goulian M, Baumgart T, Klein ML, Percec V.Proc Natl Acad Sci U S A. 2019 Feb 28. pii: 201821924. doi: 10.1073/pnas.1821924116. [Epub ahead of print] Bioactive cell-like hybrids from dendrimersomes with a human cell membrane and its components.Yadavalli SS, Xiao Q, Sherman SE, Hasley WD, Klein ML, Goulian M, Percec V.Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):744-752. doi: 10.1073/pnas.1811307116. Epub 2018 Dec 27. Regulated Stochasticity in a Bacterial Signaling Network Permits Tolerance to a Rapid Environmental Change.Carey JN, Mettert EL, Roggiani M, Myers KS, Kiley PJ, Goulian M.Cell. 2018 Dec 13;175(7):1989-1990. doi: 10.1016/j.cell.2018.11.051. No abstract available. The SOS Response Mediates Sustained Colonization of the Mammalian Gut.Samuels AN, Roggiani M, Zhu J, Goulian M, Kohli RM.Infect Immun. 2018 Dec 3. pii: IAI.00711-18. doi: 10.1128/IAI.00711-18. [Epub ahead of print] The Phosphohistidine Phosphatase SixA Targets a Phosphotransferase System.Schulte JE, Goulian M.MBio. 2018 Nov 27;9(6). pii: e01666-18. doi: 10.1128/mBio.01666-18. A bacterial signaling system regulates noise to enable bet hedging.Carey JN, Goulian M.Curr Genet. 2019 Feb;65(1):65-70. doi: 10.1007/s00294-018-0856-2. Epub 2018 Jun 12. Review. Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network.Culyba MJ, Kubiak JM, Mo CY, Goulian M, Kohli RM.PLoS Genet. 2018 Jun 1;14(6):e1007405. doi: 10.1371/journal.pgen.1007405. eCollection 2018 Jun. Microbes vs. chemistry in the origin of the anaerobic gut lumen.Friedman ES, Bittinger K, Esipova TV, Hou L, Chau L, Jiang J, Mesaros C, Lund PJ, Liang X, FitzGerald GA, Goulian M, Lee D, Garcia BA, Blair IA, Vinogradov SA, Wu GD.Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4170-4175. doi: 10.1073/pnas.1718635115. Epub 2018 Apr 2. Regulated Stochasticity in a Bacterial Signaling Network Permits Tolerance to a Rapid Environmental Change.Carey JN, Mettert EL, Roggiani M, Myers KS, Kiley PJ, Goulian M.Cell. 2018 Mar 22;173(1):196-207.e14. doi: 10.1016/j.cell.2018.02.005. Epub 2018 Mar 1. Erratum in: Cell. 2018 Dec 13;175(7):1989-1990. A network of regulators promotes dehydration tolerance in Escherichia coli.Chen AI, Goulian M.Environ Microbiol. 2018 Mar;20(3):1283-1295. doi: 10.1111/1462-2920.14074. Epub 2018 Mar 14. Films of Bacteria at Interfaces (FBI): Remodeling of Fluid Interfaces by Pseudomonas aeruginosa.Niepa THR, Vaccari L, Leheny RL, Goulian M, Lee D, Stebe KJ.Sci Rep. 2017 Dec 19;7(1):17864. doi: 10.1038/s41598-017-17721-3. A role for bacterial urease in gut dysbiosis and Crohn's disease.Ni J, Shen TD, Chen EZ, Bittinger K, Bailey A, Roggiani M, Sirota-Madi A, Friedman ES, Chau L, Lin A, Nissim I, Scott J, Lauder A, Hoffmann C, Rivas G, Albenberg L, Baldassano RN, Braun J, Xavier RJ, Clish CB, Yudkoff M, Li H, Goulian M, Bushman FD, Lewis JD, Wu GD.Sci Transl Med. 2017 Nov 15;9(416). pii: eaah6888. doi: 10.1126/scitranslmed.aah6888. Natural variation of a sensor kinase controlling a conserved stress response pathway in Escherichia coli.Roggiani M, Yadavalli SS, Goulian M.PLoS Genet. 2017 Nov 15;13(11):e1007101. doi: 10.1371/journal.pgen.1007101. eCollection 2017 Nov. A Small-Molecule Inducible Synthetic Circuit for Control of the SOS Gene Network without DNA Damage.Kubiak JM, Culyba MJ, Liu MY, Mo CY, Goulian M, Kohli RM.ACS Synth Biol. 2017 Nov 17;6(11):2067-2076. doi: 10.1021/acssynbio.7b00108. Epub 2017 Sep 1. Self-interrupted synthesis of sterically hindered aliphatic polyamide dendrimers.Jishkariani D, MacDermaid CM, Timsina YN, Grama S, Gillani SS, Divar M, Yadavalli SS, Moussodia RO, Leowanawat P, Berrios Camacho AM, Walter R, Goulian M, Klein ML, Percec V.Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2275-E2284. doi: 10.1073/pnas.1700922114. Epub 2017 Mar 7. Corrigendum: Microbial Nanoculture as an Artificial Microniche.Niepa TH, Hou L, Jiang H, Goulian M, Koo H, Stebe KJ, Lee D.Sci Rep. 2017 Feb 22;7:42568. doi: 10.1038/srep42568. No abstract available. Self-Sorting and Coassembly of Fluorinated, Hydrogenated, and Hybrid Janus Dendrimers into Dendrimersomes.Xiao Q, Rubien JD, Wang Z, Reed EH, Hammer DA, Sahoo D, Heiney PA, Yadavalli SS, Goulian M, Wilner SE, Baumgart T, Vinogradov SA, Klein ML, Percec V.J Am Chem Soc. 2016 Sep 28;138(38):12655-63. doi: 10.1021/jacs.6b08069. Epub 2016 Sep 14. Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics.Mo CY, Manning SA, Roggiani M, Culyba MJ, Samuels AN, Sniegowski PD, Goulian M, Kohli RM.mSphere. 2016 Aug 10;1(4). pii: e00163-16. doi: 10.1128/mSphere.00163-16. eCollection 2016 Jul-Aug. Microbial Nanoculture as an Artificial Microniche.Niepa TH, Hou L, Jiang H, Goulian M, Koo H, Stebe KJ, Lee D.Sci Rep. 2016 Aug 1;6:30578. doi: 10.1038/srep30578. Erratum in: Sci Rep. 2017 Feb 22;7:42568. Antimicrobial peptides trigger a division block in Escherichia coli through stimulation of a signalling system.Yadavalli SS, Carey JN, Leibman RS, Chen AI, Stern AM, Roggiani M, Lippa AM, Goulian M.Nat Commun. 2016 Jul 29;7:12340. doi: 10.1038/ncomms12340.