Skromne, ‌Isaac - University of Miami

个人简介

Assistant Professor, 2008-present, Biology Department, The University of Miami Research Professional, 2005-2007, The University of Chicago, Chicago, IL, USA Postdoctoral Scholar, 2003-2005, The University of Chicago, Chicago, IL, USA Postdoctoral Fellow, 2001-2003, The University of Chicago, Chicago, IL, USA Visiting Research Fellow, 2000-2001, Princeton University, Princeton, NJ, USA Embryology Fellow, 2000, Marine Biological Laboratory, Woods Hole, MA, USA Ph.D. with Honors, 2000, Columbia University, New York, NY, USA M. Phil., 1996, Columbia University, New York, NY, USA M.S., 1995, Columbia University, New York, NY, USA B.S. with Distinction, 1994, National Autonomous University of Mexico, Mexico City, Mexico

研究领域

My group is interested in how two fundamental developmental processes, segmentation and patterning, are regulated and coordinated during vertebrate embryogenesis to generate morphological complexity. While segmentation subdivides the embryonic body plan into an array of morphologically similar units or segments, patterning processes assign different positional identities to such units based on their anterior-posterior position along the main body axis of the embryo. What are the mechanisms that coordinate segmentation and patterning within and between different tissues such as the nervous system and mesoderm (muscle and bone forming tissue)? What are the conserved and divergent aspects of this machinery that drive variation in segment number and/or identity between vertebrates? We are addressing these questions using the chicken and zebrafish embryos as model organisms. This allows us to combine classic embryological techniques with powerful molecular and genetic approaches. By using two evolutionarily distant organisms, we expect not only to elucidate the core molecular processes underlying segmentation and patterning of the nervous system and mesoderm, but also the source of diversity in vertebrate segment number and form. Furthermore, we expect this research to have important medical implications as it directly addresses developmental processes underlying common birth defects such as open neural tube or congenital vertebral malsegmentation.

近期论文

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Cheng, J., Skromne, I., and Ho. R. K. (2016) Cdx4 and Retinoic Acid interact to position the hindbrain-spinal cord transition. Developmental Biology. 410:178-189. Hayward, A. G., Joshi, P., and Skromne, I. (2015) Spatiotemporal analysis of zebrafish hox gene regulation by Cdx4. Developmental Dynamics 244:1564-1573. Lee, K. and Skromne, I. (2014) Retinoic acid regulates, size, pattern and alignment of tissues at the head-trunk transition. Development 141:4375-4384. Yariz, K. O., Duman, D., Seco, C. Z., Dallman, J., Huang, M. Peters, T. A., Sirmaci, A., Lu, N., Schraders, M., Skromne, I., and ten others (2012) Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss. Am. J. Human. Genet. 91, 872-882. Skromne, I., Thorsen, D., Hale, M., Prince, V. E. and Ho, R. K. (2007) Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord.Development 134, 2147-2158. Foley, A. C., Skromne, I. and Stern, C. D. (2000) Reconciling different models of forebrain induction and patterning: a dual role for the hypoblast. Development 127, 3839-3854.