Lu, Zhongmin - University of Miami - Department of Biology

个人简介

2005 - present Associate Professor, Department of Biology, University of Miami 2012-present, Visiting Research Fellow, International Center for Marine Studies, Shanghai Ocean University, The People’s Republic of China (PRC) 2006, Neural Development and Genetics in Zebrafish course with Certificate, Marine Biological Laboratory, Woods Hole2002 - pesent, Faculty, The Neuroscience Program, University of Miami School of Medicine 2000 - present, Investigator, NIEHS Marine and Freshwater Biomedical Sciences Center (MFBSC), Rosenstiel School of Marine & Atmospheric Science (RSMAS), University of Miami 1999 - 2005, Assistant Professor, Department of Biology, University of Miami 1998 - 1999, Research Assistant Professor, Department of Biology, University of Maryland, College Park 1997 - 1998, Assistant Research Scientist, Department of Biology, University of Maryland, College Park Postdoctoral work in Neuroscience, University of Maryland, College Park, 1995 - 1999 1995, Ph.D. Experimental Psychology, Loyola University Chicago 1993, M.A. Experimental Psychology, Loyola University Chicago 1988, M.S. Neurophysiology, Yunnan University, Kunming, The People’s Republic of China (PRC) 1985, B.S. Biology, Capital Normal University, Beijing, PRC

研究领域

I am interested in sensory neurobiology with the primary focus on the sense of hearing. My Previous work emphasized on central auditory processing, sound localization, and ultrasonic detection in fish. The current research of my lab is to use the zebrafish (Danio rerio) to model hearing disorders in humans. The zebrafish has become an increasingly important vertebrate model for biomedical research because it combines powerful genetics, excellent embryology, and exceptional in vivo visualization in one organism. In addition to hair cells in the inner ear, zebrafish have hair cells in lateral line neuromasts on the surface of the body, making them easily accessible for live imaging and experimental manipulation. Particularly, my lab is conducting experiments on zebrafish to understand biological mechanisms underlying human hearing loss and fetal alcohol syndrome using multiple approaches, including behavioral, developmental, confocal and electron microscopic, electrophysiological, morpholino gene knockdown, and molecular techniques.

近期论文

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Diaz-Horta, O., Subasioglu-Uzak, A., Grati, M., DeSmidt, D. A., Foster II, J., Cao, L., Tokgoz-Yilmaz, S., Duman, D., Cengiz, F. B., Abad, C., Mittal, R., Blanton, S. H., Liu, X. Z., Farooq, A., Walz, K., Lu, Z. and Tekin, M. (2014) FAM65B is a membrane-associated protein of hair cell stereocilia required for hearing. The Proceedings of the National Academy of Sciences USA 111: 9864-9868. Lu, Z. and DeSmidt A. A. (2013) Early development of hearing in zebrafish. Journal of the Association for Research in Otolaryngology (JARO) 14: 509-521. Zamora, L. and Lu, Z. (2013) Alcohol-induced morphological deficits in the development of octavolateral organs of the zebrafish (Danio rerio). Zebrafish 10: 52-61. Yariz, K., Duman, D., Seco, C. Z., Dallman, J., Huang, M., Peters, T., Sirmaci, A., Lu, N., Schraders, M., Skromne, I., Oostrik, J., Tokgoz-Yilmaz, S., Konukseven, O., Shahin, H., Kanaan, M., Edwards, Y. J. K., Li, H., Atalay, S., Blanton, S., DeSmidt, A. A., Liu, X. Z., Pennings, R., Lu, Z., Chen, Z. Y., Kremer, H. and Tekin, M. (2012) Mutations in OTOGL, encoding otogelin-like, cause moderate sensorineural hearing loss. American Journal of Human Genetics 91: 872-882. Lu, Z., Xu, Z. and Buchser, W. J. (2010) Frequency coding of particle motion by saccular afferents of a teleost fish. Journal of Experimental Biology 213: 1591-1601. Tomchik, S. M. and Lu, Z. (2005) Central octavolateral projections and convergence in the medulla of a teleost fish, the sleeper goby (Dormitator latifrons). Journal of Comparative Neurology 481: 96-117