Dallman, Julia - University of Miami

个人简介

2016-Present, Associate Professor, University of Miami, Department of Biology 2010, Director of University of Miami Zebrafish Facility 2007-2016, Assistant Professor, Univeristy of Miami, Department of Biology 2005, Co-lecturer Comparative Invertebrate Embryology(Zool. 536) Friday Harbor Laboratories, University of Washington 2003-2007, Research Assistant Professor, Dept. of Neurobiology, SUNY Stony Brook, NY Mentor: Dr. Paul Brehm 1998-2003, Postdoctoral Fellow, Dept. of Neurobiology, SUNY Stony Brook, NY Mentor: Dr. Gail Mandel 1991-1998, Ph.D. from the Dept of Zoology, University of Washington, Seattle, WA Mentor: Dr. William J Moody 1987-1991, BA from the Dept. of Biology, Swarthmore College, Swarthmore, PA

研究领域

Determining the mechanisms by which genes influence behavior is the central goal of my research program. The genome-sequencing revolution has identified thousands of genetic mutations that cause neurological disorders that impact human behavior. For any given disorder, mutations in hundreds of different genes can similarly affect behavior, and yet how these disparate mutations converge on similar behavioral phenotypes is largely unknown. To address this question, my group generates zebrafish models of inherited human behavioral disorders to understand how mutations impact neural circuit development and behavior. By comparing multiple forms of a single disorder, we elucidate shared mechanisms by which different mutations affect behavior. Our long-term goal is to leverage these models to inform treatment strategies for individuals with inherited disorders of the nervous system.

近期论文

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Kozol RA, Abrams AJ, James DM, Buglo E, Yan Q, Dallman JE. Function Over Form: Modeling Groups of Inherited Neurological Conditions in Zebrafish. Frontiers in Molecular Neuroscience 2016.00055:Research Topic: Molecular, cellular and model organism approaches for understanding the basis of neurological disease. Rebelo AP, Abrams AJ, Cottenie E, Horga A, Gonzalez M, Bis DM, Sanchez-Mejias A, Pinto M, Buglo E, Markel K, Prince J, Laura M, Houlden H, Blake J, Woodward C, Sweeney MG, Holton JL, Hanna M, Dallman JE, Auer-Grumbach M, Reilly MM, Zuchner S. (2016) Cryptic Amyloidogenic Elements in the 3' UTRs of Neurofilament Genes Trigger Axonal Neuropathy. Am J Hum Genet 98(4):597-614. Li S, Peng Z, Dallman J, Baker J, Othman AM, Blackwelder PL, Leblanc RM. (2016) Crossing the blood–brain–barrier with transferrin conjugated carbon dots: A zebrafish model study. Colloids and Surfaces B: Biointerfaces 145, 251-256. Koenighofer M, Hung CY, McCauley JL, Dallman JE, Back EJ, Mihalek I, Gripp KW, Sol-Church K, Rusconi P, Zhang Z, Shi G, Andres DA and Bodamer OA. (2016) Mutations in RIT1 cause Noonan syndrome – additional functional evidence and expanding clinical phenotype. Clinical Genetics 89(3):359-366. Abrams AJ, Hufnagel RB, Rebelo A, Zanna C, Patel N, Gonzalez M, Campeanu J, Griffin L, Groenewald S, Strickland A, Tao F, Speziani F, Caporali L, Ahmed ZM, Sund KL, Wang X, Krueger LA, Peng Y, Prada CE, Prows CA, Bove K, Schorry EK, Antonellis A, Zimmerman HH, Abdulrahman OA, Yang Y, Downes S, Prince J, Nemeth A, Carelli V, Huang T, Züchner S, Dallman JE. (2015) Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder. Nature Genetics 47(8): 928. Kozol RA, Cukier HN, Mayo V, Griswald AJ, Whitehead PL, Haines JL, Gilbert JR, Cuccaro ML, Martin ER, Baker JD, Buxbaum JD, Pericak-Vance MA, Dallman JE. (2015) Two zebrafish autism models of SYNGAP1 and SHANK3 knock-down produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis. Human Molecular Genetics 24(14):4006-23. Wen R, Dallman JE, Li Y, Züchner S, Vance JM, Peričak-Vance MA, Lam BL. (2014) Knock-Down DHDDS Expression Induces Photoreceptor Degeneration in Zebrafish. Advances in Experimental Medicine and Biology. 801:543-50. Ganser LR, Yan Q, James VM, Kozol R, Topf M, Harvey RJ, and Dallman JE. (2013) Distinct phenotypes in zebrafish models of human startle disease. Neurobiology of Disease 60:139-51. Wen H, Linhoff M, Hubbard J, Nelson N, Stensland D, Dallman JE, Mandel G, and Brehm P. (2013) Zebrafish calls for reinterpretation for the roles of P/Q calcium channels in neuromuscular transmission. Journal of Neuroscience 33(17): 7384-92.