Baker, James - University of Miami - Department of Biology

个人简介

2007-present, Research Assistant Professor, and Imaging Core Facility Manger, University of Miami Biology Department 2002-2007, Research associate, Stony Brook University 1998-2002, Postdoctoral fellow with M. Kernan, Stony Brook University, 1990-1998, Ph.D.Graduate student with J.W. Truman, University of Washington, 1986-1990, University of Iowa, Undergraduate research assistant

研究领域

I study the mechanisms that regulate and underlie ciliary development in animals (Drosophila in particular). While cilia are ubiquitous on animal cells and intriguing for their fantastic ultrastructure, they have only recently been recognized as having fundamental roles in development and human disease. In my lab we seek to understand one of the earliest steps in cilia formation, how the centrioles, a component of the microtubule-nucleating centrosome, are respecified to initiate cilia formation. Recently I have been pursuing the function of kokopelli, a novel cyclin isolated using a yeast 2-hybrid protein interaction screen for proteins involved in altering centrioles to produce ciliogenic basal bodies.

近期论文

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Price DR, Feng H, Baker JD, Bavan S, Luetje CW, Wilson AC. (2014) Aphid amino acid transporter regulates glutamine supply to intracellular bacterial symbionts. Proc Natl Acad Sci. 111(1):320-5. doi: 10.1073. Keroles, MB, Dusseault, SK, Liu, C, Mohammed, MR, Vandakkan, Christy M., Amiel, Jessica H., Abel, SN, Bensoussan, ER, Russell, BL, Baker, JD. (2013) Imaging Through the Pupal Case of Drosophila melanogaster JoVE doi:10.3791/51239. Ragab SS, Swaminathan S, Baker JD, Raymo FM. (2013) Activation of BODIPY fluorescence by the photoinduced dealkylation of a pyridinium quencher. Phys Chem Chem Phys. 15(36):14851-5. doi:10.1039/c3cp51580j. Pitter DR, Wigenius J, Brown AS, Baker JD, Westerlund F, Wilson JN. (2013) Turn-on, fluorescent nuclear stains with live cell compatibility. Org Lett. 15(6):1330-3. Boulina M, Samarajeewa H, Baker JD, Kim MD, Chiba A. (2013) Live imaging of multicolor-labeled cells in Drosophila. Development 140(7):1605-13 Swaminathan, S., Petriella, M., Deniz, E., Cusido, J., Baker, J.D., Bossi, M.L., Raymo, F.M. (2012) Fluorescence photoactivation by intermolecular proton transfer. J. Phys. Chem. A. 116(40):9928-33. Baker, J.D., Adhikarakunnathu, S.D., and Kernan, M. (2004).Mechanosensory-defective, male-sterile unc mutants identify a novel basal body protein required for ciliogenesis in Drosophila. Development 131:3411-3422.