Nesnas, Nasri - Florida Institute of Technology

个人简介

B.S. Manhattan college 1994 M.A. Columbia University 1995 M.Phil. Columbia University 1998 Ph.D. Columbia University 1999 Professor of Chemistry, Florida Institute of Technology, 2017-Present Visiting Guest Professor (Sabbatical Research), California Institute of Technology, 2014-2015 Associate Professor of Chemistry, Florida Institute of Technology, 2008-2017 Assistant Professor of Chemistry, Florida Institute of Technology, 2002-2008 Postdoctoral Fellow, Columbia University 1999-2002

研究领域

CURRENT RESEARCH AREAS (last updated September 2015) 1) Developing novel types of neurotransmitters 2) The Chemistry of Vision and light absorbing molecules 3) Catalysis of organic reactions 4) Cyclodextrins in food and drug delivery 5) Isolation and characterization of biologically active molecules 6) Using Mass Spec in unusual ways Nature is the single-best and most-omniscient source of information with which we can all be in touch. An improvement of our understanding of basic phenomena is a mere development of the medium by which we interact with nature. Chemistry, one such medium, offers a wide variety of techniques through which we can essentially observe natural phenomena and thus learn firsthand lessons from nature. We are interested in applying these lessons in the development of novel structures that have the ability to carry out a function of interest. Enzyme catalysis, which remains superior to any single organic reaction, in both rate and specificity, is the result of eons of irrational adaptation and evolution directed at achieving such a function. With modern tools, such as X-ray analysis, scientists have been able to 'view' the intricate details that such an adaptation has evolved into. Biomimetic chemists take the many years of evolution and introduce them into a novel and rationally designed system that, in effect, mimics what nature strives to achieve. While nature has had billions of trials and errors over billions of years, we compete with several trials over perhaps several years, and still do well enough to achieve moderate rates and often quite decent selectivities. In one of our projects, we will combine the power of evolution along with human rational design in optimizing a receptor for a biologically active structure, via the irrational combinatorial approach of catalytic antibodies, and the rational design of an intricate catalytic moiety to perform the function of interest. For instance, cocaine addiction remains one of the most elusive dilemmas in drug therapy. This is because antagonists simply bind to the same dopamine transporter that cocaine binds to, thus rendering similar detrimental effects. A better and more promising approach will endeavor to chemically destroy cocaine via catalytic hydrolysis of one of its ester bonds. Therefore, cocaine will present an ideal candidate for the design of our catalytic system. We are also interested in designing new catalytic reactions and applying them to the total synthesis of natural products. We are currently carrying out the synthesis of the skeleton of an anticancer drug. Further modification of the side chains of these drugs will lead to optimized biological activity which will ultimately enhance their potential as therapeutic drugs. One of the most fascinating and highly efficient systems in nature is vision. The high efficiency derives from the single photon of light that is sufficient in activating a thousand G-proteins, which in turn result in the hydrolysis of around 100,000 cGMP to GMP, ultimately leading to a neuronal signal. A study of these proteins through the design and synthesis of various visual chromophores will slowly unravel this intriguing design, eventually leading us in the direction of the design of similar systems geared to current needs, including therapeutic treatments.

近期论文

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Comitz, Richard L.; Youedraogo, Yannick P.; Nesnas, Nasri Anal. Chem. Res. 2015, 3, 20-25. Youedraogo, Yannick P.; Huang, Longchuan; Torrente, Mariana P.; Proni, Gloria; Chadwich, Ekaterina; Wehmschulte, Rudolf J.; Nesnas, Nasri Chirality 2013, 25, 575-581. Sharma, Virender K.; Sohn, Mary; Anquandah, George A. K.; Nesnas, Nasri Chemosphere 2012, 87(6), 644-648 (pdf) Kpegba, Kafui; Agbonon, Amegnona; Petrovic, Ana G.; Amouzou, Etchri; Gbeassor, Messanvi; Proni, Gloria; Nesnas, Nasri J. Nat. Prod. 2011, 74(3), 455-459 (pdf) Sharma, V. K.; Anquandah, G.;Nesnas, N. Kinetics of the Oxidation of Endocrine Disruptor Nonylphenol by Ferrate(VI) Environ. Chem. Lett. 2009, 7, 115-119.(pdf) Sharma, Virender K.; Noorhasan, Nadine N.; Mishra, Santosh K.; Nesnas, Nasri. Ferrate(VI) oxidation of reclacitrant compounds: removal of biological resistant organic molecules by ferrate(VI). ACS Symposium Series (Ferrates) 2008, 985, 339-349.(pdf) Kpegba, K.; Spadaro, T.; Cody, R. B.; Nesnas, N.; Olson, J. A. "Analysis of Self-Assembled Monolayers on Gold Surfaces Using Direct Analysis in Real Time Mass Spectrometry;" Anal. Chem. 2007, 79(14), 5479-5483.(pdf) Matsuda, H.; Zhang, S.; Holmes, A. E.; Krane, S.; Itagaki, Y.; Nakanishi, K.; Nesnas, N. "Synthesis of an 11-cis-locked biotinylated retinoid for sequestering 11-cis-retinoid binding proteins;" Can. J. Chem. 2006, 84(10), 1363-1370. (pdf) Tewari, B. B.; Shekar, S.; Huang, L.; Gorrell, C. E.; Murphy, T. P.; Warren, K.; Nesnas, N.; Wehmschulte, R. J. "Aluminumoxyhydride: Improved Synthesis and Application as a Selective Reducing Agent;" Inorg. Chem. 2006, 45 (21), 8807-8811. (pdf) Sharma, V. K.; Mishra, S. K.; Nesnas, N. "Oxidation of Sulfonamide Antimicrobials by Ferrate(VI) [FeVIO42-];" Environ. Sci. & Technol. 2006, 40 (23), 7222-7227 (pdf) Kpegba, K.; Murtha, M.; Nesnas, N. "Cyclodextrin retinylidene: A biomimetic kinetic trap model for rhodopsin;" Bioorg. Med. Chem. Lett. 2006, 16 (6), 1523-1526. (pdf Jahng, W. J.; David, C.; Nesnas, N.; Nakanishi, K.; Rando, R. R. “A Cleavable Affinity Biotinylating Agent Reveals a Retinoid Binding Role for RPE65;” Biochemistry 2003, 42 (20), 6159-6168. (pdf) Zemelman, B. V.; Nesnas, N.; Lee, G. A.; Miesenböck, G. "Photochemical Gating of Heterologous Ion Channel: Remote Control over Genetically Designated Populations of Neurons;" Proc. Nat. Acad, Sci. USA 2003, 100 (3), 1352-1357. (pdf) Nesnas, N.; Rando, R.; Nakanishi, K. “Synthesis of Biotinylated Retinoids for Cross-Linking and Isolation of Retinol Binding Proteins;” Tetrahedron 2002, 58, 6577-6584. (pdf) Kurtán, T.; Nesnas, N.; Li, Y.-Q.; Huang, X.; Nakanishi, K.; Berova, N. “Chiral Recognition by CD-Sensitive Dimeric Zinc Porphyrin Host. 1. Chiroptical Protocol for Absolute Configurational Assignments of Monoalcohols and Primary Monoamines;” J. Am. Chem. Soc. 2001, 123, 5962-5973. (pdf) Kurtán, T.; Nesnas, N.; Koehn, F. E.; Li, Y.-Q.; Nakanishi, K.; Berova, N. “Chiral Recognition by CD-Sensitive Dimeric Zinc Porphyrin Host. 2. Structural Studies of Host-Guest Complexes with Chiral Alcohol and Monoamine Conjugates;” J. Am. Chem. Soc. 2001, 123, 5974-5982.(pdf) Nesnas, N.; Lou, J.; Breslow, R. “The Binding of Cocaine to Cyclodextrins;” Bioorg. Med. Chem. Lett. 2000, 10, 1931-1933. (pdf) Breslow, R.; Nesnas, N. “Burst Kinetics and Turnover in an Esterase Mimic;” Tetrahedron Lett. 1999, 40, 3335-3338. (pdf)