个人简介

B.A. Middlebury College 1979 Ph.D. University of Wisconsin, Madison 1986 Dr. Brown was a National Institutes of Health postdoctoral fellow at Columbia University from 1986 to 1988, and came to Florida Tech in 1988.

研究领域

Dr. Brown’s research is in structural physical-organic chemistry. He is interested in the structural bases of chemical phenomena such as aromaticity, molecular recognition and molecular sensing. His group designs molecules that test various structural ideas, makes the molecules and tests the hypotheses experimentally and theoretically.

In collaboration with Dr. Baum, Dr. Brown is constructing molecules containing a carbazole ring (carbazoles fluoresce) and a quencher (acridine or pyridine), in mutual orientations that favor intramolecular hydrogen bonding. The presence of hydrazines or primary amines "turns on" the fluorescence of these molecules, allowing highly sensitive sensing of hydrazines and primary amines. (NASA) In collaboration with Paul Kiprof (University of Minnesota, Duluth), Dr. Brown is carrying out extensive theoretical studies of annulated benzenes and Dewar benzenes. (Petroleum Research Fund) Two new programs concern NMR analysis of nitrogen heterocycles, in collaboration with Ashraf Aly (El-Minia University, Egypt) and Scott McKay (Southern Arkansas University). Unconventional applications of NMR spectroscopy include whole-organism studies of live fish, in collaboration with Jon Shenker (Department of Biological Sciences).

近期论文

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Elkanzi, N.A.A., N.M. Morsy, A.A. Aly, A.B. Brown, and M. Ramadan, 2016. New pyrimidine-2-thiones from reactions of amidrazonethiols with 2-amino-1,1,2-ethenetricarbonitrile and investigation of their antitumor activity. Journal of Heterocyclic Chemistry 53:1838-1842. Aly, A.A., M. Ramadan, M. Abd Al-Aziz, H.M. Fathy, S. Bräse, A.B. Brown, and M. Nieger, 2016. Reaction of amidrazones with 2,3-diphenylcyclopropenone: synthesis of 3-(aryl)-2,5,6-triphenylpyrimidin-4(3H)-ones. Journal of Chemical Research 40:637-639. Aly, A.A., T. El Malah, E.A. Ishak, A.B. Brown, and W.M. Elayat, 2016. Tetracyanoethene and 1-amino-1,2,2-ethenetricarbonitrile in the synthesis of heterocycles of potential antioxidant and antibacterial activities. Journal of Heterocyclic Chemistry 53:963-969. El Malah, T., A.A. Aly, S. Bräse, N.A.A. Elkanzi, and A.B. Brown, 2016. Reaction of dithiocarbamates with 2-[bis(methylthio)-methylene]malononitrile: unexpected formation of 4-imino-6-(methylthio)-3-substituted-3,4-dihydro-2H-1,3-thiazine-2-thiones. Journal of Sulfur Chemistry 37:222-228. Aly, A.A., E.A. Ishak, T. El Malah, A.B. Brown, and W.M. Elayat, 2015. Synthesis of potentially antioxidant and antibacterial biologically active thiazolidines. Journal of Heterocyclic Chemistry 52:1758-1764. Aly, A.A., A.B. Brown, A.A. Hassan, M.A.-M. Gomaa, and F.M. Nemr, 2015. Reaction of ethyl 2-cyano-3,3-bis(methylthio)acrylate with amidrazones: synthesis of new mercapto pyrazoles and NMR investigation. Journal of Sulfur Chemistry 36:502-510. Hassan, A.A., A.A. Aly, K.M.A. El-Shaieb, T.M.I. Bedair, S. Bräse, and A.B. Brown, 2014. Synthesis of thiazolidin-4-ones from substituted (ylidene)hydrazinecarbothioamides and dimethyl acetylenedicarboxylate. Journal of Heterocyclic Chemistry 51:674-682. Hassan, A.A., Y.R. Ibrahim, A.A. Aly, E.M. El-Sheref, and A.B. Brown, 2014. Synthesis of N-substituted(thiazol-2-ylidene)-pyrazol-5-amine derivatives via condensation of pyrazolylthioureas with w-bromoacetophenones. Journal of Heterocyclic Chemistry 51:610-617. Aly, A.A., A.B. Brown, and A.A. Hassan. 2014. Heterocycles from the reaction of thione groups with acetylenic bonds. Advances in Heterocyclic Chemistry 113:245-304. Aly, A.A., E.A. Ishak, and A.B. Brown. 2014. Reaction of arylidenehydrazono-4-aryl-2,3-dihydrothiazole-5-carbonitriles with diethyl acetylenedicarboxylate. Synthesis of (Z)-ethyl 2-[((Z)-2-(E)-arylidenehydrazono))-4-oxothiazolidine-5-ylidene]acetates. NMR investigation. Journal of Sulfur Chemistry 35:382-393. Aly, A.A., N.A.A. Elkanzi, and A.B. Brown. 2014. Mini review of sulfur heterocyclization from pi-deficient quinones via charge-transfer interaction. Phosphorus, Sulfur, Silicon, and the Related Elements 189:440-452. Hassan, A.A., A.A. Aly, T.I.M. Bedair, A.B. Brown, and T.I. El-Emary. 2014. A facile method for the synthesis of hydrazine-4-oxothiazolidine and imino-5-oxothiadiazine derivatives from 1,4-disubstituted thiosemicarbazides. Journal of Heterocyclic Chemistry 51:44-49. Hassan, A.A., Y.R. Ibrahim, E.M. El-Sheref, A.A. Aly, S. Bräse, and A.B. Brown. 2012. Novel synthesis of pyrazolyloxothiazolidine derivatives. Journal of Heterocyclic Chemistry 49:1380-1385. Hassan, A.A., Y.R. Ibrahim, E.M. El-Sheref, and A.B. Brown. 2012. Novel synthesis of oxothiazolidine derivatives. Journal of Heterocyclic Chemistry 49:1054-1058. Aly, A.A., A.B. Brown, T.M.I. Bedair, and E.A.-R. Ishak. 2012. Dithiocarbamate salts: their biological activity, preparation, and utility in organic synthesis. Journal of Sulfur Chemistry 33:605-617. Aly, A.A., A.B. Brown, M. Abdel-Aziz, G.E.A.A. Abuo-Rahma, M.F. Radwan, M. Ramadan, and A.M. Gamal-Eldeen. 2012. An efficient synthesis of thiazolidin-4-ones with antitumor and antioxidant activities. Journal of Heterocyclic Chemistry 49:726-731. Aly, A.A., A.A. Hassan, A.B. Brown, K.M. El-Shaieb, and T.M. Bedair. 2011. Facile synthesis of new imidazoles from direct reaction of 2,3-diamino-1,4-naphthoquinone with aldehydes. Journal of Heterocyclic Chemistry 48:787-791. Aly, A.A., A.B. Brown, M. Abdel-Aziz, G.E.A.A. Abuo-Rahma, M.F. Radwan, M. Ramadan, and A.M. Gamnal-Eldeen. 2010. New synthesis of 4-oxo-thiazolidine-5-ylidenes of antitumor and antioxidant activities. Journal of Heterocyclic Chemistry 47:547-554. Aly, A.A., A.B. Brown, M. Ramadan, M. Abdel-Aziz, G.E.A.A. Abuo-Rahma, M.F. Radwan, and A.M. Gamal-Eldeen. 2010. Selectivity of N-aroyl-N'-arylthioureas towards 2-[1,3-dioxo-1H-inden-2(3H)-ylidene]malononitrile. New synthesis of (Z)-N-{(E)-amino-1-aryl-5-cyano-6-oxo-1H-indeno[1,2-d][1,3]thioazepin-2(6H)-ylidene}4-arylamides of antitumor and antioxidant activities. Journal of Heterocyclic Chemistry 47:503-508. Aly, A.A., A.B. Brown, M. Ramadan, A.M. Gamal-Eldeen, M. Abdel-Aziz, G.E.A.A. Abuo-Rahma, and M.F. Radwan. 2010. Thieno[2,3-d]pyrimidines in the synthesis of antitumor and antioxidant agents. Archiv der Pharmazie 343:301-309. Aly, A.A., and A.B. Brown. 2009. Asymmetric and fused heterocycles based on [2.2]paracyclophane. Tetrahedron 65:8055-8089. McKay, S.E., R.W. Lashlee III, L.W. Maina, K.A. Wheeler, and A.B. Brown. 2009. Synthesis of bipyridine N-oxides and bipyridine N,N'-dioxides. Heterocyclic Communications 15:181-188. Aly, A.A., A.B. Brown, T.I. El-Emary, A.M.M. Ewas, and M. Ramadan. 2009. Hydrazinecarbothioamide group in the synthesis of heterocycles. Arkivoc (i)150-197. Aly, A.A., A.B. Brown, K.M. El-Shaieb, A.A. Hassan, and T.M.I. Bedair. 2009. NMR study of the naphtho-1,3-dithioles formed from carbamodithioates and 2,3-dichloro-1,4-naphthoquinone. Journal of Chemical Research 689-691.