个人简介

Bachelor of Science University of Miami 1991 Master of Science Rosenstiel School of Marine & Atmospheric Sciences, University of Miami 1994 Doctor of Philosophy Miller School of Medicine, University of Miami 2001 Postdoctoral Fellowships - Univ of Miami Medical School, Rosenstiel School of Marine & Atmospheric Science, & Cold Spring Harbor Laboratory

研究领域

Dr. Fiedler is the Florida Institute of Technology Associate Vice President for Research - Federal Government Relations & Partnerships.  Prior to his administrative appointment, Fiedler's research focused on genome biology and annotation.  The sequencing of the human and now numerous other genomes has launched a revolution in the way biological research is conducted, ushering in an era of data-driven hypotheses. This novel approach complements but does not replace traditional laboratory experiments which must be performed to validate leads obtained from large-scale studies. Dr. Fiedler's primary area of research interest is in genome biology, and specifically using computational approaches to annotate genome sequences. Programming using accessible scripting languages such as perl allows biologists the ability to rapidly handle massive datasets, discovering novel genes in sequenced genomes.

Dr. Fiedler is currently serving Florida Institute of Technology in the Office of Research focused on government relations and supporting faculty efforts to procure external funding, as well as coordinating the Biological Sciences Seminar & Dissertation courses (BIO 5990 & 5991).

近期论文

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Tristan J. Fiedler, A. Hudder, S.J. McKay, S. Shivkumar, T.R. Capo, M.C. Schmale, P.J. Walsh. 2010. The transciptome of the early life history stages of the California Sea Hare Aplysia californica. Comp Biochem Phys D. Epub accepted 29 Mar 2010 Tristan J. Fiedler, Claudiu M. Nelersa, Yuhong Zuo, Adviye A. Tolun and Arun Malhotra. 2010. Structure of Oligoribonuclease is Optimized for Degradation of Small Oligonucleotidese. manuscript in preparation. Tristan J. Fiedler, Darin Blasiar, Avril Coghlan, Paul Flicek, Todd W. Harris, Sheldon J. McKay, Lincoln D. Stein. 2008. nGASP: the nematode Genome Annotation Assessment Project. BMC Bioinformatics. 9(1):549 Rogers A, Antoshechkin I, Bieri T, Blasiar D, Bastiani C, Canaran P, Chan J, Chen WJ, Davis P, Fernandes J, Fiedler TJ, Han M, Harris TW, Kishore R, Lee R, McKay S, Mller HM, Nakamura C, Ozersky P, Petcherski A, Schindelman G, Schwarz EM, Spooner W, Tuli MA, Van Auken K, Wang D, Wang X, Williams G, Yook K, Durbin R, Stein LD, Spieth J, Sternberg PW. WormBase 2007. Nucleic Acids Res. 2008 Jan;36(Database issue):D612-7. Epub 2007 Nov 8. Girard*, L. R., Fiedler*, T. J., Harris, T. W., Carvalho, F., Antoshechkin, I., Han, M., Sternberg, P. W., Stein, L. D., Chalfie, M. 2007. WormBook: the online review of C. elegans biology. NAR 35(Database issue):D472-5. Epub 2006 Nov 11. *equal contributors Tamberlyn Bieri, Darin Blasiar, Philip Ozersky, Igor Antoshechkin, Carol Bastiani, Payan Canaran, Juancarlos Chan, Nansheng Chen, Wen J. Chen, Paul Davis, Tristan J. Fiedler, Lisa Girard, Michael Han,Todd W. Harris, Ranjana Kishore, Raymond Lee, Sheldon McKay, Hans-Michael Mueller, Cecilia Nakamura, Andrei Petcherski, Anthony Rogers, Gary Schindelman, Erich M. Schwarz, Will Spooner, Mary Ann Tuli, Kimberly Van Auken, Daniel Wang, Xiaodong Wang, Gary Williams, Richard Durbin, Lincoln D. Stein, Paul W. Sternberg, and John Spieth. . WormBase: New Content and Better Access. 2007. NAR 35(Database issue):D506-10. Epub 2006 Nov 11. caBIG Data Sharing and Intellectual Capital Work Group. 2006. Proposed Policy for Sharing of Data Obtained in NIH Supported or Conducted Genome-Wide Association Studies (GWAS) - Response by caBIG. November 30, 2006. Response to Sally J. Rockey, Ph.D., Deputy Director for Extramural Research, NIH. Schwarz EM, Antoshechkin I, Bastiani C, Bieri T, Blasiar D, Canaran P, Chan J, Chen N, Chen WJ, Davis P, Fiedler TJ, Girard L, Harris TW, Kenny EE, Kishore R, Lawson D, Lee R, Mller HM, Nakamura C, Ozersky P, Petcherski A, Rogers A, Spooner W, Tuli MA, Van Auken K, Wang D, Durbin R, Spieth J, Stein LD, Sternberg PW. WormBase: better software, richer content. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D475-8. The WormBook Consortium. The Word on the Worm - Science NetWatch (April 14). 2006. 312: 169. Fiedler, T. J., Vincent, H. A., Zuo, Y., Gavrialov, O., Malhotra A. 2004. Purification and Crystallization of E. coli oligoribonuclease. Acta Crystallographica D. D60:736-739. Schrag, B., Ferrell, G., Weil, V., Fiedler, T. J. 2003. Barking up the wrong tree ? Industry funding of academic research. A case study with commentaries. Science & Engineering Ethics. 9(4):569-582. Blair-Johnson, M., Fiedler, T., and Fenna, R. 2001. Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 Angstrom resolution. Biochemistry. 40: 13990-13997. Davey, C., Fiedler, T., Fenna, R.E. 2000. Chapter 4: X-ray crystallographic studies of human myeloperoxidase. (in The Peroxidase Multigene Family of Enzymes: Biochemical Basis and Clinical Applications, Petrides, P.E. & Nauseef, W. M., editors) Springer Publishing Company, Heidelberg, New York. June 2000. Fiedler, T. J., Davey, C. A., Fenna, R. E. 2000. X-ray crystal structure and characterization of halide binding sites of human myeloperoxidase at 1.8 Angstrom resolution. Journal of Biological Chemistry. 275(16): 11964 - 11971. Zhang Y, Malinovskii VA, Fiedler TJ, Brew K. Role of a conserved acidic cluster in bovine beta1,4 galactosyltransferase-1 probed by mutagenesis of a bacterially expressed recombinant enzyme. Glycobiology. 1999 Aug;9(8):815-22. Corollo D, Blair-Johnson M, Conrad J, Fiedler T, Sun D, Wang L, Ofengand J, Fenna R. Crystallization and characterization of a fragment of pseudouridine synthase RluC from Escherichia coli. Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):302-4. Epub 1999 Jan 1.