Christopher, Bashur - Florida Institute of Technology

个人简介

The core focus of my research involves elucidating how cells interact with their microenvironment (e.g., topography and scaffold composition) and using this knowledge to develop strategies to produce tissue engineered grafts. My lab works on the different stages necessary to develop clinical therapies: including (a) developing novel biomaterials, (b) exploring cell - microenvironment interactions, and (c) determining the viability of constructs in vivo. The primary goal of the lab is overcoming the current limitations to engineering small-diameter vascular grafts, which include the lack of a functional endothelium and limited elastic matrix production. Ph.D., Chemical Engineering, Virginia Tech M.Eng., Chemical Engineering, Virginia Tech B.S., Chemical Engineering, Lafayette College

研究领域

-Engineering Conduit Composition to Promote Elastogenesis and Endothelialization in Small-Diameter Vascular Graft (previously funded by the American Heart Association). -Novel biomaterials with light-controlled CO release for modulation of endothelial cells (funded by the National Science Foundation)

近期论文

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Birthare, K., M. Shojaee, C.G. Jones, J.R. Brenner, C.A. Bashur, Collagen incorporation within electrospun conduits reduces lipid oxidation and impacts conduit mechanics. Biomedical Materials, 2016, 11(2): 025019. Michael, E., N. Abeyrathna, A.V. Patel, Y. Liao, C.A. Bashur, Incorporation of photo-carbon monoxide releasing materials into electrospun scaffolds for vascular tissue engineering. Biomedical Materials, 2016, 11(2): 025009. Nguyen, T., C.A. Bashur, V. Kishore, Impact of elastin incorporation into electrochemically aligned collagen fibers on mechanical properties and smooth muscle cell phenotype. Biomedical Materials, 2016, 11(2): 025008. Venkataraman, L., C.A. Bashur, A. Ramamurthi, Impact of Cyclic Stretch on Induced Elastogenesis within Collagenous Conduits. Tissue Engineering Part A, 2014, 20(9-10): p.1403-15. Bashur, C.A., A. Ramamurthi, Composition of Intraperitoneally-Implanted Electrospun Conduits Modulates Cellular Elastic Matrix Generation. Acta Biomaterialia, 2014, 10(1): p.163-72. Bashur, C.A., M.J. Eagleton, A. Ramamurthi, Impact of Electrospun Conduit Fiber Diameter and Enclosing Pouch Pore Size on Vascular Constructs Grown within Rat Peritoneal Cavities. Tissue Engineering Part A, 2013, 19(7-8): p.809-23 Bashur, C.A., A. Ramamurthi, Aligned Electrospun Scaffolds and Elastogenic Factors for Vascular Cell-mediated Elastic Matrix Assembly. Journal of Tissue Engineering and Regenerative Medicine, 2012, 6 (9): p. 673–686 Lee, J.Y., C.A. Bashur, A.S. Goldstein, C.E. Schmidt, Nerve Growth Factor-Immobilized Electrically Conducting Fibrous Scaffolds for Potential Use in Neural Engineering Applications. IEEE Transactions on NanoBioscience, 2012. 11(1): p. 15-21 McMahon, B.S., X. Qu, A.C. Jimenez-Vergara, C.A. Bashur, S.A. Guelcher, A.S. Goldstein, M.S. Hahn, Hydrogel-electrospun Mesh Composites for Coronary Artery Bypass Grafts. Tissue Engineering part C, 2011. 17(4): p. 451-461. Lee, J.Y., C.A. Bashur, N. Gomez, A.S. Goldstein, C.E. Schmidt, Enhanced Polarization of Embryonic Hippocampal Neurons on Electrospun Poly(lactic acid-co-glycolic acid) Fibers. Journal of Biomedical Materials Research part A, 2010. 92(4): p. 1398-1406. Lee, J.Y., C.A. Bashur, A.S. Goldstein, C.E. Schmidt, Polypyrrole-coated Electrospun PLGA Nanofibers for Neural Tissue Applications. Biomaterials, 2009. 30(26): p. 4325-4335. Bashur, C.A., R.D. Shaffer, L.A. Dahlgren, S.A. Guelcher, and A.S. Goldstein, Effect of Fiber Diameter and Orientation of Electrospun Polyurethane Meshes on Ligament Progenitor Cells. Tissue Engineering part A, 2009. 15(9): p. 2435-2445. Stylianopoulos, T., C.A. Bashur, A.S. Goldstein, S.A. Guelcher, and V.H. Barocas, Computational Predictions of the Tensile Properties of Electrospun Fiber Meshes: Effect of fiber diameter and fiber orientation. Journal of the Mechanical Behavior of Biomedical Materials, 2008. 1 (4): p. 326-335. Bashur, C.A., L.A. Dahlgren, and A.S. Goldstein, Effect of Fiber Diameter and Orientation on Fibroblast Morphology and Proliferation on Electrospun Poly(D,L-lactic-co-glycolic acid) Meshes. Biomaterials, 2006. 27(33): p. 5681-5688. Fenn, M.B., N. Roki, C.A Bashur, Silica-coated gold nanostars for surface-enhanced resonance Raman spectroscopy mapping of integrins in breast cancer cells. Plasmonics in Biology and Medicine / SPIE (International Society for Optics and Photonics), March 2015. Shojaee, M., Bashur, C.A. Compositions Including Synthetic and Natural Blends for Integration and Structural Integrity: Engineered for Different Vascular Graft Applications. Advanced Healthcare Materials, 2017. Invited progress report, Epublished ahead of print. Bashur, C.A., R.R. Rao, A. Ramamurthi, Perspectives on stem cell-based elastic matrix regenerative therapies for abdominal aortic aneurysms. Stem Cells Translational Medicine, 2013, 2(6): p. 401-8. Sivaraman, B., C.A. Bashur, A. Ramamurthi, Advances in Biomimetic Regeneration of Elastic Matrix Structures. Drug Delivery and Translational Research, 2012. 2: p.323-350. Bashur, C.A., L. Venkataraman, A. Ramamurthi , Tissue Engineering Strategies to Replicate Biocomplexity of Vascular Elastic Matrix Assembly. Tissue Engineering part B, 2012. 18(3): p. 203-217.