Jiao, Shuliang - Florida International University - Department of Biomedical Engineering

研究领域

With aging of the population vision loss is becoming a major public health problem worldwide. According to NEI, blindness or low vision affects 3.3 million Americans age 40 and over and it is projected to reach 5.5 million by the year 2020. In US most types of blindness and low vision are related to retinal diseases. The diagnosis and treatment monitoring for retinal diseases highly rely on in vivo imaging technologies. The long term goal of Dr. Jiao’s research is to help prevent and cure blindness through technological innovations. Dr. Jiao’s lab, the Ophthalmic Imaging Lab, is dedicated to the development of novel optical technologies for 3D high resolution imaging of the anatomy and functions of the eye in vivo. The optical imaging technologies the lab currently focuses on include Optical Coherence Tomography (OCT), Photoacoustic Microscopy, and Multimodal Imaging. These technologies serve as tools for the research and diagnosis of diseases such as age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy. They also provide powerful tools for monitoring the functional regeneration of photoreceptors in regenerative medicine such as stem cell therapy. Optical Coherence Tomography OCT is a low-coherence interferometer-based noninvasive medical imaging modality that can provide high-resolution sectional images of biological tissues. Since it was first reported more than two decades ago, OCT has been used in a variety of medical research and diagnostic applications with the most successful being in ophthalmology for retinal sectional imaging. The interference signals of OCT can be detected in either time domain (TD-OCT) or spectral domain (SD-OCT). Spectral-domain detection has the advantages of fast imaging speed and better signal-to-noise ratio. Currently, SD-OCT has become one of the major retinal imaging techniques in ophthalmic clinics. Dr. Jiao’s lab pioneered the use of high resolution SD-OCT in imaging small animal models of ocular diseases. Currently, SD-OCT plays an important role in ophthalmic research using animal models. Photoacoustic Microscopy PAM is an optical-absorption based microscopic imaging modality that detects laser-induced ultrasonic waves (photoacoustic waves) as a result of specific optical absorption. Photoacoustic ophthalmoscopy (PAOM) is a branch of PAM. PAOM is capable of imaging the physiologically-specific optical absorption contrast in the retina, which is missing in all existing ophthalmic imaging modalities. PAOM was first introduced in 2010 by Dr. Jiao’s lab together with his collaborators and has since achieved high-speed, high-resolution in vivo imaging of the vasculature of the retina and the pigmentation of the RPE in small animals. Multimodal imaging Multimodal imaging takes advantages of combining different contrast mechanisms to provide comprehensive anatomical and functional information of biological tissues. PAOM and OCT, PAOM and autofluorecence imaging, and OCT and autofluorescence imaging are imaging modalities that can provide complementary contrasts for imaging biological tissues and are good candidates for an integrated multimodal system.

近期论文

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1. C. Dai, X. Liu, H. F. Zhang, C. A. Puliafito, and S. Jiao, “Absolute retinal blood flow measurement with a dual-beam Doppler optical coherence tomography”, Investigative Ophthalmology & Visual Science 54, 7998–8003 (2013). 2. X. Liu, C.-H. Wang, C. Dai, A. Camesa, H. F. Zhang, and S. Jiao, “Effect of contact lens on optical coherence tomography imaging of rodent retina,” Current Eye Research, 38(12), 1235-1240 (2013). 3. T. Liu, H. Li, W. Song, S. Jiao, and H. F. Zhang, “Fundus camera guided photoacoustic ophthalmoscopy,” Current Eye Research, 38(12), 1229-1234 (2013). 4. Wenzhong Liu, Shuliang Jiao, Hao F. Zhang, “Accuracy of retinal oximetry: a Monte Carlo investigation”, J Biomed Opt. 18(6):66003 (2013). 5. Ji Yi, Wenzhong Liu, Shuliang Jiao, and Hao F. Zhang, “Combining light and sound for retinal imaging”, SPIE Newsroom, 19 March 2013, DOI: 10.1117/2.1201303.004764. 6. Tan Liu, Hao F. Zhang and Shuliang Jiao, “Watching while listening to the interaction of photons with bio-tissues”, SPIE Newsroom, 3 January 2013. DOI: 10.1117/2.1201212.004580 7. F. Zheng, X. ZhangS, C. Tat Chiu, B. L. Zhou, K. Kirk Shung, H. F. Zhang, and S. Jiao, “Laser-scanning photoacoustic microscopy with ultrasonic phased array transducer”, Biomed. Opt. Express 3, 2694–2699 (2012). 8. Wei Song, Qing Wei, Liang Feng, Vijay Sarthy, Shuliang Jiao, Xiaorong Liu, Hao F. Zhang, “Multimodal photoacoustic ophthalmoscopy in mouse”, Journal of Biophotonics, 2012. DOI: 10.1002/jbio.201200061. 9. W. Song, Q. Wei, S. Jiao, and H.F. Zhang, “Integrated photoacoustic ophthalmoscopy and spectral-domain optical coherence tomography,” Journal of Visualized Experiments 71, e4390 (2013). 10. C. DaiS, X. LiuS, S. Jiao, “Simultaneous optical coherence tomography and autofluorescence microscopy with a single light source”, J. Biomed. Opt. 17, 080502-1– 080502-3 (2012). 11. M. JiangS, P. C. Wu, M. Elizabeth Fini, C. L. Tsai, T. Itakura, X. ZhangS, and S. Jiao, “Single shot dimension measurements of mouse eye using spectral-domain optical coherence tomography”, Ophthalmic Surgery and Lasers & Imaging 43, 251-256 (2012). 12. Wei Song, Qing Wei, Tan Liu, David Kuai, Janice M. Burke, Shuliang Jiao, and Hao F. Zhang, “Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform” J. Biomed. Opt. 17, 061206-1–061206-7 (2012). 13. Tan Liu, Qing Wei, Wei Song, Janice M. Burke, S. Jiao, and Hao F. Zhang, “Near-infrared light photoacoustic ophthalmoscopy,” Biomed. Opt. Express 3, 792-799 (2012) http://opticsinfobase.org/boe/abstract.cfm?URI=boe-3-4-792. 14. X. Y. ZhangS, H. F. Zhang, C. A. Puliafito, and S. Jiao, “Optical Coherence Photoacoustic Microscopy: accomplishing optical coherence tomography and photoacoustic microscopy with a single light source”, J. Biomed. Opt. 17, 030502 (2012). 15. C. Dai, C. Zhou, S. Fan, Z. Chen, X. Chai, Q. Ren, and S. Jiao, “Optical coherence tomography for whole eye segment imaging”, Optics Express 20, 6109–6119 (2012). 16. X. Y. ZhangS, J. HuS, R. W. Knighton, X-R Huang, C. A. Puliafito, and S. Jiao, “Dual-band spectral-domain optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer”, Optics Express 19, 19653-19659 (2011). 17. H. F. Zhang, C. A. Puliafito, and S. Jiao, “Photoacoustic ophthalmoscopy for in vivo retinal imaging: current status and prospects”, Ophthalmic Surgery and Lasers 42, No. 4 (Suppl), S106–S115 (2011). 18. X. Y. ZhangS, H. F. Zhang, C. A. Puliafito, and S. Jiao, “Simultaneous in vivo imaging of melanin and lipofuscin in the retina with multimodal photoacoustic ophthalmoscopy”, J. Biomed. Opt. 16, 080504 (2011); doi:10.1117/1.3606569. 19. Qing Wei, Tan Liu, S. Jiao, and Hao F. Zhang, “Image chorioretinal vasculature in albino rats using photoacoustic ophthalmoscopy”, Journal of Modern Optics, 58, 1997–2001 (2011). 20. T. Liu, Q. Wei, J. Wang, S. Jiao, and H. F. Zhang, “Combined photoacoustic microscopy and optical coherence tomography can measure metabolic rate of oxygen”, Biomedical Optics Express 2, 1147–1158 (2011). * Senior/corresponding author 21. M. S. JiangS, X. ZhangS, C. A. Puliafito, H. F. Zhang, and S. Jiao, “Adaptive optics photoacoustic microscopy”, Optics Express 18, 21770-21776 (2010). 22. X. Y. ZhangS, M. S. JiangS, A. A. Fawzi, X. A. Li, K. K. Shung, C. A. Puliafito, H. F. Zhang, and S. Jiao, “Simultaneous dual molecular contrasts provided by the absorbed photons in photoacoustic microscopy,” Optics Letters 35, 4018-4020 (2010). 23. M. RuggeriS, J. C. Major Jr., C. McKeown, H. WehbeS, R. W. Knighton, C. A. Puliafito, and S. Jiao “Retinal Structure of Birds of Prey Revealed by Ultra-High Resolution Spectral-Domain Optical Coherence Tomography”, Investigative Ophthalmology & Visual Science 51, 5789-5795 (2010). 24. Mohamed Abou Shousha, Victor L. Perez, Jianhua Wang, Takeshi Ide, S. Jiao, Qi Chen, Victoria Chang, Nancy Buchser, Sander R. Dubovy, William Feuer, Sonia H. Yoo, “Use of Ultra High Resolution Optical Coherence Tomography to Detect In Vivo Characteristics of Descemet’s Membrane in Fuchs’ Dystrophy,” Ophthalmology 117, 1220-1227 (2010). 25. Jing Wang, Tan Liu, S. Jiao, Ruimin Chen, Qifa Zhou, K. Kirk Shung, Lihong V. Wang, Hao F. Zhang, “Saturation effect in functional photoacoustic imaging,” J. Biomed. Opt. 15, 021317-1 – 021317-5 (2010).