HUTCHESON, JOSHUA - Florida International University - Department of Biomedical Engineering

个人简介

Dr. Hutcheson is excited to join the Department of Biomedical Engineering at Florida International University! He most recently worked as a research fellow at Brigham and Women’s Hospital and Harvard Medical School within the Center for Interdisciplinary Cardiovascular Sciences. Dr. Hutcheson is passionate about teaching and researching the mechanisms of cardiovascular tissue maintenance and remodeling. Outside of the lab and classroom, Dr. Hutcheson enjoys spending time with his wife and agonizing over Atlanta sports teams. 2008 – 2012 Vanderbilt University Ph.D. Biomedical Engineering 2006 – 2008 Georgia Institute of Technology M.S. Chemical Engineering 2001 – 2005 Georgia Institute of Technology B.S. Chemical and Biomolecular Engineering Tweets by joshdhutch

研究领域

Resolution of Cardiovascular Fibrocalcific Remodeling Inflammation-driven fibrocalcific remodeling of cardiovascular tissues is a leading cause of death. Anti-inflammatory treatments have proven ineffective at preventing this remodeling. We are exploring natural inflammation resolution therapies that promote homeostasis and tissue regeneration. This could lead to a clinical treatment for this currently untreatable condition. Super Resolution View of Biomineralization Biomineralization is an important part of bone physiology but is detrimental to the function of cardiovascular tissues. Any viable therapy for cardiovascular calcification or osteoporosis must affect one tissue without off target effects in the other. We are using advanced imaging and material-based analyses to identify overlapping and divergent mechanisms in these processes. Cellular Contributions in Aortic Valve Development and Disease The aortic valve has poorly defined cellular populations. The cellular complexity arises from different embryonic origins. We are studying the interactions between the different cell populations in the aortic valve to discover new therapies for aortic valve disease and to design tissue engineered valve replacements. Cytoskeletal Alterations and Extracellular Matrix Remodeling Extracellular matrix components that compose tissues are released from cells in a controlled manner that involves trafficking of small vesicles. The local mechanical environment of the cell influences the cell cytoskeleton and the release of extracellular matrix. We are studying how cytoskeletal changes alter trafficking of intracellular vesicles and release of extracellular matrix components. Outcomes of this study could lead to treatments for fibrotic remodeling of soft tissues and more rational designs for engineered tissue replacements.

近期论文

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R Krammann, C Goettsch, J Wongboonsin, H Iwata, RK Schneider, C Kuppe, N Kaesler, M Chang-Panesso, F Machado, S Gratwohl, C Vemuri, K Madhurima, JD Hutcheson, S Jain, E Aikawa, BD Humpreys, “Adventitial MSC-like cells are progenitors of vascular smooth muscle cells and drive vascular calcification in chronic kidney disease”, Accepted, Cell Stem Cell, 2016. Link to Publication C Goettsch*, JD Hutcheson*, S Hagita*, M Rogers, MD Creager, T Pham, J Choi, AK Mlynarchik, MF Kjolby, M Aikawa, E Aikawa, “A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification”, In press, Atherosclerosis, 2016. *Equal Contribution Link to Publication J Krohn, JD Hutcheson*, E Martinez-Martinez, WS Irvin, S Bertazzo, CVC Bouten, MP Bendeck, E Aikawa*, “Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via TGF-β Signaling”, In press, Arteriosclerosis, Thrombosis, and Vascular Biology, 2015. *Co-corresponding authors Link to Publication JD Hutcheson, C Goettsch, S Bertazzo, N Maldonado, JL Ruiz, W Goh, K Yabusaki, T Faits, C Bouten, P Libby, M Aikawa, S Weinbaum, E Aikawa, “High-resolution microscopic visualization of vascular calcification genesis, growth, and association with collagen in atherosclerotic plaques”, In press, Nature Materials, 2015. C Goettsch, JD Hutcheson, M Aikawa, A Nykjaer, M Kjolby, M Rogers, T Michel, M Shibasaki, DJ Rader, P Libby, SA Singh, E Aikawa, “Sortilin mediates vascular calcification via its recruitment into extracellular vesicles”, In press, Journal of Clinical Investigation, 2015. Link to Publication JD Hutcheson, C Goettsch, MA Rogers, E Aikawa, “Revisiting Cardiovascular Calcification: A Multifaceted Disease Requiring a Multidisciplinary Approach”, Invited Review, Seminars in Cell and Developmental Biology, In press, 2015. Link to Publication J Hjortnaes, K Shapero, C Goettsch, JD Hutcheson, J Keegan, J Kluin, JE Mayer, J Bischoff, E Aikawa, “Valvular Interstitial Cells Suppress Calcification of Valvular Endothelial Cells”, Atherosclerosis, 242(1): 251-260, 2015. Link to Publication J Ruiz, JD Hutcheson, E Aikawa, “Cardiovascular Calcification: Current Controversies and Novel Concepts”, Invited Review, Cardiovascular Pathology, 10(7), 2015. Link to Publication JD Hutcheson, C Goettsch, T Pham, M Aikawa, SA Singh, E Aikawa, “Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol”, Journal of Extracellular Vesicles, Dec 5;3:25129, 2014. Link to Publication JD Hutcheson, N Maldonado, E Aikawa, “Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability”, Current Opinion in Lipidology, 25(5):327-32, 2014. Link to Publication JD Hutcheson, E Aikawa, WD Merryman, “Potential drug targets for calcific aortic valve disease”, Nature Reviews Cardiology, 11(4): 218-31, 2014. Link to Publication C Goettsch, JD Hutcheson, and E Aikawa, “MicroRNA in cardiovascular calcification: Focus on targets and extracellular vesicle delivery mechanisms”, Circulation Research, 112(7): 1073-84, 2013. Link to Publication JD Hutcheson, J Chen, MK Sewell-Loftin, LM Ryzhova, CI Fisher, YR Su, WD Merryman, “Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts”, Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 33(1): 114-20, 2013. Link to Publication JD Hutcheson, L Ryzhova, V Setola, and WD Merryman, “5-HT2B antagonism arrests non-canonical TGF-β1-induced myofibroblast differentiation”, Journal of Molecular and Cellular Cardiology, 53(5): 707-714, 2012. JD Hutcheson, R Venkataraman, FJ Baudenbacher, and WD Merryman, “Intracellular Ca2+ accumulation is strain-dependent and correlates with apoptosis in aortic valve fibroblasts”, Journal of Biomechanics, 45(5): 888-894, 2012. Link to Publication JD Hutcheson, V Setola, BL Roth, and WD Merryman, “Serotonin Receptors and Heart Valve Disease—It Was Meant 2B”, Phamacology & Therapeutics, 132(2): 146-157, 2011. Link to Publication