Xiao, Yi - Florida International University - Department of Chemistry and Biochemistry

研究领域

Use of biotechnologies to generate new biomaterials that combine with nanomaterials to develop amplified, robust and disposable biosensors for specific in vitro or in vivo sensing at point-of-care. Nanomaterial-Based Biosensors DNA-Based Biosensors In vitro Directed Evolution

近期论文

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(68) Yu H.X., Xu X.W., Liang P.P., Loh K.Y., Guntupalli B., Roncancio D. Xiao Y. "A broadly-applicable assay for rapidly and accurately quantifying DNA surface coverage on diverse particles." Bioconjugate Chem. 28, 933 – 943, 2017. (67) Yu, H.X., Canoura J., Guntupalli B., Lou X.H. Xiao Y. "A Cooperative-Binding Split Aptamer Assay for Rapid, Specific and Ultra-Sensitive Fluorescence Detection of Cocaine in Saliva." Chem. Sci. 8, 131 – 141, 2017. (66) Xu Q., Lou X.H., Wang L., Ding X.F., Yu H.X.Xiao Y. "Rapid, surfactant-free, and quantitative functionalization of gold nanoparticles with thiolated DNA under physiological pH and its application in molecular beacon-based biosensor." ACS Appl. Mater. Interfaces. 8, 27298 – 27304, 2016. (65) Guntupalli B., Liang P.P., Lee, J.H., Yang Y.H., Yu, H.X., Canoura J., He J., Li W.Z., Weizmann Y. Xiao Y. "Ambient Filtration Method to Rapidly Prepare Highly Conductive, Paper-Based Porous Gold Films for Electrochemical Biosensing." ACS Appl. Mater. Interfaces. 7, 27049-27058, 2015. (64) Zhao T., Liu R., Yu H.X., Zhao J.C., Wang X., Lou X.H. Xiao Y. “A Nanoprobe-Enhanced, Split Aptamer-Based Electrochemical Sandwich Assay for Ultrasensitive Detection of Small Molecules.” Anal. Chem. 87, 7712-7719, 2015. (63) Liang P.P., Yu H.X. Guntupalli B. & Xiao Y. “Paper-Based Device for Rapid Visualization of NADH Based on Dissolution of Gold Nanoparticles.” ACS Appl. Mater. Interfaces. 7, 15023-15030, 2015. (62) Roncancio D., Yu H.X., Xu X.W., Wu S., Liu R., Debord J., Lou X.H. & Xiao Y. “A Label-Free Aptamer-Fluorophore Assembly for Rapid and Specific Detection of Cocaine in Biofluids.” Anal. Chem. 86, 11100-11106 2014. (61) Wu S., Liang P.P., Yu H.X., Xu X.W., Liu Y., Lou X.H. & Xiao Y. “Amplified Single Base-Pair Mismatch Detection via Aggregation of Exonuclease-Sheared Gold Nanoparticles.” Anal. Chem. 86, 3461-3467 2014. (60) Lou X.H., Zhao T., Liu R., Ma, J.S. & Xiao Y. “Self-Assembled DNA Monolayer Buffered Dynamic Ranges of Mercuric Electrochemical Sensor.” Anal. Chem. 85, 7574-7580, 2013. (59) Oh S.S., Plakos K., Xiao Y. & Soh H.T. “In Vitro Selection of Shape-Changing DNA Nanostructures Capable of Binding-Induced Cargo Release.” ACS Nano. 7, 9675-9683, 2013. (58) Deborggraeve S., Dai J.Y., Xiao Y. & Soh H.T. “Controlling the Function of DNA Nanostructures with Specific Trigger Sequences.” Chem. Comm. 49, 397-399, 2013. (57) Ahmad K.M., Xiao Y. & Soh H.T. “Selection is More Intelligent Than Design: Improving the Affinity of a Bivalent Aptamer Through Directed Evolution.” Nucleic Acids Res. 40, 11777-117843, 2012. (56) Feng L.Y., Zhao C.Q., Xiao Y., Wu L., Ren J.S. & Qu X.G. “Electrochemical DNA Three-Way Junction Based Sensor for Distinguishing Chiral Metallo-Supramolecular Complexes.” Chem. Comm. 48, 6900-6902, 2012. (55) Olmsted I.R., Xiao Y., Cho M., Csordas A., Sheehan J.H, Meiler J., Soh H.T. & Bornhop D.J. “Measurement of Aptamer-Protein Interactions with Back-Scattering Interferometry.” Anal. Chem. 83, 8867-8870, 2011. (54) Ahmad K.M., Oh S.S., Kim S., Xiao Y. & Soh H.T. “Probing the Limits of Aptamer Affinity with a Microfluidic SELEX Platform.” PLoS One 6, e27051, 2011. (53) Zuo X.L., Xia F., Patterson A., Soh H.T., Xiao Y. & Plaxco K.W. “Two-Step, PCR-Free Telomerase Detection by Using Exonuclease III-Aided Target Recycling.” ChemBioChem. 12, 2745-2747, 2011. (52) Hsieh K.W., White R.J., Ferguson B.S., Xiao Y. & Soh H.T. “Polarity-Switching Electrochemical Sensor for Specific Detection of Single-Nucleotide Mismatches.” Angew. Chem. Int. Ed. 50, 11176-11180, 2011. (51) Oh S.S., Ahmad K.M., Cho M., Kim S., Xiao Y. & Soh H.T. “Improving Aptamer Selection Efficiency Through Volume Dilution, Magnetic Concentration, and Continuous Washing in Microfluidic Channels.” Anal. Chem. 83, 6883-6889, 2011. (50) Ferguson B.S., Buchsbaum S.F., Wu T.-T., Hsieh K., Xiao Y., Sun R. & Soh H.T. “Integrated Genetic Analysis of H1N1 Influenza Virus in a Monolithic Microfluidic System.” J. Am. Chem. Soc. 133, 9129-9135, 2011. (49) Wang J.P., Liu Y.L., Teesalu T., Sugahara K., Kotamrajua V.R., Adams J.D., Ferguson B.S., Gong Q., Oh S.S., Csordas A.T., Ruoslahti E., Xiao Y. & Soh H.T. “Selection of Phage-Displayed Peptides on Live Adherent Cells in Microfluidic Channels.” Proc. Natl. Acad. Sci. U.S.A. 108, 6909–6914, 2011.