Miksovska, Jaroslava - Florida International University - Department of Chemistry and Biochemistry

个人简介

B.S. Charles University in Prague, Czech Republic - M.S. Charles University in Prague, Czech Republic - Ph.D. University Paris XI – Orsay, France

研究领域

Biochemistry Biophysics Structure – function relationship in proteins Ligand-protein interactions Heme proteins Calcium binding proteins Photothermal methods.

近期论文

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1. Tiwari P. B., Astudillo L., Wang X., He J., Bernad S., Derrien V., Sebban P., Miksovska, J., and Darici Y., �Surface Plasmon Resonance Study of Molecular Interaction of Neuroglobin binding to Cytochrome c� (2013) submitted 2. Gonzalez, W. and Miksovska, J. (2013).� Sub-miliscond conformational changes in protein resolved by photothermal beam deflection. JoVe, in print 3. Astudillo L, Bernad S, Derrien V, Sebban P, Miksovska J. (2013)�Reduction of the internal disulfide bond between Cys 38 and 83 switches the ligand migration pathway in cytoglobin.�J Inorg Biochem. Aug 16;129C: 23-29. 4. Adjaye-Mensah, E.; Gonzalez, W.; Miksovska, J., Wilson, J. (2012) �Photophysical Characterization of a Benzo-Fused Analogue of Brooker�s Merocyanine: Solvent Polarity and pH Effects�J Phys Chem A. 2012 Dec 27;116(51):12470-5. 5. Astudillo L, Bernad S, Derrien V, Sebban P, Miksovska J. (2012) �Conformational dynamics in human neuroglobin: the effect of His 64, Val 68 and Cys 120 on ligand migration.� Biochemistry Dec 18;51(50):9984-94. 6. Li S, Aphale A, Macwan I, Patra PK, Gonzalez WG, Miksovska J, Leblanc RM. (2012) �Graphene Oxide as a Quencher for Fluorescent Assay of Amino Acids, Peptides and Proteins.�ACS Appl Mater Interfaces. 2012 Dec;4(12):7069-75. 7. Adjaye-Mensah E, Gonzalez WG, Buss� DR, Captain B, Miksovska J, Wilson JN. (2012) Emission switching of 4,6-diphenylpyrimidones:solvent and solid state effects. J. Phys. Chem. A 116 1-7. 8. Gantar M, Simović D, Djilas S, Gonzalez W. G., Miksovska J. (2012) �Isolation, characterization and antioxidative activity of C-phycocyanin from Limnothrix sp. strain 37-2-1.� J Biotechnol. 159 (1-2): 21-26. 9. Larsen RW, Miksovska J, Musselman RL, Wojtas L. (2011) �Ground- and excited-state properties of Zn(II) tetrakis(4-tetramethylpyridyl) pophyrin specifically encapsulated within a Zn(II) HKUST metal-organic framework.� J Phys Chem A. 115(42):11519-24.� 10. Horsa, S., K. Perez, and Miksovska, J. (2011) "Functionalization of rho-ZMOF with Photosensitizers for Singlet Oxygen Generation." J. Photochem. A. Photobiol. A: Chemistry 221:84�89. 11. Vetromile, C. M., J. Miksovska, and Larsen, R.W*. "Time resolved thermodynamics associated with ligand photorelease in heme peroxidases and globins: Open access channels versus gated ligand release. (2011) Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics 1814 (8):1065-76 12. Astudillo,J.,� Bernad, S., Derrien, V., Sebban, P., and Miksovska, J.*, (2010). "Probing the role of the internal disulfide bond in regulating conformational dynamics in neuroglobin." Biophys J 99(2): L16-18. Dhulipala, G., M. Rubio, Michael, K. and Miksovska, J.* (2009). "Thermodynamic profile for urea photo-release from a N-(2-nitrobenzyl) caged urea compound." Photochem Photobiol Sci 8(8): 1157-1163. 14. Jasuja R.*, Ulloor J, Yengo C.M., Choong K., Istomin A.Y., Livesay D.R., Jacobs, D.J., Swerdloff, R., Miksovska, J., Larsen, R.W., and Bhasin, S., (2009). "Kinetic and thermodynamic characterization of dihydrotestosterone-induced conformational perturbations in androgen receptor ligand-binding domain." Mol Endocrinol 23(8): 1231-1241 15. Miksovska, J.*, Horsa S., Davis M.D. and Franzen, S. (2008) �Conformational dynamics associated with photodissociation of CO from dehaloperoxidase studied using photoacoustic calorimetry.� Biochemistry 47(44): 11510-11517. 16. Belogortseva, N., M. Rubio M., Terrel, W. and Miksovska, J*. �(2007). "The contribution of heme propionate groups to the conformational dynamics associated with CO photodissociation from horse heart myoglobin." J Inorg Biochem 101(7): 977-986. 17. Larsen, R.W* and� Miksovska, J. (2007) �Time Resolved Thermodynamics of Ligand Binding to Heme Proteins� Coordination Chemistry Review 251 () 1045-1310. 18. Lockney, D. and J. Miksovska* (2006). "Characterization of carbon monoxide photodissociation from Fe(II)LPO with photoacoustic calorimetry." J Phys Chem B 110(47): 24165-24170. 19. Miksovska, J.* Yom, J., Dimond, B., and Larsen, R.W.� (2006). "Spectroscopic and photothermal study of myoglobin conformational changes in the presence of sodium dodecyl sulfate." Biomacromolecules 7(2): 476-482. 20. Miksovska, J., Gennis, R.B., and Larsen, R.W.* (2006). "Thermodynamics of carbon monoxide photodissociation from the fully reduced cytochrome aa3 oxidase from Rb. sphaeroides." Biochim Biophys Acta 1757(3): 182-188. 21. C, Stern AC, Green T., DeVane R., Brian Space B., Miksovska J. and. Larsen R.W*. (2006). "A combined photothermal and molecular dynamics method for determining molecular volume changes." Chemical Physics Letters 418(1-3): 137-141 22. Kuo, N. N.-W., Huang J. J.-T., Miksovska, J., Chen, R. P.-Y.,� Larsen R.W., Chan S.I.* (2005). "Effects of turn stability on the kinetics of refolding of a hairpin in a beta-sheet." J Am Chem Soc 127(48): 16945-16954. 23. Miksovska, J., Suquet C, Satterlee, J. D., and Larsen, R.W*. (2005). "Characterization of conformational changes coupled to ligand photodissociation from the heme binding domain of FixL." Biochemistry 44(30): 10028-10036. 24. Miksovska, J., Gennis, R.B., and Larsen, R.W*. (2005). "Photothermal studies of CO photodissociation from mixed valence Escherichia coli cytochrome bo3." FEBS Lett 579(14): 3014-3018. 25. Miksovska, J., J. Norstrom, Larsen, R.W*. (2005). "Thermodynamic profiles for CO photodissociation from heme model compounds: effect of proximal ligands." Inorg Chem 44(4): 1006-1014