个人简介

Ph.D., University of California at San Diego; NIH PostDoc in Physical Chemistry, Massachusetts Institute of Technology University, College of Arts and Sciences, A.B., Chemistry, 6/72. University of California, San Diego, Ph.D., Physical Chemistry, 7/77. Massachusetts Institute of Technology, NIH Postdoctoral Fellowship, 8/77-7/79.

研究领域

Polymer and Physical Chemistry, Molecular Biophysics, and Biochemistry

The Stark Laboratory uses structural biology approaches to study plant protective polymers, lipid metabolism, and potentially pathogenic melanized fungal cells. Nondestructive study of the molecular and mesoscopic architectures underlying the integrity of cuticles in natural and engineered tomatoes and potatoes is undertaken using solid-state nuclear magnetic resonance (NMR) and atomic force microscopy. Ligand recognition and peroxisome proliferator-activated receptor interactions of fatty acid-binding proteins are under investigation by solution-state NMR. The molecular structure and development of melanin pigments within fungal cells is probed using (bio)chemical synthesis and solid-state NMR.

近期论文

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T. Isaacson, D. Kosma, A.J. Matas, G.J. Buda, Y. He, B. Yu, A. Pravitasari, J. D. Batteas, R. E. Stark, M. A. Jenks and J. K. C. Rose, “Cutin deficiency in the tomato fruit cuticle consistently affects resistance to microbial infection and biomechanical properties, but not transpirational water loss,” The Plant J., 60, 363-377 (2009). H. Wu, K. Su, X. Guan, M.E. Sublette, and R. E. Stark, “Assessing the Size, Stability, and Utility of Isotropically Tumbling Bicelle Systems for Structural Biology,” Biochim. Biophys. Acta – Biomembranes, 1798, 482–488 (2010). doi:10.1016/j.bbamem.2009.11.004 W. Wang, S. Tian, and R.E. Stark, “Isolation and Identification of Triglycerides and Ester Oligomers from Partial Degradation of Potato Suberin,” J. Agric. Food Chem., 58, 1040-1045 (2010). X. Guan and R.E. Stark, “A General Protocol for Temperature Calibration of MAS NMR Probes at Arbitrary Spinning Speeds," Solid State NMR, 38, 74-76 (2010), doi: 10.1016/j.ssnmr.2010.10.001 Y. He, R. Estephan, X. Yang, A. Vela, H. Wang, C. Bernard, and R.E. Stark, “An NMR-Based Structural Rationale for Contrasting Stoichiometry and Ligand Binding Site(s) in Fatty Acid-binding Proteins,” Biochemistry, 50, 1283-1295 (2011), doi: 10.1021/bi101307h. A.J. Matas, T.H. Yeats, G.J. Buda, Y. Zheng, S. Chatterjee, T. Tohge, L. Ponnala, A.R. Fernie, R.E. Stark, J. Fei, J.J. Giovannoni, and J.K.C. Rose, “Tissue and cell type specific transcriptome profiling of expanding tomato fruit provides insights into metabolic and regulatory specialization and cuticle formation,” The Plant Cell, 23, 3893-3910 (2011). doi: 10.1105/tpc.111.091173 S. Chatterjee, S. Sarkar, J. Oktawiec, Z. Mao , and R.E. Stark, “Protocols for isolation and biophysical study of fruit cuticles,” invited article for Journal of Visualized Experiments, 61, e3529 (2012). J. Zhang, Y. Zhao, X. Guan, R.E. Stark, D.L. Akins, and J.W. Lee, “Formation of Graphene Oxide Nanocomposites from Carbon Dioxide Using Ammonia Borane,” J. Phys. Chem., 116, 2639–2644 (2012). O. Serra, W. Huang, S. Chatterjee, and R.E. Stark, "What Nuclear Magnetic Resonance Can Tell Us About Protective Tissues," invited mini-review for Plant Sci., 195, 120-124 (2012). S. Chatterjee, R. Prados-Rosales, S. Frases, B. Itin, A. Casadevall, and R.E. Stark, "Using Solid-state NMR to Monitor the Molecular Consequences of Cryptococcus neoformans Melanization with Different Catecholamine Precursors," Biochemistry, 51, 6080-6088 (2012). S. Chatterjee, F. Santos, S. Abiven, R.E. Stark, and J.A. Bird, "Elucidating the chemical structure of pyrogenic organic matter by combining magnetic resonance, mid-infrared spectroscopy and mass spectrometry," Org. Geochem. 51, 35-44 (2012). S. Sarkar, S. Chatterjee, N. Medina, and R.E. Stark, "Touring the Tomato: A Suite of Chemistry Laboratory Experiments," J. Chem. Educ. 90, 368-371 (2013). W.S. Lagakos, X. Guan, S.-Y. Ho, L.R. Sawicki, B. Corsico, K. Murota, R.E. Stark, and J. Storch, "Liver Fatty Acid-binding Protein Binds Monoacylglycerol in vivo and in Mouse Liver Cytosol," J. Biol. Chem., 288, 19805-19815 (2013). R.E. Stark, B. Yu, J. Zhong, B. Yan, G. Wu, and S. Tian, “Environmental NMR: High-resolution Magic-angle Spinning,” invited overview for “NMR Spectroscopy: A Versatile Tool for Environmental Research,” M. Simpson and A. Simpson, Eds., eMagRes, Wiley Online Library, 2, 377-388 (2013). T.H. Yeats, W. Huang, S. Chatterjee, H. M-F. Viart, M.H. Clausen, R. E. Stark, and J.K.C. Rose, “Biochemical characterization of CD1 and Putative Orthologs Reveals an Ancient Family of Cutin Synthase-like (CUS) Proteins that are Conserved Among Land Plants,” The Plant J., 77, 667-675 (2014). FEATURED ARTICLE. O. Serra, S. Chatterjee, M. Figueras, M. Molinas, and R. E. Stark, "Deconstructing a Plant Macromolecular Assembly: Chemical Architecture, Molecular Flexibility, and Mechanical Performance of Natural and Engineered Potato Suberins," Biomacromolecules, 15, 799-811 (2014). K. Dastmalchi, Q. Cai,K. Zhou, W. Huang,O. Serra, and R.E. Stark, "Completing the Jigsaw Puzzle of Wound-Healing Potato Cultivars: Metabolite Profiling and Antioxidant Activity," J. Agric. Food Chem., 62, 7963-7975 (2014). S. Chatterjee, R. Prados-Rosales, B. Itin, S. Tan, A. Casadevall, and R.E. Stark, "Demonstration of a Common Indole-based Aromatic Core in Natural and Synthetic Eumelanins by Solid-state NMR," Org. Biomolec. Chem., 12, 6730-6736 (2014). R.E. Stark, B. Yu, J. Zhong, B. Yan, G. Wu, and S. Tian, "Environmental NMR: High-resolution Magic-angle Spinning," in "NMR Spectroscopy: A Versatile Tool for Environmental Research," M.J. Simpson and A.J. Simpson, Ed., John Wiley and Sons Ltd., Chichester, UK, pp. 87-102 (2014).