研究领域
The research in our laboratory combines physiology, biochemistry and molecular biology to address Insect biology fundamental questions.
Currently, we are working on the nutritional regulation of juvenile hormone levels in mosquitoes
If you are interested in pursuing a Doctoral degree under my supervision please contact me
Our research program combines biochemistry, physiology and molecular biology to address fundamental questions in insect biology. We are interested in understanding mosquito’s physiological processes such as activity of the endocrine system and hormonal regulation of gene expression; my research has been funded by NIH’s RO1s for more than 15 years. Currently, the main focus of our research program is the study of the nutritional regulation of synthesis of juvenile hormone, a molecule that regulates development, reproduction and behavior in the Aedes aegypti mosquito, the vector of Dengue and Yellow fever.
近期论文
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1. Nyati, P., Rivera-Perez, C., and Noriega, FG. (2015). Negative feedbacks by isoprenoids on a mevalonate kinase expressed in the corpora allata of mosquitoes. PLoS ONE
2. Mesquita, R. D. �Noriega FG. , Nouzova, M., et al. (2015). The genome of Rhodnius prolixus, an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection. PNAS, In press.
3. Areiza, M., Nouzova, M., Rivera-Perez, C., and Noriega FG (2015). 20-hydroxyecdysone stimulation of juvenile hormone biosynthesis by the mosquito corpora allata. Insect Biochemistry and Molecular Biology. 64:100-105.
4. Hernandez-Martinez, S., Rivera-Perez, C., Nouzova M., and Noriega. FG (2015) Coordinated changes in JH biosynthesis and JH hemolymph titers in Aedes aegypti mosquitoes. J. Insect Physiology. 72: 22-27.
5. De Loof, A., Marchal, E., Rivera-Perez, C., Noriega, FG., Schoofs, L. (2015) Farnesol-like endogenous sesquiterpenoids in vertebrates: the probable but overlooked functional "inbrome" anti-aging counterpart of juvenile hormone of insects?� Frontiers in Endocrinology. doi: 10.3389/fendo.2014.00222.
6. Nouzova, M., Rivera-Perez, C., Noriega FG. (2015) Allatostatin-C reversibly blocks the transport of citrate out of the mitochondria and inhibits juvenile hormone synthesis in mosquitoes. Insect Biochemistry and Molecular Biology. 57: 20-26.
7. Wen, D., Rivera-Perez, C., Abdou, M., Jia, Q., He, Q., Zyaan, O., Bendena, WB., Tobe, SS., Noriega, FG., Palli, SR., Wang, J., Li, S. (2015) Methyl Farnesoate Plays a Dual Role in Regulating Drosophila Metamorphosis. PLoS Genet 11(3): e1005038. doi:10.1371/journal. pgen.1005038
8. Villalobos-Sambucaro MJ., Lorenzo-Figueiras, AN., Riccillo, FL., Diambra, LA., Noriega, FG., Ronderos, JR (2015). Allatotropin modulates myostimulatory and cardioacceleratory activities in Rhodnius prolixus (Stal). PLoS One. 2015 Apr 21;10(4):e0124131. doi: 10.
9. Rivera-Perez, C., Nyati, P., Noriega, FG. (2015) A corpora allata farnesyl diphosphate synthase in mosquitoes displaying a metal ion dependent substrate specificity. Insect Biochem Mol Biol. 64:44-50.
10. Noriega, FG. (2014) Juvenile hormone biosynthesis in insects: What is new, what do we know, what questions remain? ISRN. doi.org/10.1155/2014/967361
11. Rivera-Perez, C., Nouzova, M., Lamboglia, I. and Noriega FG. (2014) Metabolomics Reveals Changes in the Mevalonate and Juvenile Hormone Synthesis Pathways. Insect Biochemistry and Molecular Biology. 51: 1-9.
12. Rivera-Perez, C., Nouzova, M and Noriega, FG. (2014) New Approaches to Study Juvenile Hormone Biosynthesis in Insects. In: Short Views on Insect Biochemistry and Molecular Biology. Chapter 7. 185-216.
13. Chandrasekar, R., Brintha, PG.,.Park, EY., Pelsoi, P., Liu, F., Goldsmith, M., Ejiofor, A., Pittendrigh, BR., Han, YS., Noriega, FG., Sugumaran, M., Tyagi, BK., Zheng, Z., Zhu, GF., Patnaik, BB and Michailova, P. (2014) Introduction to Insect Molecular Biology.� In: Short Views on Insect Biochemistry and Molecular Biology. Chapter 1. 3-56.
14. Areiza, M., Nouzova, M., Rivera-Perez, C., and Noriega FG (2014). Ecdysis triggering hormone ensures proper timing of juvenile hormone biosynthesis in pharate adult mosquitoes. Insect Biochemistry and Molecular Biology.54: 98-105.
15. Clifton M.E., Correa S, Rivera-Perez, C., Nouzova, M and Noriega, FG. (2014). Male Aedes aegypti mosquitoes use JH III transferred during copulation to influence previtellogenic ovary physiology and affect the reproductive output of female mosquitoes. J Insect Physiology. Journal of Insect Physiology. 64: 40-47.
16. Perez-Hedo, M., Rivera-Perez, C. and Noriega, FG. (2014) Starvation increases insulin sensitivity and reduces juvenile hormone synthesis in mosquitoes. PLoS One 9:e86183
17. Perez M., and Noriega, FG. (2014). The sub-lethal larval metal stress response of the Dengue Fever Mosquito. Physiological Entomology. 39:111-119.
18. Alzugaray, ME., Adami, ML, Diambra L., Hernandez-Martinez, S., Damborenea, C., Noriega, FG, Ronderos, JR. (2013). Allatotropin: an ancestral myotropic neuropeptide involved in feeding. PLoS ONE 8(10): e77520. doi:10.1371/journal.pone.0077520
19. Nyati, P., Nouzova, M., Rivera-Perez, C., Clifton, ME., Mayoral, JG and Noriega, FG. (2013). Farnesyl phosphatase, a corpora allata enzyme involved in juvenile hormone synthesis in Aedes aegypti. PLoS ONE 8(8): e71967. doi:10.1371/journal.pone.0071967
20. Rivera-Perez, C., Nouzova, M., Clifton, ME., Martin Garcia, E., LeBlanc, E., and Noriega, FG. (2013) Aldehyde Dehydrogenase 3 Converts Farnesal into Farnesoic Acid in the Corpora Allata of Mosquitoes. Insect Biochem. Molec. Biol. 43:675-682.
21. Perez-Hedo, M., Rivera-Perez, C. and Noriega, FG. (2013) The Insulin/TOR signal transduction pathway is involved in the nutritional regulation of juvenile hormone synthesis in Aedes aegypti. Insect Biochem. Molec. Biol. 43:495-500.
22. Perez M., and Noriega, FG. (2013)� Aedes aegypti pharate 1st instar quiescence: A case for anticipatory reproductive plasticity. Journal of Insect Physiology. 59: 318-324.
23. Mayoral, JG., Leonard, KT., Defelipe, LA., Turjansksi, AG. and Noriega, FG. (2013). Functional Analysis of a Mosquito Short Chain Dehydrogenase Cluster. Archives of Insect Biochemistry and Physiology. 82:96-115.
24. Rivera-Perez, C., Nouzova, M and Noriega, FG. (2012) A quantitative assay for juvenile hormones and their precursors using fluorescent tags. PLoS
25. Diaz, M., Mayoral, JM., Priestap, H., Nouzova, M., Rivera-Perez, C., Noriega, FG. (2012). Characterization of an Isopentenyl Diphosphate Isomerase involved in the Juvenile Hormone pathway in Aedes aegypti. Insect Biochem. Molec. Biol. 42: 751-757.