个人简介

Ph.D., The City University of New York

研究领域

Polymer Chemistry, Molecular Biophysics, and Nanotechnology and Material Science

The current research of Dr. Shew’s lab is focused on elucidation of the self-assembly structure of aggregated macroions and the role of long-range electrostatic interactions in these self-assembly processes by using theoretical approaches. The systems under investigation include intramolecular self-assembly of a giant DNA and like-charge attraction between highly charged metal oxide ions, etc. The theoretical works of Dr. Shew’s lab have been extended to understand several existing experiments, such as the spatial configuration of a histone in a chromosome, self-assembly of highly charged metal oxide nanocluters, and high efficient gene delivery systems by use of amphoteric polyions. Meanwhile, his group has successfully developed a robust simulation algorithm that can be utilized to analyze the novel spin echo small angle neutron scattering spectra, a new neutron scattering method with great potential in characterization of the complex structure of self-assembled aggregates.

近期论文

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X. Li; C.-Y. Shew; Y. Liu; R. Pynn; E. Liu; K. W. Herwig; Smith Gregory S.; Robertson J. Lee; Chen Wei-Ren, “Prospect for characterizing interacting soft colloidal structures using spin-echo small angle neutron scattering,” J. Chem. Phys. 134, 094504 (2011) (13 pages). C.-Y. Shew and K. Yoshikawa (Book Chapter), “Elucidation of conformational behavior of a giant DNA: Single molecular observation and theoretical modeling,” in Understanding Soft Condensed Matter via Modeling and Computations, World Scientific, Singapore, Pages 207-233 (2011). X. Li, C.-Y. Shew, Y. Liu, R. Pynn, E. Liu, K. W. Herwig, J. L. Robinson and W.-R. Chen “Theoretical studies on the structure of interacting colloidal suspensions by spin-echo small angle neutron scattering.” J. Chem. Phys. 132, 174509 (2010) (14 pages). C. Yoshihara, C.-Y. Shew, T. Ito, and Y. Koyama, “Loosening of DNA/polycation Complexes by Synthetic Polyampholyte to Improve the Transcription Efficiency” Biophys. J. 98, 1257-66 (2010) C.-Y. Shew and W.-R. Chen, “A Monte Carlo algorithm for computing SESANS correlation functions in real space: Hard sphere liquids,” J. Chem. Phys. 132, 044906 (2010) (9 pages). A. Khoo*, T. Iwaki, C.-Y. Shew, and K. Yoshikawa, “Preferential Position of a Particle Bound to a Polymer: Exact Enumeration of a Self-avoiding Walk Chain Model,” J. Chem. Phys. 131, 104904 (2009) (9 pages).