个人简介

Postdoc, University Louis Pasteur (Strasbourg, France); Ph.D., Imperial College, University of London Postdoc, University Louis Pasteur (Strasbourg, France) - 1977 (Organometallic Chemistry) Ph.D., Imperial College, University of London - 1976 (Inorganic Chemistry) B.Sc., Imperial College, University of London - 1973 (Chemistry)

研究领域

Inorganic Chemistry Catalysis

Inorganic/organometallic chemistry. Sánchez-Delgado's current research interests are the discovery of novel metal-based drugs against tropical diseases (malaria, Chagas and leishmaniasis) and cancer, and the development of new catalysts derived from transition metal complexes or nano-particles for reactions related to the production of cleaner fossil fuels or improved biofuels.

近期论文

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Fang, M. and R.A. Sánchez-Delgado. "Ruthenium Nanoparticles Supported on Magnesium Oxide: A Versatile and Recyclable Dual-site Catalyst for Hydrogenation of Mono- and Poly-cyclic Arenes, N-heteroaromatics, and S-heteroaromatics." Journal of Catalysis 311: 357-68. (Books and Publications: Peer Reviewed Article) 2014 Sánchez, A., M. Fang, A. Ahmed and R.A. Sánchez-Delgado. "Hydrogenation of arenes, N-heteroaromatic compounds, and alkenes catalyzed by rhodium nanoparticles supported on magnesium oxide." Applied Catalysis A: General 477: 117-24. (Books and Publications: Peer Reviewed Article) 2014 Sánchez-Delgado, R.A. and V. Medialdea. "La química inorgánica a la búsqueda del 'Magic Bullet' en contra de enfermedades desatendidas; el caso de Latinoamérica." Las TIC en el combate de las enfermedades desatendidas: una Visión Latinoamericana. Eds. A. Ponte Sucre and L.G. Rodríguez. Fundación Telefónica, Madrid - Editorial Ariel, Barcelona, Spain. 97-120. (ISBN: 978-980-271-460-5) (Books and Publications: Chapter) 2014 Estrada, J.G. and R.A. Sánchez-Delgado. "Spectroscopic Study of the Interactions of Ruthenium-Ketoconazole Complexes of Known Antiparasitic Activity With Human Serum Albumin and Apotransferrin." Journal of the Mexican Chemical Society 57.3: 169-74. (Books and Publications: Peer Reviewed Article) 2013 Iniguez, E., A. Sánchez, M.A. Vasquez, A. Martínez, J. Olivas, A. Sattler, R.A. Sánchez-Delgado and R.A. Maldonado. "The Metal-Drug Synergy: New Ruthenium II Complexes of Ketoconazole Are Highly Active Against Leishmania major and Trypanosoma cruzi and Non-toxic to Human or Murine Normal Cells." Journal of Biological Inorganic Chemistry 18: 779-90. (Books and Publications: Peer Reviewed Article) 2013 Robles-Escajeda, E., A. Martínez, A. Varela-Ramirez, R.A. Sánchez-Delgado and R.J. Aguilera. "Analysis of the Cytotoxic Effects of Ruthenium-Ketoconazole and Ruthenium-Clotrimazole Complexes on Cancer Cells." Cell Biology and Toxicology 29: 431-43. (Books and Publications: Peer Reviewed Article) 2013 Demoro, B., C. Sarniguet, R. Sánchez-Delgado, M. Rossi, D. Liebowitz, F. Caruso, C. Olea-Azar, V. Moreno, A. Medeiros, M.A. Comini, L. Otero and D. Gambino. "New Organoruthenium Complexes With Bioactive Thiosemicarbazones as Co-ligands: Potential Anti-trypanosomal Agents." Dalton Transactions 41: 1534-43. (Books and Publications: Peer Reviewed Article) 2012 Glans, L., A. Ehnbom, C. de Kock, A. Martínez, J. Estrada, P.J. Smith, M. Haukka, R.A. Sánchez-Delgado and E. Nordlander. "Ruthenium(II) Arene Complexes With Chelating Chloroquine Analogue Ligands: Synthesis, Characterization and in Vitro Antimalarial Activity." Dalton Transactions 41: 2764-73. (Books and Publications: Peer Reviewed Article) 2012 Martínez, A., T. Carreon, E. Iniguez, A. Anzellotti, A. Sánchez, M. Tyan, A. Sattler, L. Herrera, R.A. Maldonado and R.A. Sánchez-Delgado. "Searching for New Chemotherapies for Tropical Diseases: Ruthenium-clotrimazole Complexes Display High in Vitro Activity Against Leishmania major and Trypanosoma cruzi and Low Toxicity Toward Normal Mammalian Cells." Journal of Medicinal Chemistry 55: 3867-77. (Books and Publications: Peer Reviewed Article) 2012 Rahi, R., M. Fang, A. Ahmed and R.A. Sánchez-Delgado. "Hydrogenation of Quinolines, Alkenes, and Biodiesel by Palladium Nanoparticles Supported on Magnesium Oxide." Dalton Transactions 41: 14490-97. (Books and Publications: Peer Reviewed Article) 2012 Fang, M., N. Machalaba and R A. Sánchez-Delgado. Hydrogenation of Arenes and N-heteroaromatic Compounds Over Ruthenium Nanoparticles on poly(4-vinylpyridine): A Versatile Catalyst Operating by a Substrate-dependent Dual Site Mechanism. Dalton Transactions 40: 10621-32. (Books and Publications: Peer Reviewed Article) 2011 Martínez, A., J. Suárez, T. Shand, R.S. Magliozzo and R.A. Sánchez-Delgado. "Interactions of Arene-Ru(II)-chloroquine Complexes of Known Antimalarial and Antitumor Activity With Human Serum Albumin (HSA) and Transferrin." Journal of Inorganic Biochemistry 105: 39-45. (Books and Publications: Peer Reviewed Article) 2011 Navarro, M., W. Castro, A. Martínez and R.A. Sánchez-Delgado. "The Mechanism of Antimalarial Action of [Au(CQ)(PPh3)]PF6: Structural Effects and Increased Drug Lipophilicity Enhance Heme Aggregation Inhibition at Llipid/water Interfaces." Journal of Inorganic Biochemistry 105: 276-82. (Books and Publications: Peer Reviewed Article) 2011 Navarro, M., W. Castro, A.R., Higuera-Padilla, A. Sierraalta, M. J. Abad, P. Taylor and R.A. Sánchez-Delgado. "Synthesis, Characterization and Biological Activity of Trans-platinum (II) Complexes With Chloroquine." Journal of Inorganic Biochemistry 105: 1684-91. (Books and Publications: Peer Reviewed Article) 2011 Martínez, A., Ch. S.K. Rajapakse, A. Varela-Ramírez, C. Lema, R.J. Aguilera and R.A. Sánchez-Delgado. "Arene-Ru(II)-Chloroquine Complexes Interact With DNA, Induce Apoptosis on Human Lymphoid Cell Lines and Display Low Toxicity to Normal Mammalian Cells." Journal of Inorganic Biochemistry 104: 967-77. (Books and Publications: Peer Reviewed Article) 2010 Jimenez, Sonia, Jose A. Lopez, Miguel A. Ciriano, Cristina Tejel, Alberto Martinez and Roberto A. Sánchez-Delgado, "Selective Hydrogenation of Cinnamaldehyde and Other alfa,beta-Unsaturated Substrates Catalyzed by Rhodium and Ruthenium Complexes." Organometallics 28: 3193-202. (Books and Publications: Peer Reviewed Article) 2009 Landaeta, V.R., F. Lopez-Linares, R. Sánchez-Delgado, C. Bianchini, F. Zanobini and M. Peruzzini. "Synthesis and Characterization of New Rhodium and Iridium Complexes With Trianisylphosphine and Evaluation of Their Catalytic Behavior in the Homogeneous Hydrogenation of Cinnamaldehyde." Journal of Molecular Catalysis A: Chemistry 310: 1-10. (Featured as Editor's Choice paper). (Books and Publications: Peer Reviewed Article) 2009 Martínez, A., Ch. S.K. Rajapakse, D. Jalloh, C. Dautriche and R.A. Sánchez-Delgado. "The Antimalarial Activity of Ru-chloroquine Complexes Against Resistant Plasmodium falciparum Is Related to Lipophilicity, Basicity and Heme Aggregation Inhibition Ability Near Water/ n -octanol Interfaces." Journal of Biological Inorganic Chemistry 14: 863-71. (Books and Publications: Peer Reviewed Article) 2009 Rajapakse, C.S.K., A. Martinez, B. Naoulou, A. A. Jarzecki, L. Suarez, C. Deregnaucourt, V. Sinou, J. Schrevel, E. Musi, G. Ambrosini, G.K. Schwartz and R. A. Sánchez-Delgado. "Synthesis, Characterization and in vitro Antimalarial and Antitumor Activity of New Ruthenium(II) Complexes of Chloroquine." Inorganic Chemistry 48: 1122-31. (Books and Publications: Peer Reviewed Article) 2009 Martinez, A., Ch. S.K. Rajapakse, B. Naoulou, Y. Kopkalli, L. Davenport and R.A. Sanchez-Delgado. "The Mechanism of Antimalarial Action of the Ruthenium(II)-chloroquine Complex [RuCl2(CQ)]2." Journal of Biological Inorganic Chemistry 13: 703-12. DOI 10.1007/s00775-008-0356-9. (Books and Publications: Peer Reviewed Article) 2008