West, Lyndon - Florida Atlantic University - Department of Chemistry and Biochemistry

研究领域

Discovery of pharmacologically-active metabolites from marine invertebrates, anti-cancer and anti-microbial agents, use of stem cells in developing new drugs for cardiovascular and neurodegenerative diseases and development of novel approaches for the separation and characterization of marine natural products to accelerate the discovery of drug leads

近期论文

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West, L. M.; Faulkner D. J. Acanthosulfate, a Sulfated Hydroxyhydroquinone Seserterpene form the Sponge Acanthodendrilla. J. Nat. Prod. 2008, 71, 269 -271. West, L. M.; Faulkner D. J. Hexaprenoid hydroquinones from the Sponge Haliclona (aka Adocia) sp. J. Nat. Prod. 2006, 69, 1001-1004. Page M. J.; West, L. M.; Northcote P. T.; Kelly-Shanks M. Spatial and Temporal Variability of Cytotoxic Metabolites in Populations of the New Zealand Sponge Mycale hentscheli (Poecilosclerida: Mycalidae) J. Chem Ecology, Chem. Ecology, 2005, 31, 1161-1174. Fenical W.; Jensen P. R.; Kauffman C.; Mayhead S. L.; Faulkner D. J.; Sincich, C.; Rama Rao M.; Kantorowski E. J.; West L. M.; Strangman W. K.; Shimizu Y.; Li B.; Thammana S.; Drainville K.; Davies-Coleman M. T.; Kramer R. A.; Fairchild C. R.; Rose W. C.; Wild R. C.; Vite C. D.; Peterson R. W. New Anticancer Drugs from Cultured and Collected Marine Organisms. Pharm. Biology 2003, 41, 6-14. Meragelman K. M.; West, L. M.; Northcote P. T.; Pannell, L. K.; McKee T. C.; Boyd, M. R. Unusual Sulfamate Indoles and a Novel Indolo[3,2- a] carbazole from Ancorina sp. J. Org. Chem. 2002, 67, 6671-6677. Hood K. A.; West L. M.; Rouw�, B.; Northcote P. T.; Berridge M. V.; Miller J. H. Peloruside A, a New Class of Anti-Mitotic Agent with Paclitaxel-Like Microtubule-Stabilizing Activity. Cancer Res. 2002, 62, 3356-3360. Hood K. A.; B�ckstr�m, B. T, West L. M.; Northcote, P. T.; Berridge, M. V.; Miller, J. H. The Novel Cytotoxic Sponge Metabolite Peloruside A, Structurally Similar to Bryostatin-1, has Unique Bioactivity Independent of Protein Kinase C. Anti-Cancer Drug Design, 2001, 16, 155-166. Hood K. A.; West L. M.; Northcote P. T. Berridge M. V.; Miller J. H. Induction of Apoptosis by the Marine Sponge (Mycale) Metabolites, Mycalamide A and Pateamine. Apoptosis 2001, 6, 207-219. West L.M.; Northcote P. T.; Hood K. A.; Miller J. H.; Page, M. J. Mycalamide D, a new Cytotoxic Amide from the New Zealand Marine Sponge Mycale Species. J. Nat. Prod., 2000, 63, 707-709. West L. M.; Northcote, P. T.; Battershill C. N. Peloruside A: A Potent Cytotoxic Macrolide Isolated from the New Zealand Marine Sponge Mycale sp. J. Org. Chem. 2000, 65, 445-449. West L. M.; Northcote, P. T.; Battershill C. N. Two New Clerodane diterpenes from the New Zealand Marine Sponge Raspailia sp. Aust. J. Chem. 1998, 51, 1097-1101.