Rezler, Evonne M - Florida Atlantic University - Department of Chemistry and Biochemistry

研究领域

My main research interests are in chemical education, involving the adaptation and incorporation of novel and green chemistry as well as spectroscopy-based research into the undergraduate chemistry curriculum. The goal being to enhance active student participation and engagement in their learning process. I am also working on strategies to assess the outcomes for student learning as a result of the implementation of these innovations. My biomolecular research interests focus on: 1. the development and application of spectroscopic techniques to investigate mechanisms of delivery and up-take of cell penetrating peptides (CPPs) and other potential drug carriers into live cells; and 2. the study of the roles of secondary DNA structures (such as G-quadruplexes) in mediating cancer onset (and aging) in oncogene promoter regions and telomeres. The biological roles of secondary structures of RNA based molecules (e.g. siRNA and ribozymes) in the human body are also of great interest and very amenable to study using various spectroscopic techniques.

近期论文

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J. Ye, S.A. Fox, M. Cudic, E.M. Rezler, J.L. Lauer-Fields, G.B. Fields, A.C. Terentis “Determination of Penetratin Secondary Structure in Live Cells with Raman Microscopy” J. Am. Chem. Soc. 132, 980–988, (2010). D.R. Khan, E.M. Rezler, J. Lauer-Fields, G.B. Fields, "Effects of Drug Hydrophobicity on Liposomal Stability" Chem. Biol. Drug Des. 71, 3-7 (2008). Y. Qin, E.M. Rezler, V. Gokhale, D. Sun, L.H. Hurley, "Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4" Nucleic Acids Res. 35(22), 7698-7713 (2007). E.M. Rezler, D.R. Khan, J. Lauer-Fields, M. Cudic, D. Baronas-Lowell, G.B. Fields, “Targeted drug delivery utilizing protein-like molecular architecture,” J. Am. Chem. Soc. 129, 4961- 4972 (2007). E.M. Rezler, D.R. Khan, R. Tu, M. Tirrell, G.B. Fields, “Peptide-Mediated Targeting of Liposomes to Tumor Cells”, Methods Mol. Biol. 386, 269-298 (2007).