Cudic, Predrag - Florida Atlantic University - Department of Chemistry and Biochemistry

研究领域

My research interests are in the broadly defined fields of chemical biology and medicinal chemistry. My research team uses rational synthetic and combinatorial chemistry approaches to synthesize and elucidate structure-activity relationship of novel cyclic peptides as biological probes or lead compounds for drug discovery. Our research has implications for treatment of multi-drug resistant bacterial infections and treatment of central nervous system diseases.

近期论文

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Bionda N, Fleeman RM, de la Fuente-Núñez C, Rodriguez MC, Reffuveille F, Shaw LN, Pastar I, Davis SC, Hancock RE, Cudic P. Identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities. Eur. J. Med. Chem. 108 (2016) 3543-63. PubMed PMID: 26703794. Cudic P, Joshi N, Sagher D, Williams BT, Stawikowski MJ, Weissbach H. Identification of activators of methionine sulfoxide reductases A and B. Biochem. Biophys. Res. Commun. 469 (2016) 863-786. PubMed PMID: 26718410. Jakas A, Perc M, Suc J, Rodriguez MC, Cudic M, Cudic P. Synthesis of anthrose lipidic derivative as mimic of B. anthracis BclA glycoprotein for use in ELISA-like binding assays. J. Carbohydr. Chem. 35 (2016) 69-85. http://dx.doi.org/10.1080/07328303.2016.1139124 Bionda N, Pastar I, Davis SC, Cudic P. In vitro and in vivo activities of novel cyclic lipopeptides against staphylococcal biofilms. Protein Pept. Lett. 21 (2014) 52-56. PubMed PMID: 24164269. Bionda N, Stawikowski M, Stawikowska R, Cudic M, López-Vallejo F, Treitl D, Medina-Franco J, Cudic P. Effects of cyclic lipodepsipeptide structural modulation on stability, antibacterial activity, and human cell toxicity. ChemMedChem. 7 (2012) 871-882. PubMed PMID: 22392790.